Research ArticleMetabolism, Transport, and Pharmacogenomics
Marked Alteration of Rosuvastatin Pharmacokinetics in Healthy Chinese with ABCG2 34G>A and 421C>A Homozygote or Compound Heterozygote
Zirui Wan, Guo Wang, Tailin Li, Biaobo Xu, Qi Pei, Yan Peng, Hong Sun, Lijuan Cheng, Ying Zeng, Guoping Yang and Yuan-Shan Zhu
Journal of Pharmacology and Experimental Therapeutics September 2015, 354 (3) 310-315; DOI: https://doi.org/10.1124/jpet.115.225045
Zirui Wan
Department of Clinical Pharmacology of Xiangya Hospital, Central South University, Changsha, Hunan, China (Z.W., G.W., T.L., B.X., Y.P., H.S., Y.Z., Y.-S.Z.); Institute of Clinical Pharmacology, Central South University, Changsha, Hunan, China (Z.W., G.W., T.L., B.X., Y.P., H.S., Y.Z., Y.-S.Z.); Hunan Key Laboratory of Pharmacogenetics, Changsha, Hunan, China (Z.W., G.W., T.L., B.X., Y.P., H.S., Y.Z., Y.-S.Z.); Department of Pharmacy, Third Xiangya Hospital, Central South University, Changsha, Hunan, China (Q.P., G.Y.); Department of Biochemistry and Molecular Biology, Hunan University of Chinese Medicine, Changsha, Hunan, China (L.C.); and Beijing Chao-Yang Hospital, Capital Medical University, Beijing, China (Z.W.)
Guo Wang
Department of Clinical Pharmacology of Xiangya Hospital, Central South University, Changsha, Hunan, China (Z.W., G.W., T.L., B.X., Y.P., H.S., Y.Z., Y.-S.Z.); Institute of Clinical Pharmacology, Central South University, Changsha, Hunan, China (Z.W., G.W., T.L., B.X., Y.P., H.S., Y.Z., Y.-S.Z.); Hunan Key Laboratory of Pharmacogenetics, Changsha, Hunan, China (Z.W., G.W., T.L., B.X., Y.P., H.S., Y.Z., Y.-S.Z.); Department of Pharmacy, Third Xiangya Hospital, Central South University, Changsha, Hunan, China (Q.P., G.Y.); Department of Biochemistry and Molecular Biology, Hunan University of Chinese Medicine, Changsha, Hunan, China (L.C.); and Beijing Chao-Yang Hospital, Capital Medical University, Beijing, China (Z.W.)
Tailin Li
Department of Clinical Pharmacology of Xiangya Hospital, Central South University, Changsha, Hunan, China (Z.W., G.W., T.L., B.X., Y.P., H.S., Y.Z., Y.-S.Z.); Institute of Clinical Pharmacology, Central South University, Changsha, Hunan, China (Z.W., G.W., T.L., B.X., Y.P., H.S., Y.Z., Y.-S.Z.); Hunan Key Laboratory of Pharmacogenetics, Changsha, Hunan, China (Z.W., G.W., T.L., B.X., Y.P., H.S., Y.Z., Y.-S.Z.); Department of Pharmacy, Third Xiangya Hospital, Central South University, Changsha, Hunan, China (Q.P., G.Y.); Department of Biochemistry and Molecular Biology, Hunan University of Chinese Medicine, Changsha, Hunan, China (L.C.); and Beijing Chao-Yang Hospital, Capital Medical University, Beijing, China (Z.W.)
Biaobo Xu
Department of Clinical Pharmacology of Xiangya Hospital, Central South University, Changsha, Hunan, China (Z.W., G.W., T.L., B.X., Y.P., H.S., Y.Z., Y.-S.Z.); Institute of Clinical Pharmacology, Central South University, Changsha, Hunan, China (Z.W., G.W., T.L., B.X., Y.P., H.S., Y.Z., Y.-S.Z.); Hunan Key Laboratory of Pharmacogenetics, Changsha, Hunan, China (Z.W., G.W., T.L., B.X., Y.P., H.S., Y.Z., Y.-S.Z.); Department of Pharmacy, Third Xiangya Hospital, Central South University, Changsha, Hunan, China (Q.P., G.Y.); Department of Biochemistry and Molecular Biology, Hunan University of Chinese Medicine, Changsha, Hunan, China (L.C.); and Beijing Chao-Yang Hospital, Capital Medical University, Beijing, China (Z.W.)
Qi Pei
Department of Clinical Pharmacology of Xiangya Hospital, Central South University, Changsha, Hunan, China (Z.W., G.W., T.L., B.X., Y.P., H.S., Y.Z., Y.-S.Z.); Institute of Clinical Pharmacology, Central South University, Changsha, Hunan, China (Z.W., G.W., T.L., B.X., Y.P., H.S., Y.Z., Y.-S.Z.); Hunan Key Laboratory of Pharmacogenetics, Changsha, Hunan, China (Z.W., G.W., T.L., B.X., Y.P., H.S., Y.Z., Y.-S.Z.); Department of Pharmacy, Third Xiangya Hospital, Central South University, Changsha, Hunan, China (Q.P., G.Y.); Department of Biochemistry and Molecular Biology, Hunan University of Chinese Medicine, Changsha, Hunan, China (L.C.); and Beijing Chao-Yang Hospital, Capital Medical University, Beijing, China (Z.W.)
Yan Peng
Department of Clinical Pharmacology of Xiangya Hospital, Central South University, Changsha, Hunan, China (Z.W., G.W., T.L., B.X., Y.P., H.S., Y.Z., Y.-S.Z.); Institute of Clinical Pharmacology, Central South University, Changsha, Hunan, China (Z.W., G.W., T.L., B.X., Y.P., H.S., Y.Z., Y.-S.Z.); Hunan Key Laboratory of Pharmacogenetics, Changsha, Hunan, China (Z.W., G.W., T.L., B.X., Y.P., H.S., Y.Z., Y.-S.Z.); Department of Pharmacy, Third Xiangya Hospital, Central South University, Changsha, Hunan, China (Q.P., G.Y.); Department of Biochemistry and Molecular Biology, Hunan University of Chinese Medicine, Changsha, Hunan, China (L.C.); and Beijing Chao-Yang Hospital, Capital Medical University, Beijing, China (Z.W.)
Hong Sun
Department of Clinical Pharmacology of Xiangya Hospital, Central South University, Changsha, Hunan, China (Z.W., G.W., T.L., B.X., Y.P., H.S., Y.Z., Y.-S.Z.); Institute of Clinical Pharmacology, Central South University, Changsha, Hunan, China (Z.W., G.W., T.L., B.X., Y.P., H.S., Y.Z., Y.-S.Z.); Hunan Key Laboratory of Pharmacogenetics, Changsha, Hunan, China (Z.W., G.W., T.L., B.X., Y.P., H.S., Y.Z., Y.-S.Z.); Department of Pharmacy, Third Xiangya Hospital, Central South University, Changsha, Hunan, China (Q.P., G.Y.); Department of Biochemistry and Molecular Biology, Hunan University of Chinese Medicine, Changsha, Hunan, China (L.C.); and Beijing Chao-Yang Hospital, Capital Medical University, Beijing, China (Z.W.)
Lijuan Cheng
Department of Clinical Pharmacology of Xiangya Hospital, Central South University, Changsha, Hunan, China (Z.W., G.W., T.L., B.X., Y.P., H.S., Y.Z., Y.-S.Z.); Institute of Clinical Pharmacology, Central South University, Changsha, Hunan, China (Z.W., G.W., T.L., B.X., Y.P., H.S., Y.Z., Y.-S.Z.); Hunan Key Laboratory of Pharmacogenetics, Changsha, Hunan, China (Z.W., G.W., T.L., B.X., Y.P., H.S., Y.Z., Y.-S.Z.); Department of Pharmacy, Third Xiangya Hospital, Central South University, Changsha, Hunan, China (Q.P., G.Y.); Department of Biochemistry and Molecular Biology, Hunan University of Chinese Medicine, Changsha, Hunan, China (L.C.); and Beijing Chao-Yang Hospital, Capital Medical University, Beijing, China (Z.W.)
Ying Zeng
Department of Clinical Pharmacology of Xiangya Hospital, Central South University, Changsha, Hunan, China (Z.W., G.W., T.L., B.X., Y.P., H.S., Y.Z., Y.-S.Z.); Institute of Clinical Pharmacology, Central South University, Changsha, Hunan, China (Z.W., G.W., T.L., B.X., Y.P., H.S., Y.Z., Y.-S.Z.); Hunan Key Laboratory of Pharmacogenetics, Changsha, Hunan, China (Z.W., G.W., T.L., B.X., Y.P., H.S., Y.Z., Y.-S.Z.); Department of Pharmacy, Third Xiangya Hospital, Central South University, Changsha, Hunan, China (Q.P., G.Y.); Department of Biochemistry and Molecular Biology, Hunan University of Chinese Medicine, Changsha, Hunan, China (L.C.); and Beijing Chao-Yang Hospital, Capital Medical University, Beijing, China (Z.W.)
Guoping Yang
Department of Clinical Pharmacology of Xiangya Hospital, Central South University, Changsha, Hunan, China (Z.W., G.W., T.L., B.X., Y.P., H.S., Y.Z., Y.-S.Z.); Institute of Clinical Pharmacology, Central South University, Changsha, Hunan, China (Z.W., G.W., T.L., B.X., Y.P., H.S., Y.Z., Y.-S.Z.); Hunan Key Laboratory of Pharmacogenetics, Changsha, Hunan, China (Z.W., G.W., T.L., B.X., Y.P., H.S., Y.Z., Y.-S.Z.); Department of Pharmacy, Third Xiangya Hospital, Central South University, Changsha, Hunan, China (Q.P., G.Y.); Department of Biochemistry and Molecular Biology, Hunan University of Chinese Medicine, Changsha, Hunan, China (L.C.); and Beijing Chao-Yang Hospital, Capital Medical University, Beijing, China (Z.W.)
Yuan-Shan Zhu
Department of Clinical Pharmacology of Xiangya Hospital, Central South University, Changsha, Hunan, China (Z.W., G.W., T.L., B.X., Y.P., H.S., Y.Z., Y.-S.Z.); Institute of Clinical Pharmacology, Central South University, Changsha, Hunan, China (Z.W., G.W., T.L., B.X., Y.P., H.S., Y.Z., Y.-S.Z.); Hunan Key Laboratory of Pharmacogenetics, Changsha, Hunan, China (Z.W., G.W., T.L., B.X., Y.P., H.S., Y.Z., Y.-S.Z.); Department of Pharmacy, Third Xiangya Hospital, Central South University, Changsha, Hunan, China (Q.P., G.Y.); Department of Biochemistry and Molecular Biology, Hunan University of Chinese Medicine, Changsha, Hunan, China (L.C.); and Beijing Chao-Yang Hospital, Capital Medical University, Beijing, China (Z.W.)
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In this issue
Research ArticleMetabolism, Transport, and Pharmacogenomics
ABCG2 Haplotypes on Rosuvastatin Pharmacokinetics
Zirui Wan, Guo Wang, Tailin Li, Biaobo Xu, Qi Pei, Yan Peng, Hong Sun, Lijuan Cheng, Ying Zeng, Guoping Yang and Yuan-Shan Zhu
Journal of Pharmacology and Experimental Therapeutics September 1, 2015, 354 (3) 310-315; DOI: https://doi.org/10.1124/jpet.115.225045
Research ArticleMetabolism, Transport, and Pharmacogenomics
ABCG2 Haplotypes on Rosuvastatin Pharmacokinetics
Zirui Wan, Guo Wang, Tailin Li, Biaobo Xu, Qi Pei, Yan Peng, Hong Sun, Lijuan Cheng, Ying Zeng, Guoping Yang and Yuan-Shan Zhu
Journal of Pharmacology and Experimental Therapeutics September 1, 2015, 354 (3) 310-315; DOI: https://doi.org/10.1124/jpet.115.225045
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