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Research ArticleDrug Discovery and Translational Medicine

Pharmacology of a Central Nervous System Delivered 2′-O-Methoxyethyl–Modified Survival of Motor Neuron Splicing Oligonucleotide in Mice and Nonhuman Primates

Frank Rigo, Seung J. Chun, Daniel A. Norris, Gene Hung, Sam Lee, John Matson, Robert A. Fey, Hans Gaus, Yimin Hua, John S. Grundy, Adrian R. Krainer, Scott P. Henry and C. Frank Bennett
Journal of Pharmacology and Experimental Therapeutics July 2014, 350 (1) 46-55; DOI: https://doi.org/10.1124/jpet.113.212407

Article Information

vol. 350 no. 1 46-55
DOI 
https://doi.org/10.1124/jpet.113.212407
PubMed 
24784568
Published By 
American Society for Pharmacology and Experimental Therapeutics
Print ISSN 
0022-3565
Online ISSN 
1521-0103
History 
  • Received December 20, 2013
  • Accepted April 28, 2014
  • Published online June 2, 2014.

Article Versions

Copyright & Usage 
Copyright © 2014 by The American Society for Pharmacology and Experimental Therapeutics

Author Information

  1. Frank Rigo,
  2. Seung J. Chun,
  3. Daniel A. Norris,
  4. Gene Hung,
  5. Sam Lee,
  6. John Matson,
  7. Robert A. Fey,
  8. Hans Gaus,
  9. Yimin Hua,
  10. John S. Grundy,
  11. Adrian R. Krainer,
  12. Scott P. Henry, and
  13. C. Frank Bennett
  1. Isis Pharmaceuticals, Carlsbad, California (F.R., S.J.C., D.A.N., G.H., S.L., J.M., R.A.F., H.G., J.S.G., S.P.H., C.F.B.); and Cold Spring Harbor Laboratory, Cold Spring Harbor, New York (Y.H., A.R.K.)
  1. Address correspondence to:
    Frank Rigo, 2855 Gazelle Court, Carlsbad, CA 92010. E-mail: frigo{at}isisph.com
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Research ArticleDrug Discovery and Translational Medicine

Pharmacology of ISIS 396443 in the Central Nervous System

Frank Rigo, Seung J. Chun, Daniel A. Norris, Gene Hung, Sam Lee, John Matson, Robert A. Fey, Hans Gaus, Yimin Hua, John S. Grundy, Adrian R. Krainer, Scott P. Henry and C. Frank Bennett
Journal of Pharmacology and Experimental Therapeutics July 1, 2014, 350 (1) 46-55; DOI: https://doi.org/10.1124/jpet.113.212407
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