Abstract

Pendiomide in doses of 6 to 12 mgm./kgm. produces adequate ganglionic blockade to block the transmission of electrical stimuli along the vagus nerve. In this dosage range in dogs, Pendiomide is a relatively effective hypotensive agent. When Pendiomide is given in this concentration, renal vascular resistance decreases and renal blood flow, glomerular filtration rate, and the excretion of water and electrolytes are not altered appreciably.

If glomerular filtration rate is depressed following ganglionic blockade and blood pressure reduction, norepinephrine will increase the blood pressure and return glomerular filtration rate towards the control values. This is usually associated with an increase in sodium and water excretion.