Table of Contents

Drug Discovery and Translational Medicine

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  Effects of Tegoprazan, a Novel Potassium-Competitive Acid Blocker, on Rat Models of Gastric Acid–Related Disease

  Dong Kyu Kim, Keun-Ho Lee, Sung-jun Kim, Soo-Jin Kim, Song Jin Lee, Chi Hye Park, Bong-Tae Kim, Geun-Seog Song, Byoung-Seok Moon and Shin-Young Ryu

  Journal of Pharmacology and Experimental Therapeutics June 2019, 369 (3) 318-327; DOI: https://doi.org/10.1124/jpet.118.254904
• Open Access

  Relationship between Pharmacokinetics and Pharmacodynamic Responses in Healthy Smokers Informs a Once-Daily Dosing Regimen for Nemiralisib

  M. Begg, R. Wilson, J.N. Hamblin, M. Montembault, J. Green, A. Deans, A. Amour, S. Worsley, K. Fantom, Y. Cui, G. Dear, S. Ahmad, A. Kielkowska, J. Clark, M. Boyce, A. Cahn and E.M. Hessel

  Journal of Pharmacology and Experimental Therapeutics June 2019, 369 (3) 337-344; DOI: https://doi.org/10.1124/jpet.118.255109
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  Modulation of TARP γ8–Containing AMPA Receptors as a Novel Therapeutic Approach for Chronic Pain

  Kelly L. Knopp, Rosa Maria A. Simmons, Wenhong Guo, Benjamin L. Adams, Kevin M. Gardinier, Douglas L. Gernert, Paul L. Ornstein, Warren Porter, Jon Reel, Chunjin Ding, He Wang, Yuewei Qian, Kevin D. Burris, Anne Need, Vanessa Barth, Steven Swanson, John Catlow, Jeffrey M. Witkin, Ruud Zwart, Emanuele Sher, Kar-Chan Choong, Theron M. Wall, Douglas Schober, Christian C. Felder, Akihiko S. Kato, David S. Bredt and Eric S. Nisenbaum

  Journal of Pharmacology and Experimental Therapeutics June 2019, 369 (3) 345-363; DOI: https://doi.org/10.1124/jpet.118.250126
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  Beneficial Effects of Trehalose on Striatal Dopaminergic Deficits in Rodent and Primate Models of Synucleinopathy in Parkinson’s Disease

  Patrick A. Howson, Tom H. Johnston, Paula Ravenscroft, Michael P. Hill, Jin Su, Jonathan M. Brotchie and James B. Koprich

  Journal of Pharmacology and Experimental Therapeutics June 2019, 369 (3) 364-374; DOI: https://doi.org/10.1124/jpet.118.255695
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  Exposure-Effect Relationships in Established Rat Adjuvant-Induced and Collagen-Induced Arthritis: A Translational Pharmacokinetic-Pharmacodynamic Analysis

  Harvey Wong, Lichuan Liu, Wenjun Ouyang, Yuzhong Deng, Matthew R. Wright and Cornelis E.C.A. Hop

  Journal of Pharmacology and Experimental Therapeutics June 2019, 369 (3) 406-418; DOI: https://doi.org/10.1124/jpet.118.255562
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  Beneficial Metabolic Effects of Mirabegron In Vitro and in High-Fat Diet-Induced Obese Mice

  Lei Hao, Sheyenne Scott, Mehrnaz Abbasi, Yujiao Zu, Md Shahjalal Hossain Khan, Yang Yang, Dayong Wu, Ling Zhao and Shu Wang

  Journal of Pharmacology and Experimental Therapeutics June 2019, 369 (3) 419-427; DOI: https://doi.org/10.1124/jpet.118.255778
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  Colony-Stimulating Factor-1 Antibody Lacnotuzumab in a Phase 1 Healthy Volunteer Study and Mechanistic Investigation of Safety Outcomes

  Francois Pognan, Philippe Couttet, Ivan Demin, Birgit Jaitner, Yinuo Pang, Ronenn Roubenoff, Esther Sutter, Yoav Timsit, Marie Anne Valentin, Beate Vogel, Gaetane Woerly, Armin Wolf and Ursula Schramm

  Journal of Pharmacology and Experimental Therapeutics June 2019, 369 (3) 428-442; DOI: https://doi.org/10.1124/jpet.118.254128
• Open Access

  AK106-001616, a Potent and Selective Inhibitor of Cytosolic Phospholipase A₂: In Vivo Efficacy for Inflammation, Neuropathic Pain, and Pulmonary Fibrosis

  Hirotomo Shimizu, Akitoshi Ito, Katsuhiko Sakurada, Junji Nakamura, Kosuke Tanaka, Masakazu Komatsu, Mineko Takeda, Kenichi Saito, Yukiko Endo, Tomohito Kozaki, Motoshi Shoda and Hiroshi Kuriyama

  Journal of Pharmacology and Experimental Therapeutics June 2019, 369 (3) 511-522; DOI: https://doi.org/10.1124/jpet.118.255034