OtherEndocrine and Diabetes
Initial pharmacological characterization of a major hydroxy metabolite of PF-5190457: inverse agonist activity of PF-6870961 at the ghrelin receptor
Sara L. Deschaine, Morten A. Hedegaard, Claire L. Pince, Mehdi Farokhnia, Jacob E Moose, Ingrid A Stock, Sravani Adusumalli, Fatemeh Akhlaghi, James L. Hougland, Agnieszka Sulima, Kenner C. Rice, George F. Koob, Leandro Vendruscolo, Birgitte Holst and Lorenzo Leggio
Journal of Pharmacology and Experimental Therapeutics February 22, 2023, JPET-AR-2022-001393; DOI: https://doi.org/10.1124/jpet.122.001393
Sara L. Deschaine
1Intramural Research Program, NIDA, NIH, United States
Morten A. Hedegaard
2University of Copenhagen, Denmark
Claire L. Pince
1Intramural Research Program, NIDA, NIH, United States
Mehdi Farokhnia
1Intramural Research Program, NIDA, NIH, United States
Jacob E Moose
3Syracuse University, United States
Ingrid A Stock
4Pfizer, Inc., United States
Sravani Adusumalli
5University of Rhode Island, United States
Fatemeh Akhlaghi
6Biomedical and Pharmaceutical Sciences, University of Rhode Island, United States
James L. Hougland
3Syracuse University, United States
Agnieszka Sulima
7Drug Design and Synthesis Section, Molecular Targets and Medications Discovery Branch, NIDA and NIAAA, United States
Kenner C. Rice
8NIDA/NIH, United States
George F. Koob
9National Institute on Alcohol Abuse and Alcoholism, United States
Leandro Vendruscolo
10NIH, United States
Birgitte Holst
11Laboratory of Molecular Pharmacology, University of Copenhagen, Denmark
Lorenzo Leggio
1Intramural Research Program, NIDA, NIH, United States
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In this issue
OtherEndocrine and Diabetes
PF-5190457 metabolite activity at the ghrelin receptor
Sara L. Deschaine, Morten A. Hedegaard, Claire L. Pince, Mehdi Farokhnia, Jacob E Moose, Ingrid A Stock, Sravani Adusumalli, Fatemeh Akhlaghi, James L. Hougland, Agnieszka Sulima, Kenner C. Rice, George F. Koob, Leandro Vendruscolo, Birgitte Holst and Lorenzo Leggio
Journal of Pharmacology and Experimental Therapeutics February 22, 2023, JPET-AR-2022-001393; DOI: https://doi.org/10.1124/jpet.122.001393
OtherEndocrine and Diabetes
PF-5190457 metabolite activity at the ghrelin receptor
Sara L. Deschaine, Morten A. Hedegaard, Claire L. Pince, Mehdi Farokhnia, Jacob E Moose, Ingrid A Stock, Sravani Adusumalli, Fatemeh Akhlaghi, James L. Hougland, Agnieszka Sulima, Kenner C. Rice, George F. Koob, Leandro Vendruscolo, Birgitte Holst and Lorenzo Leggio
Journal of Pharmacology and Experimental Therapeutics February 22, 2023, JPET-AR-2022-001393; DOI: https://doi.org/10.1124/jpet.122.001393
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