Journal of Pharmacology and Experimental Therapeutics: 391 (1)

October 01, 2024; Volume 391,Issue 1

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Methocinnamox is a Potent and Long-Acting Antagonist that can Prevent and Reverse Opioid-Induced Respiratory Depression
James A. Carr and Daniel J. Morgan

Journal of Pharmacology and Experimental Therapeutics October 2024, 391 (1) 1-3; DOI: https://doi.org/10.1124/jpet.124.002205
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Comparison of the μ-Opioid Receptor Antagonists Methocinnamox and Naloxone to Reverse and Prevent the Ventilatory Depressant Effects of Fentanyl, Carfentanil, 3-Methylfentanyl, and Heroin in Male Rats
Takato Hiranita, Nicholas P. Ho and Charles P. France

Journal of Pharmacology and Experimental Therapeutics October 2024, 391 (1) 4-17; DOI: https://doi.org/10.1124/jpet.123.002032

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A “Furious” Effort to Develop Novel 3,4-Methylenedioxymethamphetamine-Like Therapeutics
William E. Fantegrossi and Brenda M. Gannon

Journal of Pharmacology and Experimental Therapeutics October 2024, 391 (1) 18-21; DOI: https://doi.org/10.1124/jpet.124.002183
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Novel Benzofuran Derivatives Induce Monoamine Release and Substitute for the Discriminative Stimulus Effects of 3,4-Methylenedioxymethamphetamine
Candace B. Johnson, Donna Walther, Matthew J. Baggott, Lisa E. Baker and Michael H. Baumann

Journal of Pharmacology and Experimental Therapeutics October 2024, 391 (1) 22-29; DOI: https://doi.org/10.1124/jpet.123.001837

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The Effects of Eating a Traditional High Fat/High Carbohydrate or a Ketogenic Diet on Sensitivity of Female Rats to Morphine
Nina M. Beltran, Alyssa N. Parra, Ana Paulina Serrano, Jazmin Castillo, Isabella M. Castro, Madeline K. Elsey, Vanessa Minervini and Katherine M. Serafine

Journal of Pharmacology and Experimental Therapeutics October 2024, 391 (1) 30-38; DOI: https://doi.org/10.1124/jpet.124.002188

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Effect of Vascular Senescence on the Efficacy and Safety of Warfarin: Insights from Rat Models and a Prospective Cohort Study
Haobin Li, Jing Liu, Qing Liang, Yan Yu and Guangchun Sun

Journal of Pharmacology and Experimental Therapeutics October 2024, 391 (1) 39-50; DOI: https://doi.org/10.1124/jpet.124.002265

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Aloperine Attenuates Hepatic Ischemia/Reperfusion-Induced Liver Injury via STAT-3 Signaling in a Murine Model
Shichao Wei, Junshen Xiao, Feng Ju, Jiaxue Li, Ting Liu and Zhaoyang Hu

Journal of Pharmacology and Experimental Therapeutics October 2024, 391 (1) 51-63; DOI: https://doi.org/10.1124/jpet.123.001992

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Comparison of the Genomic Activity of an EP₄-Receptor and β₂-Adrenoceptor Agonist in BEAS-2B Human Bronchial Epithelial Cells: In Search of Compartmentalized, cAMP-Dependent Gene Expression
Radhika Joshi, Tamkeen U. Paracha, Mahmoud M. Mostafa, Andrew J. Thorne, Varuna Jayasinghe, Dong Yan, Omar Hamed, Robert Newton and Mark A. Giembycz

Journal of Pharmacology and Experimental Therapeutics October 2024, 391 (1) 64-81; DOI: https://doi.org/10.1124/jpet.124.002226

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Dysregulation of Human Hepatic Drug Transporters by Proinflammatory Cytokines
Tianran Hao, Yik Pui Tsang, Mengyue Yin, Qingcheng Mao and Jashvant D. Unadkat

Journal of Pharmacology and Experimental Therapeutics October 2024, 391 (1) 82-90; DOI: https://doi.org/10.1124/jpet.123.002019
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Lenacapavir Exhibits Atropisomerism—Mechanistic Pharmacokinetics and Disposition Studies of Lenacapavir Reveal Intestinal Excretion as a Major Clearance Pathway
Jim Zheng, Bing Lu, Gavin Carr, Judy Mwangi, Kelly Wang, Jia Hao, Kelly McLennan Staiger, Nathan Kozon, Bernard P. Murray, Mohammad Bashir, Mark A. Gohdes, Winston C. Tse, Scott Schroeder, Michael Graupe, John O. Link, Jungjoo Yoon, Anna Chiu, William Rowe, Bill J. Smith and Raju Subramanian

Journal of Pharmacology and Experimental Therapeutics October 2024, 391 (1) 91-103; DOI: https://doi.org/10.1124/jpet.124.002302

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Levetiracetam Prevents Neurophysiological Changes and Preserves Cognitive Function in the Human Immunodeficiency Virus (HIV)-1 Transactivator of Transcription Transgenic Mouse Model of HIV-Associated Neurocognitive Disorder
Ashley N. Ewens, Alexander Pilski, Shayne D. Hastings, Chris Krook-Magnuson, Steven M. Graves, Esther Krook-Magnuson and Stanley A. Thayer

Journal of Pharmacology and Experimental Therapeutics October 2024, 391 (1) 104-118; DOI: https://doi.org/10.1124/jpet.124.002272

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Primaquine-5,6-Orthoquinone Is Directly Hemolytic to Older G6PD Deficient RBCs in a Humanized Mouse Model
Karolina H. Dziewulska-Cronk, Julie A. Reisz, Ariel M. Hay, Travis Nemkov, Francesca I. Cendali, Aaron Issaian, Derek R. Lamb, Mitasha S. Palha, Eric A. Legenzov, Joseph P.Y. Kao, Larry A. Walker, Babu L. Tekwani, Paul W. Buehler, Angelo D’Alessandro and James C. Zimring

Journal of Pharmacology and Experimental Therapeutics October 2024, 391 (1) 119-129; DOI: https://doi.org/10.1124/jpet.124.002218