Research ArticleInflammation, Immunopharmacology, and Asthma
NLRP3 Inflammasome Involvement in the Organ Damage and Impaired Spermatogenesis Induced by Testicular Ischemia and Reperfusion in Mice
Letteria Minutoli, Pietro Antonuccio, Natasha Irrera, Mariagrazia Rinaldi, Alessandra Bitto, Herbert Marini, Gabriele Pizzino, Carmelo Romeo, Antonina Pisani, Giuseppe Santoro, Domenico Puzzolo, Carlo Magno, Francesco Squadrito, Antonio Micali and Domenica Altavilla
Journal of Pharmacology and Experimental Therapeutics December 2015, 355 (3) 370-380; DOI: https://doi.org/10.1124/jpet.115.226936
Letteria Minutoli
Department of Clinical and Experimental Medicine, University of Messina, Azienda Ospedaliera Universitaria Policlinico “G. Martino”, Messina, Italy (L.M., N.I., M.R., A.B., H.M., G.P., F.S.); Department of Paediatric, Gynaecological, Microbiological, and Biomedical Sciences, University of Messina, Azienda Ospedaliera Universitaria Policlinico “G. Martino”, Messina, Italy (P.A., C.R., D.A.); Department of Biomedical Sciences and Morphofunctional Imaging, University of Messina, Azienda Ospedaliera Universitaria Policlinico “G. Martino”, Messina, Italy (A.P., G.S., D.P., A.M.); and Department of Human Pathology, University of Messina, Azienda Ospedaliera Universitaria Policlinico “G. Martino”, Messina, Italy (C.M.)
Pietro Antonuccio
Department of Clinical and Experimental Medicine, University of Messina, Azienda Ospedaliera Universitaria Policlinico “G. Martino”, Messina, Italy (L.M., N.I., M.R., A.B., H.M., G.P., F.S.); Department of Paediatric, Gynaecological, Microbiological, and Biomedical Sciences, University of Messina, Azienda Ospedaliera Universitaria Policlinico “G. Martino”, Messina, Italy (P.A., C.R., D.A.); Department of Biomedical Sciences and Morphofunctional Imaging, University of Messina, Azienda Ospedaliera Universitaria Policlinico “G. Martino”, Messina, Italy (A.P., G.S., D.P., A.M.); and Department of Human Pathology, University of Messina, Azienda Ospedaliera Universitaria Policlinico “G. Martino”, Messina, Italy (C.M.)
Natasha Irrera
Department of Clinical and Experimental Medicine, University of Messina, Azienda Ospedaliera Universitaria Policlinico “G. Martino”, Messina, Italy (L.M., N.I., M.R., A.B., H.M., G.P., F.S.); Department of Paediatric, Gynaecological, Microbiological, and Biomedical Sciences, University of Messina, Azienda Ospedaliera Universitaria Policlinico “G. Martino”, Messina, Italy (P.A., C.R., D.A.); Department of Biomedical Sciences and Morphofunctional Imaging, University of Messina, Azienda Ospedaliera Universitaria Policlinico “G. Martino”, Messina, Italy (A.P., G.S., D.P., A.M.); and Department of Human Pathology, University of Messina, Azienda Ospedaliera Universitaria Policlinico “G. Martino”, Messina, Italy (C.M.)
Mariagrazia Rinaldi
Department of Clinical and Experimental Medicine, University of Messina, Azienda Ospedaliera Universitaria Policlinico “G. Martino”, Messina, Italy (L.M., N.I., M.R., A.B., H.M., G.P., F.S.); Department of Paediatric, Gynaecological, Microbiological, and Biomedical Sciences, University of Messina, Azienda Ospedaliera Universitaria Policlinico “G. Martino”, Messina, Italy (P.A., C.R., D.A.); Department of Biomedical Sciences and Morphofunctional Imaging, University of Messina, Azienda Ospedaliera Universitaria Policlinico “G. Martino”, Messina, Italy (A.P., G.S., D.P., A.M.); and Department of Human Pathology, University of Messina, Azienda Ospedaliera Universitaria Policlinico “G. Martino”, Messina, Italy (C.M.)
Alessandra Bitto
Department of Clinical and Experimental Medicine, University of Messina, Azienda Ospedaliera Universitaria Policlinico “G. Martino”, Messina, Italy (L.M., N.I., M.R., A.B., H.M., G.P., F.S.); Department of Paediatric, Gynaecological, Microbiological, and Biomedical Sciences, University of Messina, Azienda Ospedaliera Universitaria Policlinico “G. Martino”, Messina, Italy (P.A., C.R., D.A.); Department of Biomedical Sciences and Morphofunctional Imaging, University of Messina, Azienda Ospedaliera Universitaria Policlinico “G. Martino”, Messina, Italy (A.P., G.S., D.P., A.M.); and Department of Human Pathology, University of Messina, Azienda Ospedaliera Universitaria Policlinico “G. Martino”, Messina, Italy (C.M.)
Herbert Marini
Department of Clinical and Experimental Medicine, University of Messina, Azienda Ospedaliera Universitaria Policlinico “G. Martino”, Messina, Italy (L.M., N.I., M.R., A.B., H.M., G.P., F.S.); Department of Paediatric, Gynaecological, Microbiological, and Biomedical Sciences, University of Messina, Azienda Ospedaliera Universitaria Policlinico “G. Martino”, Messina, Italy (P.A., C.R., D.A.); Department of Biomedical Sciences and Morphofunctional Imaging, University of Messina, Azienda Ospedaliera Universitaria Policlinico “G. Martino”, Messina, Italy (A.P., G.S., D.P., A.M.); and Department of Human Pathology, University of Messina, Azienda Ospedaliera Universitaria Policlinico “G. Martino”, Messina, Italy (C.M.)
Gabriele Pizzino
Department of Clinical and Experimental Medicine, University of Messina, Azienda Ospedaliera Universitaria Policlinico “G. Martino”, Messina, Italy (L.M., N.I., M.R., A.B., H.M., G.P., F.S.); Department of Paediatric, Gynaecological, Microbiological, and Biomedical Sciences, University of Messina, Azienda Ospedaliera Universitaria Policlinico “G. Martino”, Messina, Italy (P.A., C.R., D.A.); Department of Biomedical Sciences and Morphofunctional Imaging, University of Messina, Azienda Ospedaliera Universitaria Policlinico “G. Martino”, Messina, Italy (A.P., G.S., D.P., A.M.); and Department of Human Pathology, University of Messina, Azienda Ospedaliera Universitaria Policlinico “G. Martino”, Messina, Italy (C.M.)
Carmelo Romeo
Department of Clinical and Experimental Medicine, University of Messina, Azienda Ospedaliera Universitaria Policlinico “G. Martino”, Messina, Italy (L.M., N.I., M.R., A.B., H.M., G.P., F.S.); Department of Paediatric, Gynaecological, Microbiological, and Biomedical Sciences, University of Messina, Azienda Ospedaliera Universitaria Policlinico “G. Martino”, Messina, Italy (P.A., C.R., D.A.); Department of Biomedical Sciences and Morphofunctional Imaging, University of Messina, Azienda Ospedaliera Universitaria Policlinico “G. Martino”, Messina, Italy (A.P., G.S., D.P., A.M.); and Department of Human Pathology, University of Messina, Azienda Ospedaliera Universitaria Policlinico “G. Martino”, Messina, Italy (C.M.)
Antonina Pisani
Department of Clinical and Experimental Medicine, University of Messina, Azienda Ospedaliera Universitaria Policlinico “G. Martino”, Messina, Italy (L.M., N.I., M.R., A.B., H.M., G.P., F.S.); Department of Paediatric, Gynaecological, Microbiological, and Biomedical Sciences, University of Messina, Azienda Ospedaliera Universitaria Policlinico “G. Martino”, Messina, Italy (P.A., C.R., D.A.); Department of Biomedical Sciences and Morphofunctional Imaging, University of Messina, Azienda Ospedaliera Universitaria Policlinico “G. Martino”, Messina, Italy (A.P., G.S., D.P., A.M.); and Department of Human Pathology, University of Messina, Azienda Ospedaliera Universitaria Policlinico “G. Martino”, Messina, Italy (C.M.)
Giuseppe Santoro
Department of Clinical and Experimental Medicine, University of Messina, Azienda Ospedaliera Universitaria Policlinico “G. Martino”, Messina, Italy (L.M., N.I., M.R., A.B., H.M., G.P., F.S.); Department of Paediatric, Gynaecological, Microbiological, and Biomedical Sciences, University of Messina, Azienda Ospedaliera Universitaria Policlinico “G. Martino”, Messina, Italy (P.A., C.R., D.A.); Department of Biomedical Sciences and Morphofunctional Imaging, University of Messina, Azienda Ospedaliera Universitaria Policlinico “G. Martino”, Messina, Italy (A.P., G.S., D.P., A.M.); and Department of Human Pathology, University of Messina, Azienda Ospedaliera Universitaria Policlinico “G. Martino”, Messina, Italy (C.M.)
Domenico Puzzolo
Department of Clinical and Experimental Medicine, University of Messina, Azienda Ospedaliera Universitaria Policlinico “G. Martino”, Messina, Italy (L.M., N.I., M.R., A.B., H.M., G.P., F.S.); Department of Paediatric, Gynaecological, Microbiological, and Biomedical Sciences, University of Messina, Azienda Ospedaliera Universitaria Policlinico “G. Martino”, Messina, Italy (P.A., C.R., D.A.); Department of Biomedical Sciences and Morphofunctional Imaging, University of Messina, Azienda Ospedaliera Universitaria Policlinico “G. Martino”, Messina, Italy (A.P., G.S., D.P., A.M.); and Department of Human Pathology, University of Messina, Azienda Ospedaliera Universitaria Policlinico “G. Martino”, Messina, Italy (C.M.)
Carlo Magno
Department of Clinical and Experimental Medicine, University of Messina, Azienda Ospedaliera Universitaria Policlinico “G. Martino”, Messina, Italy (L.M., N.I., M.R., A.B., H.M., G.P., F.S.); Department of Paediatric, Gynaecological, Microbiological, and Biomedical Sciences, University of Messina, Azienda Ospedaliera Universitaria Policlinico “G. Martino”, Messina, Italy (P.A., C.R., D.A.); Department of Biomedical Sciences and Morphofunctional Imaging, University of Messina, Azienda Ospedaliera Universitaria Policlinico “G. Martino”, Messina, Italy (A.P., G.S., D.P., A.M.); and Department of Human Pathology, University of Messina, Azienda Ospedaliera Universitaria Policlinico “G. Martino”, Messina, Italy (C.M.)
Francesco Squadrito
Department of Clinical and Experimental Medicine, University of Messina, Azienda Ospedaliera Universitaria Policlinico “G. Martino”, Messina, Italy (L.M., N.I., M.R., A.B., H.M., G.P., F.S.); Department of Paediatric, Gynaecological, Microbiological, and Biomedical Sciences, University of Messina, Azienda Ospedaliera Universitaria Policlinico “G. Martino”, Messina, Italy (P.A., C.R., D.A.); Department of Biomedical Sciences and Morphofunctional Imaging, University of Messina, Azienda Ospedaliera Universitaria Policlinico “G. Martino”, Messina, Italy (A.P., G.S., D.P., A.M.); and Department of Human Pathology, University of Messina, Azienda Ospedaliera Universitaria Policlinico “G. Martino”, Messina, Italy (C.M.)
Antonio Micali
Department of Clinical and Experimental Medicine, University of Messina, Azienda Ospedaliera Universitaria Policlinico “G. Martino”, Messina, Italy (L.M., N.I., M.R., A.B., H.M., G.P., F.S.); Department of Paediatric, Gynaecological, Microbiological, and Biomedical Sciences, University of Messina, Azienda Ospedaliera Universitaria Policlinico “G. Martino”, Messina, Italy (P.A., C.R., D.A.); Department of Biomedical Sciences and Morphofunctional Imaging, University of Messina, Azienda Ospedaliera Universitaria Policlinico “G. Martino”, Messina, Italy (A.P., G.S., D.P., A.M.); and Department of Human Pathology, University of Messina, Azienda Ospedaliera Universitaria Policlinico “G. Martino”, Messina, Italy (C.M.)
Domenica Altavilla
Department of Clinical and Experimental Medicine, University of Messina, Azienda Ospedaliera Universitaria Policlinico “G. Martino”, Messina, Italy (L.M., N.I., M.R., A.B., H.M., G.P., F.S.); Department of Paediatric, Gynaecological, Microbiological, and Biomedical Sciences, University of Messina, Azienda Ospedaliera Universitaria Policlinico “G. Martino”, Messina, Italy (P.A., C.R., D.A.); Department of Biomedical Sciences and Morphofunctional Imaging, University of Messina, Azienda Ospedaliera Universitaria Policlinico “G. Martino”, Messina, Italy (A.P., G.S., D.P., A.M.); and Department of Human Pathology, University of Messina, Azienda Ospedaliera Universitaria Policlinico “G. Martino”, Messina, Italy (C.M.)
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In this issue
Research ArticleInflammation, Immunopharmacology, and Asthma
Role of NLRP3 Inflammasome in Testicular Ischemia
Letteria Minutoli, Pietro Antonuccio, Natasha Irrera, Mariagrazia Rinaldi, Alessandra Bitto, Herbert Marini, Gabriele Pizzino, Carmelo Romeo, Antonina Pisani, Giuseppe Santoro, Domenico Puzzolo, Carlo Magno, Francesco Squadrito, Antonio Micali and Domenica Altavilla
Journal of Pharmacology and Experimental Therapeutics December 1, 2015, 355 (3) 370-380; DOI: https://doi.org/10.1124/jpet.115.226936
Research ArticleInflammation, Immunopharmacology, and Asthma
Role of NLRP3 Inflammasome in Testicular Ischemia
Letteria Minutoli, Pietro Antonuccio, Natasha Irrera, Mariagrazia Rinaldi, Alessandra Bitto, Herbert Marini, Gabriele Pizzino, Carmelo Romeo, Antonina Pisani, Giuseppe Santoro, Domenico Puzzolo, Carlo Magno, Francesco Squadrito, Antonio Micali and Domenica Altavilla
Journal of Pharmacology and Experimental Therapeutics December 1, 2015, 355 (3) 370-380; DOI: https://doi.org/10.1124/jpet.115.226936
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