Journal of Pharmacology and Experimental Therapeutics: 363 (2)

November 01, 2017; Volume 363,Issue 2

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Factors Contributing to the Antiviral Effectiveness of Tenofovir
Rachel A. Murphy and Monica A. Valentovic

Journal of Pharmacology and Experimental Therapeutics November 2017, 363 (2) 156-163; DOI: https://doi.org/10.1124/jpet.117.243139
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Cellular and Molecular Mechanisms of Calcium/Calmodulin-Dependent Protein Kinase II in Chronic Pain
Ya-Qun Zhou, Dai-Qiang Liu, Shu-Ping Chen, Jia Sun, Xue-Rong Zhou, Fang Luo, Yu-Ke Tian and Da-Wei Ye

Journal of Pharmacology and Experimental Therapeutics November 2017, 363 (2) 176-183; DOI: https://doi.org/10.1124/jpet.117.243048

Open Access
Histone Deacetylase Inhibitors Relax Mouse Aorta Partly through Their Inhibitory Action on L-Type Ca²⁺ Channels
Changbo Zheng, Mingkui Zhong, Zenghua Qi, Fan Shen, Qiannan Zhao, Lulu Wu, Yu Huang, Suk-Ying Tsang and Xiaoqiang Yao

Journal of Pharmacology and Experimental Therapeutics November 2017, 363 (2) 211-220; DOI: https://doi.org/10.1124/jpet.117.242685

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Depletion of Progranulin Reduces GluN2B-Containing NMDA Receptor Density, Tau Phosphorylation, and Dendritic Arborization in Mouse Primary Cortical Neurons
Francesca Longhena, Michela Zaltieri, Jessica Grigoletto, Gaia Faustini, Luca La Via, Roberta Ghidoni, Luisa Benussi, Cristina Missale, PierFranco Spano and Arianna Bellucci

Journal of Pharmacology and Experimental Therapeutics November 2017, 363 (2) 164-175; DOI: https://doi.org/10.1124/jpet.117.242164
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A Model of the Block of Voltage-Gated Potassium Kv4.2 Ionic Currents by 4-Aminopyridine
Steven J. Kehl

Journal of Pharmacology and Experimental Therapeutics November 2017, 363 (2) 184-195; DOI: https://doi.org/10.1124/jpet.117.243097
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Claudin-5-Binders Enhance Permeation of Solutes across the Blood-Brain Barrier in a Mammalian Model
Yosuke Hashimoto, Keisuke Shirakura, Yoshiaki Okada, Hiroyuki Takeda, Kohki Endo, Maki Tamura, Akihiro Watari, Yoshifusa Sadamura, Tatsuya Sawasaki, Takefumi Doi, Kiyohito Yagi and Masuo Kondoh

Journal of Pharmacology and Experimental Therapeutics November 2017, 363 (2) 275-283; DOI: https://doi.org/10.1124/jpet.117.243014

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Hybrid of DNA-targeting Chlorambucil with Pt(IV) Species to Reverse Drug Resistance
Feihong Chen, Gang Xu, Xiaodong Qin, Xiufeng Jin and Shaohua Gou

Journal of Pharmacology and Experimental Therapeutics November 2017, 363 (2) 221-239; DOI: https://doi.org/10.1124/jpet.117.243451

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Heterogeneous Binding and Central Nervous System Distribution of the Multitargeted Kinase Inhibitor Ponatinib Restrict Orthotopic Efficacy in a Patient-Derived Xenograft Model of Glioblastoma
Janice K. Laramy, Minjee Kim, Shiv K. Gupta, Karen E. Parrish, Shuangling Zhang, Katrina K. Bakken, Brett L. Carlson, Ann C. Mladek, Daniel J. Ma, Jann N. Sarkaria and William F. Elmquist

Journal of Pharmacology and Experimental Therapeutics November 2017, 363 (2) 136-147; DOI: https://doi.org/10.1124/jpet.117.243477
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Jadomycins Inhibit Type II Topoisomerases and Promote DNA Damage and Apoptosis in Multidrug-Resistant Triple-Negative Breast Cancer Cells
Steven R. Hall, Jay Toulany, Leah G. Bennett, Camilo F. Martinez-Farina, Andrew W. Robertson, David L. Jakeman and Kerry B. Goralski

Journal of Pharmacology and Experimental Therapeutics November 2017, 363 (2) 196-210; DOI: https://doi.org/10.1124/jpet.117.241125
Open Access
Acalabrutinib (ACP-196): A Covalent Bruton Tyrosine Kinase Inhibitor with a Differentiated Selectivity and In Vivo Potency Profile
Tjeerd Barf, Todd Covey, Raquel Izumi, Bas van de Kar, Michael Gulrajani, Bart van Lith, Maaike van Hoek, Edwin de Zwart, Diana Mittag, Dennis Demont, Saskia Verkaik, Fanny Krantz, Paul G. Pearson, Roger Ulrich and Allard Kaptein

Journal of Pharmacology and Experimental Therapeutics November 2017, 363 (2) 240-252; DOI: https://doi.org/10.1124/jpet.117.242909

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Upregulation of Epac-1 in Hepatic Stellate Cells by Prostaglandin E₂ in Liver Fibrosis Is Associated with Reduced Fibrogenesis
Marlies Schippers, Leonie Beljaars, Eduard Post, Sophie Lotersztajn, Catharina Reker-Smit, Bing Han, Pablo Munoz-Llancao, Martina Schmidt and Klaas Poelstra

Journal of Pharmacology and Experimental Therapeutics November 2017, 363 (2) 126-135; DOI: https://doi.org/10.1124/jpet.117.241646

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Genetic and Nongenetic Factors Associated with Protein Abundance of Flavin-Containing Monooxygenase 3 in Human Liver
Meijuan Xu, Deepak Kumar Bhatt, Catherine K. Yeung, Katrina G. Claw, Amarjit S. Chaudhry, Andrea Gaedigk, Robin E. Pearce, Ulrich Broeckel, Roger Gaedigk, Deborah A. Nickerson, Erin Schuetz, Allan E. Rettie, J. Steven Leeder, Kenneth E. Thummel and Bhagwat Prasad

Journal of Pharmacology and Experimental Therapeutics November 2017, 363 (2) 265-274; DOI: https://doi.org/10.1124/jpet.117.243113

Open Access
Adenylyl Cyclase 1 Is Required for Ethanol-Induced Locomotor Sensitization and Associated Increases in NMDA Receptor Phosphorylation and Function in the Dorsal Medial Striatum
Kelly E. Bosse, Max F. Oginsky, Laura L. Susick, Sailesh Ramalingam, Carrie R. Ferrario and Alana C. Conti

Journal of Pharmacology and Experimental Therapeutics November 2017, 363 (2) 148-155; DOI: https://doi.org/10.1124/jpet.117.242321
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FTBMT, a Novel and Selective GPR52 Agonist, Demonstrates Antipsychotic-Like and Procognitive Effects in Rodents, Revealing a Potential Therapeutic Agent for Schizophrenia
Keiji Nishiyama, Hirobumi Suzuki, Toshiya Harasawa, Noriko Suzuki, Emi Kurimoto, Takayuki Kawai, Minoru Maruyama, Hidetoshi Komatsu, Kensuke Sakuma, Yuji Shimizu and Masato Shimojo

Journal of Pharmacology and Experimental Therapeutics November 2017, 363 (2) 253-264; DOI: https://doi.org/10.1124/jpet.117.242925
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A Novel Bibenzyl Compound (20C) Protects Mice from 1-Methyl-4-Phenyl-1,2,3,6-Tetrahydropyridine/Probenecid Toxicity by Regulating the α-Synuclein–Related Inflammatory Response
Qiu-Shuang Zhang, Yang Heng, Ying Chen, Piao Luo, Lu Wen, Zhao Zhang, Yu-He Yuan and Nai-Hong Chen

Journal of Pharmacology and Experimental Therapeutics November 2017, 363 (2) 284-292; DOI: https://doi.org/10.1124/jpet.117.244020