Abstract
Hydroxydione, a new intravenous anesthetic, in four times the dose of thio-pental was much less depressant to the cardiovascular system in anesthetized cats and dogs, and to the heart-lung preparation of the dog. It produced insignificant effects on the cardiac rate and rhythm and the electrocardiographic pattern.
In the normal and hypodynamic amphibian heart hydroxydione in low concentration usually exerted a negative chronotropic, positive inotropic and cardiotonic effects. In higher concentrations it depressed the heart and delayed A-V conduction.
Hydroxydione in four times the dose of thiopental sodium was much less depressant to the respiratory system. It did not produce apnea.
Hydroxydione produced pronounced relaxant and anti-spasmodic effects on ileal and tracheal smooth muscle.
Footnotes
- Received April 22, 1957.
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