Journal of Pharmacology and Experimental Therapeutics: 349 (2)

May 01, 2014; Volume 349,Issue 2

Highlighted Papers

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Tonic Inhibition of G Protein–Coupled Receptor Kinase 2 of Endothelial Protein Kinase B/Endothelial Nitric-Oxide Synthase Signaling
Journal of Pharmacology and Experimental Therapeutics May 2014, 349 (2) 175; DOI: https://doi.org/10.1124/jpet.114.0514HI
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Clinical and Preclinical Characterization of a Histamine H₄ Antagonist
Journal of Pharmacology and Experimental Therapeutics May 2014, 349 (2) 175; DOI: https://doi.org/10.1124/jpet.114.0514HIa
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Tolvaptan Delays the Onset of End-Stage Renal Disease in Polycystic Kidney Disease
Journal of Pharmacology and Experimental Therapeutics May 2014, 349 (2) 175; DOI: https://doi.org/10.1124/jpet.114.0514HIb
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Intermittent Cocaine Administration Produces Sensitization of Stimulants at the Dopamine Transporter
Journal of Pharmacology and Experimental Therapeutics May 2014, 349 (2) 175; DOI: https://doi.org/10.1124/jpet.114.0514HIc

Behavioral Pharmacology

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Activation of α4β2*/α6β2* Nicotinic Receptors Alleviates Anxiety during Nicotine Withdrawal Without Upregulating Nicotinic Receptors
Nicole L. Yohn, Jill R. Turner and Julie A. Blendy

Journal of Pharmacology and Experimental Therapeutics May 2014, 349 (2) 348-354; DOI: https://doi.org/10.1124/jpet.113.211706

Cardiovascular

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Tonic Inhibition by G Protein–Coupled Receptor Kinase 2 of Akt/Endothelial Nitric-Oxide Synthase Signaling in Human Vascular Endothelial Cells under Conditions of Hyperglycemia with High Insulin Levels
Kumiko Taguchi, Kimimasa Sakata, Wakana Ohashi, Takahiro Imaizumi, Joji Imura and Yuichi Hattori

Journal of Pharmacology and Experimental Therapeutics May 2014, 349 (2) 199-208; DOI: https://doi.org/10.1124/jpet.113.211854

Cellular and Molecular

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Silibinin Induces Cell Death through Reactive Oxygen Species–Dependent Downregulation of Notch-1/ERK/Akt Signaling in Human Breast Cancer Cells
Thae Hyun Kim, Jae Suk Woo, Yong Keun Kim and Ki Hyung Kim

Journal of Pharmacology and Experimental Therapeutics May 2014, 349 (2) 268-278; DOI: https://doi.org/10.1124/jpet.113.207563

Drug Discovery and Translational Medicine

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Clinical and Preclinical Characterization of the Histamine H₄ Receptor Antagonist JNJ-39758979
Robin L. Thurmond, Bin Chen, Paul J. Dunford, Andrew J. Greenspan, Lars Karlsson, David La, Peter Ward and Xie L. Xu

Journal of Pharmacology and Experimental Therapeutics May 2014, 349 (2) 176-184; DOI: https://doi.org/10.1124/jpet.113.211714
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Novel Curcumin Derivative CNB-001 Mitigates Obesity-Associated Insulin Resistance
Evgeniy Panzhinskiy, Yinan Hua, Paul A. Lapchak, Elena Topchiy, Teresa E. Lehmann, Jun Ren and Sreejayan Nair

Journal of Pharmacology and Experimental Therapeutics May 2014, 349 (2) 248-257; DOI: https://doi.org/10.1124/jpet.113.208728
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2-Isoxazol-3-Phenyltropane Derivatives of Cocaine: Molecular and Atypical System Effects at the Dopamine Transporter
Takato Hiranita, Derek S. Wilkinson, Weimin C. Hong, Mu-Fa Zou, Theresa A. Kopajtic, Paul L. Soto, Carl R. Lupica, Amy H. Newman and Jonathan L. Katz

Journal of Pharmacology and Experimental Therapeutics May 2014, 349 (2) 297-309; DOI: https://doi.org/10.1124/jpet.113.212738
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A Novel Aminotetralin-Type Serotonin (5-HT) _2C Receptor-Specific Agonist and 5-HT_2A Competitive Antagonist/5-HT_2B Inverse Agonist with Preclinical Efficacy for Psychoses
Clinton E. Canal, Drake Morgan, Daniel Felsing, Krishnakanth Kondabolu, Neil E. Rowland, Kimberly L. Robertson, Rajeev Sakhuja and Raymond G. Booth

Journal of Pharmacology and Experimental Therapeutics May 2014, 349 (2) 310-318; DOI: https://doi.org/10.1124/jpet.113.212373
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Discovery of Novel Second Mitochondria-Derived Activator of Caspase Mimetics as Selective Inhibitor of Apoptosis Protein Inhibitors
Jin Wang and Wei Li

Journal of Pharmacology and Experimental Therapeutics May 2014, 349 (2) 319-329; DOI: https://doi.org/10.1124/jpet.113.212019
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Follistatin: A Novel Therapeutic for the Improvement of Muscle Regeneration
Benjamin C. Yaden, Johnny E. Croy, Yan Wang, Jonathan M. Wilson, Amita Datta-Mannan, Pamela Shetler, Andrea Milner, Henry U. Bryant, Jessica Andrews, Guoli Dai and Venkatesh Krishnan

Journal of Pharmacology and Experimental Therapeutics May 2014, 349 (2) 355-371; DOI: https://doi.org/10.1124/jpet.113.211169

Gastrointestinal, Hepatic, Pulmonary, and Renal

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Tolvaptan Delays the Onset of End-Stage Renal Disease in a Polycystic Kidney Disease Model by Suppressing Increases in Kidney Volume and Renal Injury
Miki Aihara, Hiroyuki Fujiki, Hiroshi Mizuguchi, Katsuji Hattori, Koji Ohmoto, Makoto Ishikawa, Keisuke Nagano and Yoshitaka Yamamura

Journal of Pharmacology and Experimental Therapeutics May 2014, 349 (2) 258-267; DOI: https://doi.org/10.1124/jpet.114.213256
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Generation and Activity of a Humanized Monoclonal Antibody That Selectively Neutralizes the Epidermal Growth Factor Receptor Ligands Transforming Growth Factor-α and Epiregulin
Catherine B. Beidler, Ramona J. Petrovan, Elaine M. Conner, Jeffrey S. Boyles, Derek D. Yang, Shannon M. Harlan, Shaoyou Chu, Bernice Ellis, Amita Datta-Mannan, Robert L. Johnson, Anja Stauber, Derrick R. Witcher, Matthew D. Breyer and Josef G. Heuer

Journal of Pharmacology and Experimental Therapeutics May 2014, 349 (2) 330-343; DOI: https://doi.org/10.1124/jpet.113.210765

Inflammation, Immunopharmacology, and Asthma

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Antifibrotic and Anti-inflammatory Activity of the Tyrosine Kinase Inhibitor Nintedanib in Experimental Models of Lung Fibrosis
Lutz Wollin, Isabelle Maillet, Valérie Quesniaux, Alexander Holweg and Bernhard Ryffel

Journal of Pharmacology and Experimental Therapeutics May 2014, 349 (2) 209-220; DOI: https://doi.org/10.1124/jpet.113.208223
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Arginase Inhibition Prevents Inflammation and Remodeling in a Guinea Pig Model of Chronic Obstructive Pulmonary Disease
T. Pera, A. B. Zuidhof, M. Smit, M. H. Menzen, T. Klein, G. Flik, J. Zaagsma, H. Meurs and H. Maarsingh

Journal of Pharmacology and Experimental Therapeutics May 2014, 349 (2) 229-238; DOI: https://doi.org/10.1124/jpet.113.210138
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Pseudomonas aeruginosa Mannose-Sensitive Hemagglutinin Promotes T-Cell Response via Toll-Like Receptor 4–Mediated Dendritic Cells to Slow Tumor Progression in Mice
Min Zhang, Feifei Luo, Yufei Zhang, Luman Wang, Wei Lin, Mengxuan Yang, Dali Hu, Xiaofeng Wu and Yiwei Chu

Journal of Pharmacology and Experimental Therapeutics May 2014, 349 (2) 279-287; DOI: https://doi.org/10.1124/jpet.113.212316

Metabolism, Transport, and Pharmacogenomics

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A Targeted Proteomics Approach for Profiling Murine Cytochrome P450 Expression
Elisabeth M. Hersman and Namandjé N. Bumpus

Journal of Pharmacology and Experimental Therapeutics May 2014, 349 (2) 221-228; DOI: https://doi.org/10.1124/jpet.113.212456

Neuropharmacology

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Intermittent Cocaine Self-Administration Produces Sensitization of Stimulant Effects at the Dopamine Transporter
Erin S. Calipari, Mark J. Ferris, Cody A. Siciliano, Benjamin A. Zimmer and Sara R. Jones

Journal of Pharmacology and Experimental Therapeutics May 2014, 349 (2) 192-198; DOI: https://doi.org/10.1124/jpet.114.212993
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Casein Kinase II Inhibition Reverses Pain Hypersensitivity and Potentiated Spinal N-Methyl-d-aspartate Receptor Activity Caused by Calcineurin Inhibitor
Yi-Min Hu, Shao-Rui Chen, Hong Chen and Hui-Lin Pan

Journal of Pharmacology and Experimental Therapeutics May 2014, 349 (2) 239-247; DOI: https://doi.org/10.1124/jpet.113.212563
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5-Hydroxytryptamine–Mediated Neurotransmission Modulates Spontaneous and Vagal-Evoked Glutamate Release in the Nucleus of the Solitary Tract Effect of Uptake Blockade
Patrick S. Hosford, Steve W. Mifflin and Andrew G. Ramage

Journal of Pharmacology and Experimental Therapeutics May 2014, 349 (2) 288-296; DOI: https://doi.org/10.1124/jpet.113.211334

Toxicology

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Trovafloxacin Potentiation of Lipopolysaccharide-Induced Tumor Necrosis Factor Release from RAW 264.7 Cells Requires Extracellular Signal-Regulated Kinase and c-Jun N-Terminal Kinase
Kyle L. Poulsen, Ryan P. Albee, Patricia E. Ganey and Robert A. Roth

Journal of Pharmacology and Experimental Therapeutics May 2014, 349 (2) 185-191; DOI: https://doi.org/10.1124/jpet.113.211276

Notices of Retraction

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Re: Yamashita J, Itoh M, Kuro T, Kobayashi Y, Ogata M, Takaoka M, and Matsumura Y (2001) Pre- or Post-Ischemic Treatment with a Novel Na⁺/Ca²⁺ Exchange Inhibitor, KB-R7943, Shows Renal Protective Effects in Rats with Ischemic Acute Renal Failure. J Pharmacol Exp Ther 296:412–419
Journal of Pharmacology and Experimental Therapeutics May 2014, 349 (2) 344; DOI: https://doi.org/10.1124/jpet.114.05er14
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Re: Nakajima A, Ueda K, Takaoka M, Yoshimi Y, and Matsumura Y (2006) Opposite Effects of Pre- and Postischemic Treatments with Nitric Oxide Donor on Ischemia/Reperfusion-Induced Renal Injury. J Pharmacol Exp Ther 316:1038–1046; doi:10.1124/jpet.105.092049
Journal of Pharmacology and Experimental Therapeutics May 2014, 349 (2) 345; DOI: https://doi.org/10.1124/jpet.114.05er14a
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Re: Ueda K, Tsuju F, Hirata T, Ueda K, Murai M, Aono H, Takaoka M, and Matsumura Y (2009) Preventive Effect of SA13353 [1-[2-(1-Adamantyl)ethyl]-1-pentyl-3-[3-(4-pyridyl)propyl]urea], a Novel Transient Receptor Potential Vanilloid 1 Agonist, on Ischemia/Reperfusion-Induced Renal Injury in Rats. J Pharmacol Exp Ther 329:202–209; doi:10.1124/jpet.108.146241
Journal of Pharmacology and Experimental Therapeutics May 2014, 349 (2) 346; DOI: https://doi.org/10.1124/jpet.114.05er14b
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Re: Kobuchi S, Tanaka R, Shintani T, Suzuki R, Tsutsui H, Ohkita M, Ayajiki K, and Matsumura Y (2011) Mechanisms Underlying the Renoprotective Effect of GABA against Ischemia/Reperfusion-Induced Renal Injury in Rats. J Pharmacol Exp Ther 338:767–774; doi:10.1124/jpet.111.180174
Journal of Pharmacology and Experimental Therapeutics May 2014, 349 (2) 347; DOI: https://doi.org/10.1124/jpet.114.05er14c

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Table of Contents

Highlighted Papers

Behavioral Pharmacology

Cardiovascular

Cellular and Molecular

Drug Discovery and Translational Medicine

Gastrointestinal, Hepatic, Pulmonary, and Renal

Inflammation, Immunopharmacology, and Asthma

Metabolism, Transport, and Pharmacogenomics

Neuropharmacology

Toxicology

Notices of Retraction

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