Research ArticleDrug Discovery and Translational Medicine
A Novel Partial Agonist of Peroxisome Proliferator-Activated Receptor γ with Excellent Effect on Insulin Resistance and Type 2 Diabetes
Hui-juan Liu, Cheng-yu Zhang, Fei Song, Ting Xiao, Jing Meng, Qiang Zhang, Cai-li Liang, Shan Li, Jing Wang, Bo Zhang, Yan-rong Liu, Tao Sun and Hong-gang Zhou
Journal of Pharmacology and Experimental Therapeutics June 2015, 353 (3) 573-581; DOI: https://doi.org/10.1124/jpet.115.223107
Hui-juan Liu
Tianjin Key Laboratory of Molecular Drug Research, Tianjin International Joint Academy of Biomedicine, Tianjin, People’s Republic of China (H.L., C.Z., F.S., T.X., J.M., Q.Z., C.L., S.L., J.W., B.Z., Y.L.); and The State Key Laboratory of Medicinal Chemical Biology, College of Pharmacy, Nankai University, Tianjin, People’s Republic of China (T.S., H.Z.).
Cheng-yu Zhang
Tianjin Key Laboratory of Molecular Drug Research, Tianjin International Joint Academy of Biomedicine, Tianjin, People’s Republic of China (H.L., C.Z., F.S., T.X., J.M., Q.Z., C.L., S.L., J.W., B.Z., Y.L.); and The State Key Laboratory of Medicinal Chemical Biology, College of Pharmacy, Nankai University, Tianjin, People’s Republic of China (T.S., H.Z.).
Fei Song
Tianjin Key Laboratory of Molecular Drug Research, Tianjin International Joint Academy of Biomedicine, Tianjin, People’s Republic of China (H.L., C.Z., F.S., T.X., J.M., Q.Z., C.L., S.L., J.W., B.Z., Y.L.); and The State Key Laboratory of Medicinal Chemical Biology, College of Pharmacy, Nankai University, Tianjin, People’s Republic of China (T.S., H.Z.).
Ting Xiao
Tianjin Key Laboratory of Molecular Drug Research, Tianjin International Joint Academy of Biomedicine, Tianjin, People’s Republic of China (H.L., C.Z., F.S., T.X., J.M., Q.Z., C.L., S.L., J.W., B.Z., Y.L.); and The State Key Laboratory of Medicinal Chemical Biology, College of Pharmacy, Nankai University, Tianjin, People’s Republic of China (T.S., H.Z.).
Jing Meng
Tianjin Key Laboratory of Molecular Drug Research, Tianjin International Joint Academy of Biomedicine, Tianjin, People’s Republic of China (H.L., C.Z., F.S., T.X., J.M., Q.Z., C.L., S.L., J.W., B.Z., Y.L.); and The State Key Laboratory of Medicinal Chemical Biology, College of Pharmacy, Nankai University, Tianjin, People’s Republic of China (T.S., H.Z.).
Qiang Zhang
Tianjin Key Laboratory of Molecular Drug Research, Tianjin International Joint Academy of Biomedicine, Tianjin, People’s Republic of China (H.L., C.Z., F.S., T.X., J.M., Q.Z., C.L., S.L., J.W., B.Z., Y.L.); and The State Key Laboratory of Medicinal Chemical Biology, College of Pharmacy, Nankai University, Tianjin, People’s Republic of China (T.S., H.Z.).
Cai-li Liang
Tianjin Key Laboratory of Molecular Drug Research, Tianjin International Joint Academy of Biomedicine, Tianjin, People’s Republic of China (H.L., C.Z., F.S., T.X., J.M., Q.Z., C.L., S.L., J.W., B.Z., Y.L.); and The State Key Laboratory of Medicinal Chemical Biology, College of Pharmacy, Nankai University, Tianjin, People’s Republic of China (T.S., H.Z.).
Shan Li
Tianjin Key Laboratory of Molecular Drug Research, Tianjin International Joint Academy of Biomedicine, Tianjin, People’s Republic of China (H.L., C.Z., F.S., T.X., J.M., Q.Z., C.L., S.L., J.W., B.Z., Y.L.); and The State Key Laboratory of Medicinal Chemical Biology, College of Pharmacy, Nankai University, Tianjin, People’s Republic of China (T.S., H.Z.).
Jing Wang
Tianjin Key Laboratory of Molecular Drug Research, Tianjin International Joint Academy of Biomedicine, Tianjin, People’s Republic of China (H.L., C.Z., F.S., T.X., J.M., Q.Z., C.L., S.L., J.W., B.Z., Y.L.); and The State Key Laboratory of Medicinal Chemical Biology, College of Pharmacy, Nankai University, Tianjin, People’s Republic of China (T.S., H.Z.).
Bo Zhang
Tianjin Key Laboratory of Molecular Drug Research, Tianjin International Joint Academy of Biomedicine, Tianjin, People’s Republic of China (H.L., C.Z., F.S., T.X., J.M., Q.Z., C.L., S.L., J.W., B.Z., Y.L.); and The State Key Laboratory of Medicinal Chemical Biology, College of Pharmacy, Nankai University, Tianjin, People’s Republic of China (T.S., H.Z.).
Yan-rong Liu
Tianjin Key Laboratory of Molecular Drug Research, Tianjin International Joint Academy of Biomedicine, Tianjin, People’s Republic of China (H.L., C.Z., F.S., T.X., J.M., Q.Z., C.L., S.L., J.W., B.Z., Y.L.); and The State Key Laboratory of Medicinal Chemical Biology, College of Pharmacy, Nankai University, Tianjin, People’s Republic of China (T.S., H.Z.).
Tao Sun
Tianjin Key Laboratory of Molecular Drug Research, Tianjin International Joint Academy of Biomedicine, Tianjin, People’s Republic of China (H.L., C.Z., F.S., T.X., J.M., Q.Z., C.L., S.L., J.W., B.Z., Y.L.); and The State Key Laboratory of Medicinal Chemical Biology, College of Pharmacy, Nankai University, Tianjin, People’s Republic of China (T.S., H.Z.).
Hong-gang Zhou
Tianjin Key Laboratory of Molecular Drug Research, Tianjin International Joint Academy of Biomedicine, Tianjin, People’s Republic of China (H.L., C.Z., F.S., T.X., J.M., Q.Z., C.L., S.L., J.W., B.Z., Y.L.); and The State Key Laboratory of Medicinal Chemical Biology, College of Pharmacy, Nankai University, Tianjin, People’s Republic of China (T.S., H.Z.).
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Research ArticleDrug Discovery and Translational Medicine
A Novel Partial Agonist of PPARγ
Hui-juan Liu, Cheng-yu Zhang, Fei Song, Ting Xiao, Jing Meng, Qiang Zhang, Cai-li Liang, Shan Li, Jing Wang, Bo Zhang, Yan-rong Liu, Tao Sun and Hong-gang Zhou
Journal of Pharmacology and Experimental Therapeutics June 1, 2015, 353 (3) 573-581; DOI: https://doi.org/10.1124/jpet.115.223107
Research ArticleDrug Discovery and Translational Medicine
A Novel Partial Agonist of PPARγ
Hui-juan Liu, Cheng-yu Zhang, Fei Song, Ting Xiao, Jing Meng, Qiang Zhang, Cai-li Liang, Shan Li, Jing Wang, Bo Zhang, Yan-rong Liu, Tao Sun and Hong-gang Zhou
Journal of Pharmacology and Experimental Therapeutics June 1, 2015, 353 (3) 573-581; DOI: https://doi.org/10.1124/jpet.115.223107
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