Abstract

Livers from vitamin K-deficient chicks showed increased DPNH-oxidase activity with no change in either DPNH-cytochrome c reductase or diaphorase. Dicumarol-treatment had no effect on DPNH-oxidase, aerobic or anaerobic glycolysis, aspartic-glutamic transaminase, ATP-ase, AMP-ase, G-6-P-ase, HDP-ase, xanthine oxidase, pyruvate oxidation, or oxidative phosphorylation. Oxidative phosphorylation was depressed, however, when Dicumarol was added in vitro to normal liver mitochondria in concentrations that approximate those which obtain in vivo.