Research ArticleDrug Discovery and Translational Medicine
Differential Impact of Amino Acid Substitutions on Critical Residues of the Human Glucagon-Like Peptide-1 Receptor Involved in Peptide Activity and Small-Molecule Allostery
Cassandra Koole, Denise Wootten, John Simms, Laurence J. Miller, Arthur Christopoulos and Patrick M. Sexton
Journal of Pharmacology and Experimental Therapeutics April 2015, 353 (1) 52-63; DOI: https://doi.org/10.1124/jpet.114.220913
Cassandra Koole
Drug Discovery Biology Laboratory, Monash Institute of Pharmaceutical Sciences and Department of Pharmacology, Monash University, Parkville, Victoria, Australia (C.K., D.W., J.S., A.C., P.M.S.); and Department of Molecular Pharmacology and Experimental Therapeutics, Mayo Clinic, Scottsdale, Arizona (L.J.M.)
Denise Wootten
Drug Discovery Biology Laboratory, Monash Institute of Pharmaceutical Sciences and Department of Pharmacology, Monash University, Parkville, Victoria, Australia (C.K., D.W., J.S., A.C., P.M.S.); and Department of Molecular Pharmacology and Experimental Therapeutics, Mayo Clinic, Scottsdale, Arizona (L.J.M.)
John Simms
Drug Discovery Biology Laboratory, Monash Institute of Pharmaceutical Sciences and Department of Pharmacology, Monash University, Parkville, Victoria, Australia (C.K., D.W., J.S., A.C., P.M.S.); and Department of Molecular Pharmacology and Experimental Therapeutics, Mayo Clinic, Scottsdale, Arizona (L.J.M.)
Laurence J. Miller
Drug Discovery Biology Laboratory, Monash Institute of Pharmaceutical Sciences and Department of Pharmacology, Monash University, Parkville, Victoria, Australia (C.K., D.W., J.S., A.C., P.M.S.); and Department of Molecular Pharmacology and Experimental Therapeutics, Mayo Clinic, Scottsdale, Arizona (L.J.M.)
Arthur Christopoulos
Drug Discovery Biology Laboratory, Monash Institute of Pharmaceutical Sciences and Department of Pharmacology, Monash University, Parkville, Victoria, Australia (C.K., D.W., J.S., A.C., P.M.S.); and Department of Molecular Pharmacology and Experimental Therapeutics, Mayo Clinic, Scottsdale, Arizona (L.J.M.)
Patrick M. Sexton
Drug Discovery Biology Laboratory, Monash Institute of Pharmaceutical Sciences and Department of Pharmacology, Monash University, Parkville, Victoria, Australia (C.K., D.W., J.S., A.C., P.M.S.); and Department of Molecular Pharmacology and Experimental Therapeutics, Mayo Clinic, Scottsdale, Arizona (L.J.M.)
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Research ArticleDrug Discovery and Translational Medicine
GLP-1R Residues Important for Activity and Modulation
Cassandra Koole, Denise Wootten, John Simms, Laurence J. Miller, Arthur Christopoulos and Patrick M. Sexton
Journal of Pharmacology and Experimental Therapeutics April 1, 2015, 353 (1) 52-63; DOI: https://doi.org/10.1124/jpet.114.220913
Research ArticleDrug Discovery and Translational Medicine
GLP-1R Residues Important for Activity and Modulation
Cassandra Koole, Denise Wootten, John Simms, Laurence J. Miller, Arthur Christopoulos and Patrick M. Sexton
Journal of Pharmacology and Experimental Therapeutics April 1, 2015, 353 (1) 52-63; DOI: https://doi.org/10.1124/jpet.114.220913
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