Abstract
1. Certain pharmacological properties have been presented of m-tolyloxy-acetamidine hydrochloride, a substance with marked positive inotropic and chronotropic effects upon the heart-lung preparation and upon the isolated, perfused hearts of some but not all of the five species studied.
2. The mechanism of action is presumably histaminic, since it could be antagonized by the same doses of tripelennamine required to antagonize the effects of histamine and was not influenced by doses of procaine hydrochloride and atropine sulfate comparable in activity to the local anesthetic and parasympatholytic actions, respectively, of tripelennamine.
3. The results would appear not to support the concept of competitive inhibition between histamine and antihistaminics for the same "receptor substance".
Footnotes
- Received November 30, 1950.
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