Abstract

1. The most accurate dose-action curve for the pressor action of epinephrine is Rosenblueth's hyperbola: y = x/(a + bx)0 ≤ x ≤ 100.

2. A similar hyperbola most accurately relates maximum blood pressure attained with the dose of epinephrine: Y = x/(A + Bx) 0 ≤ x ≤ 100.

3. Of the two equations, the one for the pressor action is the more accurate.

4. Hyperbolic equations yield the only curves which will fit the data accurately over the entire dosage range used.

5. The official assay can be extended in range by use of a correct dose-action curve for the pressor action of epinephrine.