Abstract
1. Diuretic doses of 15 mg./kg. of formoguanamine were fed to a group of six dogs 72 times each, and 24 doses of 20 mg./kg. to a group of six rabbits without producing toxic effects.
2. In agreement with previous assays in rats and dogs, formoguanamine produces a significant diuresis and chloruresis in normal fasting persons in doses between 4 and 9 mg./kg.
3. Under standard conditions of test in human beings–administration of 350 ml. of 0.85% NaCl solution together with the diuretic–8 to 9 mg./kg. of formoguanamine removed 90 to 100 per cent of the introduced fluid in four hours.
4. Doses above 9 mg./kg. may produce thirst, prolonged diuresis and feeling of discomfort in the lumbar region.
5. Formoguanamine proved to be more consistent in diuretic activity than the xanthine diuretics under comparable conditions.
Footnotes
- Received August 6, 1947.
- 1948 by The American Society for Pharmacology and Experimental Therapeutics
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