Journal of Pharmacology and Experimental Therapeutics: 363 (1)

October 01, 2017; Volume 363,Issue 1

Minireviews

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Enhancing Studies of Pharmacodynamic Mechanisms via Measurements of Metabolic Flux: Fundamental Concepts and Guiding Principles for Using Stable Isotope Tracers
Natalie A. Daurio, Sheng-Ping Wang, Ying Chen, Haihong Zhou, David G. McLaren, Thomas P. Roddy, Douglas G. Johns, Denise Milot, Takhar Kasumov, Mark D. Erion, David E. Kelley and Stephen F. Previs

Journal of Pharmacology and Experimental Therapeutics October 2017, 363 (1) 80-91; DOI: https://doi.org/10.1124/jpet.117.241091

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Assessing the Value of the Zebrafish Conditioned Place Preference Model for Predicting Human Abuse Potential
A. J. Brock, S. M. G. Goody, A. N. Mead, A. Sudwarts, M.O. Parker and C.H. Brennan

Journal of Pharmacology and Experimental Therapeutics October 2017, 363 (1) 66-79; DOI: https://doi.org/10.1124/jpet.117.242628

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Docetaxel Reverses Pulmonary Vascular Remodeling by Decreasing Autophagy and Resolves Right Ventricular Fibrosis
Yasmine F. Ibrahim, Nataliia V. Shults, Vladyslava Rybka and Yuichiro J. Suzuki

Journal of Pharmacology and Experimental Therapeutics October 2017, 363 (1) 20-34; DOI: https://doi.org/10.1124/jpet.117.239921

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CXCR4-Specific Nanobodies as Potential Therapeutics for WHIM syndrome
Raymond H. de Wit, Raimond Heukers, Hendrik J. Brink, Angela Arsova, David Maussang, Pasquale Cutolo, Beatrijs Strubbe, Henry F. Vischer, Françoise Bachelerie and Martine J. Smit

Journal of Pharmacology and Experimental Therapeutics October 2017, 363 (1) 35-44; DOI: https://doi.org/10.1124/jpet.117.242735

Open Access
Novel Pathways of Ponatinib Disposition Catalyzed By CYP1A1 Involving Generation of Potentially Toxic Metabolites
De Lin, Rumen Kostov, Jeffrey T.-J. Huang, Colin J. Henderson and C. Roland Wolf

Journal of Pharmacology and Experimental Therapeutics October 2017, 363 (1) 12-19; DOI: https://doi.org/10.1124/jpet.117.243246

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New Peptide Inhibitor of Dipeptidyl Peptidase IV, EMDB-1 Extends the Half-Life of GLP-2 and Attenuates Colitis in Mice after Topical Administration
Maciej Salaga, Anna Mokrowiecka, Marta Zielinska, Ewa Malecka-Panas, Radzislaw Kordek, Elzbieta Kamysz and Jakub Fichna

Journal of Pharmacology and Experimental Therapeutics October 2017, 363 (1) 92-103; DOI: https://doi.org/10.1124/jpet.117.242586
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Characterization of the Potent, Selective Nrf2 Activator, 3-(Pyridin-3-Ylsulfonyl)-5-(Trifluoromethyl)-2H-Chromen-2-One, in Cellular and In Vivo Models of Pulmonary Oxidative Stress
John G. Yonchuk, Joseph P. Foley, Brian J. Bolognese, Gregory Logan, William E. Wixted, Jen-Pyng Kou, Diana G. Chalupowicz, Heidi G. Feldser, Yolanda Sanchez, Hong Nie, James F. Callahan, Jeffrey K. Kerns and Patricia L. Podolin

Journal of Pharmacology and Experimental Therapeutics October 2017, 363 (1) 114-125; DOI: https://doi.org/10.1124/jpet.117.241794

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Mechanistic Multi—Tissue Modeling of Glucocorticoid-Induced Leucine Zipper Regulation: Integrating Circadian Gene Expression with Receptor-Mediated Corticosteroid Pharmacodynamics
Vivaswath S. Ayyar, Debra C. DuBois, Richard R. Almon and William J. Jusko

Journal of Pharmacology and Experimental Therapeutics October 2017, 363 (1) 45-57; DOI: https://doi.org/10.1124/jpet.117.242990

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Ethanol Exposure Regulates Gabra1 Expression via Histone Deacetylation at the Promoter in Cultured Cortical Neurons
John Peyton Bohnsack, Vraj K. Patel and A. Leslie Morrow

Journal of Pharmacology and Experimental Therapeutics October 2017, 363 (1) 1-11; DOI: https://doi.org/10.1124/jpet.117.242446

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Urolithin A Mitigates Cisplatin-Induced Nephrotoxicity by Inhibiting Renal Inflammation and Apoptosis in an Experimental Rat Model
Melissa Guada, Raghu Ganugula, Manicka Vadhanam and Majeti N.V. Ravi Kumar

Journal of Pharmacology and Experimental Therapeutics October 2017, 363 (1) 58-65; DOI: https://doi.org/10.1124/jpet.117.242420
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NKTR-181: A Novel Mu-Opioid Analgesic with Inherently Low Abuse Potential
Takahiro Miyazaki, Irene Y. Choi, Werner Rubas, Neel K. Anand, Cherie Ali, Juli Evans, Hema Gursahani, Marlene Hennessy, Grace Kim, Daniel McWeeney, Juergen Pfeiffer, Phi Quach, David Gauvin, Timothy A. Riley, Jennifer A. Riggs, Kathleen Gogas, Jonathan Zalevsky and Stephen K. Doberstein

Journal of Pharmacology and Experimental Therapeutics October 2017, 363 (1) 104-113; DOI: https://doi.org/10.1124/jpet.117.243030