Abstract
A study has been made of the effects of chlorpromazine and chlorpromazine sulfoxide in normal and tourniquet-shocked mice.
In normal mice chlorpromazine (20 mgm./kgm.) produced a) marked decrease in body temperature, and b) an increased bleeding volume accompanied by decreased hematocrit and plasma protein levels (indicating a movement of extravascular fluid into the circulation). Chlorpromazine augmented and prolonged the hemodynamic effects of intravenously administered serum and saline. Pretreatment with chlorpromazine markedly decreased the swelling of the injured area of tourniquet-shocked mice and greatly improved the diminished bleeding volume which follows tourniquet trauma.
Chiorpromazine sulfoxide (25 mgm./kgm.) produced no demonstrable effect on body temperature, on bleeding volume and hematocrit and plasma protein levels of normal mice, or on the swelling of the injured area of shocked mice.
Although these drugs are effective only when given prophylactically, their therapeutic action was not attributable to an effect localized exclusively within the injured area.
The relation of the hemodynamic and anti-swelling effects to therapeutic effect are discussed.
Footnotes
- Received January 9, 2012.
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