Abstract
The rat and the cat, like the mouse, excrete C14 in the urine in large part as what may be unchanged atropine (with an Rf of 0.75 to 0.84). In one rat urine collected 6.5 hr. after atropine injection, about 1.4 per cent of the C14 in the urine was in the form of a tropic-acid-like compound (Rf 0.92). The substances responsible for the other chromatographically separable loci of C14 have not been identified even tentatively in this work. The most important of these loci of C14 in rat urine have Rf's of about 0.06, 0.19, 0.61 and 0.70.
The guinea pig excretes the C14 from labeled atropine primarily as "tropic acid," with "unaltered atropine" as a less important urinary excretion product.
In the rat, urinary excretions of C14 after i.v., i.m. or s.c. injections of labeled atropine were approximately the same. Urinary excretion of C14 after oral or i.p. administration of labeled atropine was about 70 per cent of the mean excretion with the first 3 routes of administration.
The liver, the kidney, the lung and the pancreas are the most important nonhollow organs in taking up the labeled material initially. The hollow organs which show the highest initial uptake of the C14 label are the duodenum and jejunum. There is a progressive movement of label down the intestinal lumen. The liver is thought to excrete products of atropine metabolism via the bile.
In the rat and the cat, unlike the mouse and the guinea pig, excretion of C14 in the feces is almost equal in importance to urinary excretion.
Footnotes
- Received July 19, 1957.
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