Centre for Applied Pharmacokinetic Research, School of Health Sciences, University of Manchester, United Kingdom (S.B., K.O., A.G.); Non-Clinical PKPD, UCB, Slough, United Kingdom (K.M.); and Pharmaceutical Candidate Optimization, Bristol-Myers Squibb, Princeton, New Jersey (H.S., W.G.H.)

Centre for Applied Pharmacokinetic Research, School of Health Sciences, University of Manchester, United Kingdom (S.B., K.O., A.G.); Non-Clinical PKPD, UCB, Slough, United Kingdom (K.M.); and Pharmaceutical Candidate Optimization, Bristol-Myers Squibb, Princeton, New Jersey (H.S., W.G.H.)

Centre for Applied Pharmacokinetic Research, School of Health Sciences, University of Manchester, United Kingdom (S.B., K.O., A.G.); Non-Clinical PKPD, UCB, Slough, United Kingdom (K.M.); and Pharmaceutical Candidate Optimization, Bristol-Myers Squibb, Princeton, New Jersey (H.S., W.G.H.)

Centre for Applied Pharmacokinetic Research, School of Health Sciences, University of Manchester, United Kingdom (S.B., K.O., A.G.); Non-Clinical PKPD, UCB, Slough, United Kingdom (K.M.); and Pharmaceutical Candidate Optimization, Bristol-Myers Squibb, Princeton, New Jersey (H.S., W.G.H.)

Centre for Applied Pharmacokinetic Research, School of Health Sciences, University of Manchester, United Kingdom (S.B., K.O., A.G.); Non-Clinical PKPD, UCB, Slough, United Kingdom (K.M.); and Pharmaceutical Candidate Optimization, Bristol-Myers Squibb, Princeton, New Jersey (H.S., W.G.H.)

Centre for Applied Pharmacokinetic Research, School of Health Sciences, University of Manchester, United Kingdom (S.B., K.O., A.G.); Non-Clinical PKPD, UCB, Slough, United Kingdom (K.M.); and Pharmaceutical Candidate Optimization, Bristol-Myers Squibb, Princeton, New Jersey (H.S., W.G.H.)