Research ArticleNeuropharmacology
Positive Allosteric Modulation of AMPA Receptors from Efficacy to Toxicity: The Interspecies Exposure-Response Continuum of the Novel Potentiator PF-4778574
Christopher L. Shaffer, Raymond S. Hurst, Renato J. Scialis, Sarah M. Osgood, Dianne K. Bryce, William E. Hoffmann, John T. Lazzaro, Ashley N. Hanks, Susan Lotarski, Mark L. Weber, JianHua Liu, Frank S. Menniti, Christopher J. Schmidt and Mihály Hajós
Journal of Pharmacology and Experimental Therapeutics October 2013, 347 (1) 212-224; DOI: https://doi.org/10.1124/jpet.113.204735
Christopher L. Shaffer
Department of Pharmacokinetics, Pharmacodynamics and Metabolism (C.L.S., R.J.S., S.M.O., J.L.) and the Neuroscience Research Unit (R.S.H., D.K.B., W.E.H., J.T.L., A.N.H., S.L., M.L.W., F.S.M., C.J.S., M.H.), Worldwide Research and Development, Groton Laboratories, Pfizer Inc., Groton, Connecticut
Raymond S. Hurst
Department of Pharmacokinetics, Pharmacodynamics and Metabolism (C.L.S., R.J.S., S.M.O., J.L.) and the Neuroscience Research Unit (R.S.H., D.K.B., W.E.H., J.T.L., A.N.H., S.L., M.L.W., F.S.M., C.J.S., M.H.), Worldwide Research and Development, Groton Laboratories, Pfizer Inc., Groton, Connecticut
Renato J. Scialis
Department of Pharmacokinetics, Pharmacodynamics and Metabolism (C.L.S., R.J.S., S.M.O., J.L.) and the Neuroscience Research Unit (R.S.H., D.K.B., W.E.H., J.T.L., A.N.H., S.L., M.L.W., F.S.M., C.J.S., M.H.), Worldwide Research and Development, Groton Laboratories, Pfizer Inc., Groton, Connecticut
Sarah M. Osgood
Department of Pharmacokinetics, Pharmacodynamics and Metabolism (C.L.S., R.J.S., S.M.O., J.L.) and the Neuroscience Research Unit (R.S.H., D.K.B., W.E.H., J.T.L., A.N.H., S.L., M.L.W., F.S.M., C.J.S., M.H.), Worldwide Research and Development, Groton Laboratories, Pfizer Inc., Groton, Connecticut
Dianne K. Bryce
Department of Pharmacokinetics, Pharmacodynamics and Metabolism (C.L.S., R.J.S., S.M.O., J.L.) and the Neuroscience Research Unit (R.S.H., D.K.B., W.E.H., J.T.L., A.N.H., S.L., M.L.W., F.S.M., C.J.S., M.H.), Worldwide Research and Development, Groton Laboratories, Pfizer Inc., Groton, Connecticut
William E. Hoffmann
Department of Pharmacokinetics, Pharmacodynamics and Metabolism (C.L.S., R.J.S., S.M.O., J.L.) and the Neuroscience Research Unit (R.S.H., D.K.B., W.E.H., J.T.L., A.N.H., S.L., M.L.W., F.S.M., C.J.S., M.H.), Worldwide Research and Development, Groton Laboratories, Pfizer Inc., Groton, Connecticut
John T. Lazzaro
Department of Pharmacokinetics, Pharmacodynamics and Metabolism (C.L.S., R.J.S., S.M.O., J.L.) and the Neuroscience Research Unit (R.S.H., D.K.B., W.E.H., J.T.L., A.N.H., S.L., M.L.W., F.S.M., C.J.S., M.H.), Worldwide Research and Development, Groton Laboratories, Pfizer Inc., Groton, Connecticut
Ashley N. Hanks
Department of Pharmacokinetics, Pharmacodynamics and Metabolism (C.L.S., R.J.S., S.M.O., J.L.) and the Neuroscience Research Unit (R.S.H., D.K.B., W.E.H., J.T.L., A.N.H., S.L., M.L.W., F.S.M., C.J.S., M.H.), Worldwide Research and Development, Groton Laboratories, Pfizer Inc., Groton, Connecticut
Susan Lotarski
Department of Pharmacokinetics, Pharmacodynamics and Metabolism (C.L.S., R.J.S., S.M.O., J.L.) and the Neuroscience Research Unit (R.S.H., D.K.B., W.E.H., J.T.L., A.N.H., S.L., M.L.W., F.S.M., C.J.S., M.H.), Worldwide Research and Development, Groton Laboratories, Pfizer Inc., Groton, Connecticut
Mark L. Weber
Department of Pharmacokinetics, Pharmacodynamics and Metabolism (C.L.S., R.J.S., S.M.O., J.L.) and the Neuroscience Research Unit (R.S.H., D.K.B., W.E.H., J.T.L., A.N.H., S.L., M.L.W., F.S.M., C.J.S., M.H.), Worldwide Research and Development, Groton Laboratories, Pfizer Inc., Groton, Connecticut
JianHua Liu
Department of Pharmacokinetics, Pharmacodynamics and Metabolism (C.L.S., R.J.S., S.M.O., J.L.) and the Neuroscience Research Unit (R.S.H., D.K.B., W.E.H., J.T.L., A.N.H., S.L., M.L.W., F.S.M., C.J.S., M.H.), Worldwide Research and Development, Groton Laboratories, Pfizer Inc., Groton, Connecticut
Frank S. Menniti
Department of Pharmacokinetics, Pharmacodynamics and Metabolism (C.L.S., R.J.S., S.M.O., J.L.) and the Neuroscience Research Unit (R.S.H., D.K.B., W.E.H., J.T.L., A.N.H., S.L., M.L.W., F.S.M., C.J.S., M.H.), Worldwide Research and Development, Groton Laboratories, Pfizer Inc., Groton, Connecticut
Christopher J. Schmidt
Department of Pharmacokinetics, Pharmacodynamics and Metabolism (C.L.S., R.J.S., S.M.O., J.L.) and the Neuroscience Research Unit (R.S.H., D.K.B., W.E.H., J.T.L., A.N.H., S.L., M.L.W., F.S.M., C.J.S., M.H.), Worldwide Research and Development, Groton Laboratories, Pfizer Inc., Groton, Connecticut
Mihály Hajós
Department of Pharmacokinetics, Pharmacodynamics and Metabolism (C.L.S., R.J.S., S.M.O., J.L.) and the Neuroscience Research Unit (R.S.H., D.K.B., W.E.H., J.T.L., A.N.H., S.L., M.L.W., F.S.M., C.J.S., M.H.), Worldwide Research and Development, Groton Laboratories, Pfizer Inc., Groton, Connecticut
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In this issue
Research ArticleNeuropharmacology
Exposure-Response Continuum of an AMPAR Potentiator
Christopher L. Shaffer, Raymond S. Hurst, Renato J. Scialis, Sarah M. Osgood, Dianne K. Bryce, William E. Hoffmann, John T. Lazzaro, Ashley N. Hanks, Susan Lotarski, Mark L. Weber, JianHua Liu, Frank S. Menniti, Christopher J. Schmidt and Mihály Hajós
Journal of Pharmacology and Experimental Therapeutics October 1, 2013, 347 (1) 212-224; DOI: https://doi.org/10.1124/jpet.113.204735
Research ArticleNeuropharmacology
Exposure-Response Continuum of an AMPAR Potentiator
Christopher L. Shaffer, Raymond S. Hurst, Renato J. Scialis, Sarah M. Osgood, Dianne K. Bryce, William E. Hoffmann, John T. Lazzaro, Ashley N. Hanks, Susan Lotarski, Mark L. Weber, JianHua Liu, Frank S. Menniti, Christopher J. Schmidt and Mihály Hajós
Journal of Pharmacology and Experimental Therapeutics October 1, 2013, 347 (1) 212-224; DOI: https://doi.org/10.1124/jpet.113.204735
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