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Research ArticleDrug Discovery and Translational Medicine

Humanized Thymidine Kinase–NOG Mice Can Be Used to Identify Drugs That Cause Animal-Specific Hepatotoxicity: A Case Study with Furosemide

Dan Xu, Sara A. Michie, Ming Zheng, Saori Takeda, Manhong Wu and Gary Peltz
Journal of Pharmacology and Experimental Therapeutics July 2015, 354 (1) 73-78; DOI: https://doi.org/10.1124/jpet.115.224493

Article Information

vol. 354 no. 1 73-78
DOI 
https://doi.org/10.1124/jpet.115.224493
PubMed 
25962391
Published By 
American Society for Pharmacology and Experimental Therapeutics
Print ISSN 
0022-3565
Online ISSN 
1521-0103
History 
  • Received March 18, 2015
  • Accepted May 8, 2015
  • Published online June 1, 2015.

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Copyright & Usage 
Copyright © 2015 by The American Society for Pharmacology and Experimental Therapeutics

Author Information

  1. Dan Xu,
  2. Sara A. Michie,
  3. Ming Zheng,
  4. Saori Takeda,
  5. Manhong Wu, and
  6. Gary Peltz
  1. Department of Anesthesia, Stanford University School of Medicine, Stanford, California (D.X., M.Z., M.W., G.P.); Department of Pathology, Stanford University, Stanford, California (S.A.M.); and In Vivo Sciences International, Sunnyvale, California (S.T.)
  1. Address correspondence to:
    Gary Peltz, Stanford University Medical School 300 Pasteur Drive Stanford CA 94305. E-mail: gpeltz{at}stanford.edu
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Research ArticleDrug Discovery and Translational Medicine

Rescuing Drugs for Human Use

Dan Xu, Sara A. Michie, Ming Zheng, Saori Takeda, Manhong Wu and Gary Peltz
Journal of Pharmacology and Experimental Therapeutics July 1, 2015, 354 (1) 73-78; DOI: https://doi.org/10.1124/jpet.115.224493
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