Abstract
1. The acetylcholine (ACh) blocking effect of various ganglionic and neuromuscular blocking agents was determined on the isolated heart of the mollusc, Venus mercenaria.
2. d-Tubocurarine, decamethonium and dihydro-beta-erythroidine showed no acetylcholine (ACh) blocking activity at concentrations as great as 1:10,000. Sparteine has little activity, even at high concentrations (1:10,000).
3. Tetraethylammonium bromide (TEA), and various benzoquinone derivatives reduced and, at higher concentrations, blocked the inhibitory effect of acetylcholine (ACh) on the Venus heart. WIN 2747 [2,5-bis(diethylamino-propylamino)-benzoquinone benzochloride], the most potent compound tested, was about 1000 times more active than tetraethylammonium bromide (TEA).
4. No correlation was found between acetylcholine blocking activity on the Venus heart and ganglionic blocking, curarimimetic or anticholinesterase activities.
Footnotes
- Received February 19, 1952.
JPET articles become freely available 12 months after publication, and remain freely available for 5 years.Non-open access articles that fall outside this five year window are available only to institutional subscribers and current ASPET members, or through the article purchase feature at the bottom of the page.
|
