Abstract
Imidazoleacrylcholine (ImAcrCh) and imidazolepropionylcholine (ImPrCh) potentiated the effects of histamine on the smooth muscle of guinea pig ileum, lung and trachea.
The potentiation of histamine did not appear to be related to kmown pharmacologic effects of these choline esters. The imidazoleacylcholine esters were unable to potentiate serotonin, β-2-pyridylethylamine, or acetylcholine. They did not inhibit monamine oxidase, spermine oxidase, or a histamine-metabolizing enzyme obtained from mouse liver. Blockade of the potentiation was best seen with the use of an antihistamine.
It was concluded that ImAcrCh and ImPrCh potentiate histamine by inhibition of diamine oxidase, an enzyme that metabolizes histamine.
Footnotes
- Received June 5, 1957.
JPET articles become freely available 12 months after publication, and remain freely available for 5 years.Non-open access articles that fall outside this five year window are available only to institutional subscribers and current ASPET members, or through the article purchase feature at the bottom of the page.
|
Log in using your username and password
Purchase access
You may purchase access to this article. This will require you to create an account if you don't already have one.
In this issue
Jump to section
Related Articles
Cited By...
More in this TOC Section
Similar Articles
Advertisement