KVX-053, a Protein Tyrosine Phosphatase 4A3 inhibitor, ameliorates SARS‐CoV‐2 Spike protein subunit 1 - induced acute lung injury in mice

Pavel A Solopov; Ruben Manuel Luciano Colunga Biancatelli; Tierney Day; Betsy Gregory; Elizabeth R Sharlow; John S. Lazo; John D Catravas

doi:10.1124/jpet.124.002154

OtherGastrointestinal, Hepatic, Pulmonary, and Renal

KVX-053, a Protein Tyrosine Phosphatase 4A3 inhibitor, ameliorates SARS‐CoV‐2 Spike protein subunit 1 - induced acute lung injury in mice

Pavel A Solopov, Ruben Manuel Luciano Colunga Biancatelli, Tierney Day, Betsy Gregory, Elizabeth R Sharlow, John S. Lazo and John D Catravas

Journal of Pharmacology and Experimental Therapeutics August 23, 2024, JPET-AR-2024-002154; DOI: https://doi.org/10.1124/jpet.124.002154

Pavel A Solopov

1Old Dominion University, United States

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For correspondence: psolopov@odu.edu

Ruben Manuel Luciano Colunga Biancatelli

2Frank Reidy Reserach Center for Bioelectrics, Old Dominion University, United States

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Tierney Day

3Frank Reidy Research Center for Bioelectrics, Old Dominion University, United States

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Betsy Gregory

3Frank Reidy Research Center for Bioelectrics, Old Dominion University, United States

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Elizabeth R Sharlow

4Pharmacology, University of Virginia, United States

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John S. Lazo

4Pharmacology, University of Virginia, United States

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John D Catravas

5OLD DOMINION UNIVERSITY, United States

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Journal of Pharmacology and Experimental Therapeutics

Vol. 391, Issue 3

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OtherGastrointestinal, Hepatic, Pulmonary, and Renal

KVX-053 ameliorates SARS-CoV-2 S1SP-induced ALI

Pavel A Solopov, Ruben Manuel Luciano Colunga Biancatelli, Tierney Day, Betsy Gregory, Elizabeth R Sharlow, John S. Lazo and John D Catravas

Journal of Pharmacology and Experimental Therapeutics August 23, 2024, JPET-AR-2024-002154; DOI: https://doi.org/10.1124/jpet.124.002154

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OtherGastrointestinal, Hepatic, Pulmonary, and Renal

KVX-053 ameliorates SARS-CoV-2 S1SP-induced ALI

Pavel A Solopov, Ruben Manuel Luciano Colunga Biancatelli, Tierney Day, Betsy Gregory, Elizabeth R Sharlow, John S. Lazo and John D Catravas

Journal of Pharmacology and Experimental Therapeutics August 23, 2024, JPET-AR-2024-002154; DOI: https://doi.org/10.1124/jpet.124.002154

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KVX-053, a Protein Tyrosine Phosphatase 4A3 inhibitor, ameliorates SARS‐CoV‐2 Spike protein subunit 1 - induced acute lung injury in mice

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