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Research ArticleNeuropharmacology

N-aryl piperazine metabotropic glutamate receptor 5 positive allosteric modulators possess efficacy in pre-clinical models of NMDA hypofunction and cognitive enhancement

Karen J Gregory, Elizabeth J Herman, Amy J Ramsey, Alexis S Hammond, Nellie E Byun, Shaun R Stauffer, Jason T Manka, Satyawan Jadhav, Thomas M Bridges, C. David Weaver, Colleen M Niswender, Thomas Steckler, Wilhelmus H. Drinkenburg, Abdellah Ahnaou, Hilde Lavreysen, Gregor J Macdonald, Jose M Bartolome, Claire Mackie, Brian J Hrupka, Marc G Caron, Tanya L Daigle, Craig W Lindsley, P. Jeffrey Conn and Carrie Kimberly Jones
Journal of Pharmacology and Experimental Therapeutics August 21, 2013, jpet.113.206623; DOI: https://doi.org/10.1124/jpet.113.206623

Article Information

jpet.113.206623
DOI 
https://doi.org/10.1124/jpet.113.206623
PubMed 
23965381
Published By 
American Society for Pharmacology and Experimental Therapeutics
Print ISSN 
0022-3565
Online ISSN 
1521-0103
History 
  • Published online August 21, 2013.

Article Versions

Copyright & Usage 
The American Society for Pharmacology and Experimental Therapeutics

Author Information

  1. Karen J Gregory1,
  2. Elizabeth J Herman2,
  3. Amy J Ramsey3,
  4. Alexis S Hammond2,
  5. Nellie E Byun1,
  6. Shaun R Stauffer2,
  7. Jason T Manka2,
  8. Satyawan Jadhav2,
  9. Thomas M Bridges1,
  10. C. David Weaver4,
  11. Colleen M Niswender1,
  12. Thomas Steckler5,
  13. Wilhelmus H. Drinkenburg5,
  14. Abdellah Ahnaou6,
  15. Hilde Lavreysen5,
  16. Gregor J Macdonald5,
  17. Jose M Bartolome5,
  18. Claire Mackie5,
  19. Brian J Hrupka5,
  20. Marc G Caron7,
  21. Tanya L Daigle7,
  22. Craig W Lindsley2,
  23. P. Jeffrey Conn2, and
  24. Carrie Kimberly Jones1,*
  1. 1 Vanderbilt University;
  2. 2 Vanderbilt University Medical Center;
  3. 3 University of Toronto;
  4. 4 Vanderbilt;
  5. 5 Johnson & Johnson Pharmaceutical Research and Development;
  6. 6 Johnson & Johnson Pharmaceutical Research and development;
  7. 7 Duke University
  1. ↵* Corresponding author; email: carrie.jones{at}vanderbilt.edu

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Research ArticleNeuropharmacology

N-aryl piperazine metabotropic glutamate receptor 5 positive allosteric modulators possess efficacy in pre-clinical models of NMDA hypofunction and cognitive enhancement

Karen J Gregory, Elizabeth J Herman, Amy J Ramsey, Alexis S Hammond, Nellie E Byun, Shaun R Stauffer, Jason T Manka, Satyawan Jadhav, Thomas M Bridges, C. David Weaver, Colleen M Niswender, Thomas Steckler, Wilhelmus H. Drinkenburg, Abdellah Ahnaou, Hilde Lavreysen, Gregor J Macdonald, Jose M Bartolome, Claire Mackie, Brian J Hrupka, Marc G Caron, Tanya L Daigle, Craig W Lindsley, P. Jeffrey Conn and Carrie Kimberly Jones
Journal of Pharmacology and Experimental Therapeutics August 21, 2013, jpet.113.206623; DOI: https://doi.org/10.1124/jpet.113.206623
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