Abstract
The mitochondrial fraction of brain, which contains cerebroside sulfate (CS), causes potassium to become soluble in a lipid solvent. The mitochondrial fraction of liver, which does not contain CS, has no such effect. In brain, CS is found in the fraction of mitochondnia that remains in solution after centnifugation of the mitochondrial membrane.
Purified CS forms lipid soluble complexes with norepinephnine, histamine, acetylcholine, and 5-hydroxytryptamine. Cerebroside sulfate caused a contraction of guinea pig ileum which was prevented by atropine. Several other lipid extracts of brain had the same action, and, in addition, one of them potentiated the action of histamine on guinea pig ileum.
Footnotes
- Received June 3, 1960.
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