Department of Pharmacokinetics, Dynamics, Metabolism & Bioanalytics, Merck & Co., Inc., West Point, Pennsylvania (M.K.L.); Department of Pharmacology & Toxicology, Temerty Faculty of Medicine, University of Toronto, Toronto, Ontario (C.A.M.); Department of Experimental and Clinical Pharmacology, College of Pharmacy, University of Minnesota, Minneapolis-Saint Paul, Minnesota (C.D.P.); and Department of Anesthesiology, Perioperative and Pain Medicine, School of Medicine, Stanford University, Stanford, California (F.R., E.R.G.)

Department of Pharmacokinetics, Dynamics, Metabolism & Bioanalytics, Merck & Co., Inc., West Point, Pennsylvania (M.K.L.); Department of Pharmacology & Toxicology, Temerty Faculty of Medicine, University of Toronto, Toronto, Ontario (C.A.M.); Department of Experimental and Clinical Pharmacology, College of Pharmacy, University of Minnesota, Minneapolis-Saint Paul, Minnesota (C.D.P.); and Department of Anesthesiology, Perioperative and Pain Medicine, School of Medicine, Stanford University, Stanford, California (F.R., E.R.G.)

Department of Pharmacokinetics, Dynamics, Metabolism & Bioanalytics, Merck & Co., Inc., West Point, Pennsylvania (M.K.L.); Department of Pharmacology & Toxicology, Temerty Faculty of Medicine, University of Toronto, Toronto, Ontario (C.A.M.); Department of Experimental and Clinical Pharmacology, College of Pharmacy, University of Minnesota, Minneapolis-Saint Paul, Minnesota (C.D.P.); and Department of Anesthesiology, Perioperative and Pain Medicine, School of Medicine, Stanford University, Stanford, California (F.R., E.R.G.)

Department of Pharmacokinetics, Dynamics, Metabolism & Bioanalytics, Merck & Co., Inc., West Point, Pennsylvania (M.K.L.); Department of Pharmacology & Toxicology, Temerty Faculty of Medicine, University of Toronto, Toronto, Ontario (C.A.M.); Department of Experimental and Clinical Pharmacology, College of Pharmacy, University of Minnesota, Minneapolis-Saint Paul, Minnesota (C.D.P.); and Department of Anesthesiology, Perioperative and Pain Medicine, School of Medicine, Stanford University, Stanford, California (F.R., E.R.G.)

Department of Pharmacokinetics, Dynamics, Metabolism & Bioanalytics, Merck & Co., Inc., West Point, Pennsylvania (M.K.L.); Department of Pharmacology & Toxicology, Temerty Faculty of Medicine, University of Toronto, Toronto, Ontario (C.A.M.); Department of Experimental and Clinical Pharmacology, College of Pharmacy, University of Minnesota, Minneapolis-Saint Paul, Minnesota (C.D.P.); and Department of Anesthesiology, Perioperative and Pain Medicine, School of Medicine, Stanford University, Stanford, California (F.R., E.R.G.)