Abstract
The effect of α-β and β-γ unsaturated angelica lactones upon the cardiac action of digitoxin was studied.
When digitoxin is infused simultaneously with β-γ unsaturated angelica lactone, there appears to be no statistically significant change in the toxicity of the glycoside. The rapid superimposed intravenous injection (200 mgm./kgm.) of this lactone during digitoxin infusion in cats induces a premature ventricular fibrillation.
α-β Unsaturated angelica lactone does not influence the lethal dose of digitoxin when infused simultaneously with the glycoside. However if 200 mgm./kgm. of the lactone is rapidly injected intravenously it abolishes the digitalis irregularities for a brief period.
The α-β lactone also eliminates cardiac irregularities due to barium chloride infusion. Therefore the antagonism of the lactone to digitoxin cannot be explained by the theory of competition of chemically related structures for the same receptors.
Footnotes
- Received February 12, 1951.
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