Journal of Pharmacology and Experimental Therapeutics: 344 (1)

January 01, 2013; Volume 344,Issue 1

Highlighted Papers

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Phosphoinositide-Dependent Kinase-1 Can Contribute to Hypertension
Journal of Pharmacology and Experimental Therapeutics January 2013, 344 (1) 1; DOI: https://doi.org/10.1124/jpet.112.0113HIa
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Screening for the Detection of G Protein-Coupled Receptor Heteromer Signaling
Journal of Pharmacology and Experimental Therapeutics January 2013, 344 (1) 1; DOI: https://doi.org/10.1124/jpet.112.0113HIb
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A Cationic Analog of Ceramide Induces Pancreatic Cancer Cell Death
Journal of Pharmacology and Experimental Therapeutics January 2013, 344 (1) 1; DOI: https://doi.org/10.1124/jpet.112.0113HIc
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Hydrophobic Amino Acids in the Hinge Region of the 5A Apolipoprotein Mimetic Peptide Are Essential for Promoting Cholesterol Efflux
Journal of Pharmacology and Experimental Therapeutics January 2013, 344 (1) 1; DOI: https://doi.org/10.1124/jpet.112.0113HI

Perspectives in Pharmacology

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Alkaline Phosphatase as a Treatment of Sepsis-Associated Acute Kidney Injury
Esther Peters, Andrea van Elsas, Suzanne Heemskerk, Luigi Jonk, Johannes van der Hoeven, Jacques Arend, Rosalinde Masereeuw and Peter Pickkers

Journal of Pharmacology and Experimental Therapeutics January 2013, 344 (1) 2-7; DOI: https://doi.org/10.1124/jpet.112.198226

Behavioral Pharmacology

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Diuretic Effects of Cannabinoids
Carol A. Paronis, Ganesh A. Thakur, Shama Bajaj, Spyros P. Nikas, V. Kiran Vemuri, Alexandros Makriyannis and Jack Bergman

Journal of Pharmacology and Experimental Therapeutics January 2013, 344 (1) 8-14; DOI: https://doi.org/10.1124/jpet.112.199331

Cardiovascular

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Endothelial Nitric Oxide Synthase-Independent Release of Nitric Oxide in the Aorta of the Spontaneously Hypertensive Rat
Yingzi Zhao, Paul M. Vanhoutte and Susan W. S. Leung

Journal of Pharmacology and Experimental Therapeutics January 2013, 344 (1) 15-22; DOI: https://doi.org/10.1124/jpet.112.198721
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A Novel, Potent, and Selective Inhibitor of Cardiac Late Sodium Current Suppresses Experimental Arrhythmias
Luiz Belardinelli, Gongxin Liu, Cathy Smith-Maxwell, Wei-Qun Wang, Nesrine El-Bizri, Ryoko Hirakawa, Serge Karpinski, Cindy Hong Li, Lufei Hu, Xiao-Jun Li, William Crumb, Lin Wu, Dmitry Koltun, Jeff Zablocki, Lina Yao, Arvinder K. Dhalla, Sridharan Rajamani and John C. Shryock

Journal of Pharmacology and Experimental Therapeutics January 2013, 344 (1) 23-32; DOI: https://doi.org/10.1124/jpet.112.198887
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A TRPC3 Blocker, Ethyl-1-(4-(2,3,3-Trichloroacrylamide)Phenyl)-5-(Trifluoromethyl)-1H-Pyrazole-4-Carboxylate (Pyr3), Prevents Stent-Induced Arterial Remodeling
Sarah Koenig, Michaela Schernthaner, Heinrich Maechler, C. Oliver Kappe, Toma N. Glasnov, Gerald Hoefler, Marlen Braune, Eric Wittchow and Klaus Groschner

Journal of Pharmacology and Experimental Therapeutics January 2013, 344 (1) 33-40; DOI: https://doi.org/10.1124/jpet.112.196832
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Anti-Inflammatory Functions of Apolipoprotein A-I and High-Density Lipoprotein Are Preserved in Trimeric Apolipoprotein A-I
Andrew J. Murphy, Anh Hoang, Andrea Aprico, Dmitri Sviridov and Jaye Chin-Dusting

Journal of Pharmacology and Experimental Therapeutics January 2013, 344 (1) 41-49; DOI: https://doi.org/10.1124/jpet.112.199257
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Hydrophobic Amino Acids in the Hinge Region of the 5A Apolipoprotein Mimetic Peptide are Essential for Promoting Cholesterol Efflux by the ABCA1 Transporter
Denis O. Sviridov, Alexander M. Andrianov, Ivan V. Anishchenko, John A. Stonik, Marcelo J. A. Amar, Scott Turner and Alan T. Remaley

Journal of Pharmacology and Experimental Therapeutics January 2013, 344 (1) 50-58; DOI: https://doi.org/10.1124/jpet.112.198143
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INO-8875, a Highly Selective A₁ Adenosine Receptor Agonist: Evaluation of Chronotropic, Dromotropic, and Hemodynamic Effects in Rats
Michal Mor, Aryeh Shalev, Shani Dror, Oleg Pikovsky, Ofer Beharier, Arie Moran, Amos Katz and Yoram Etzion

Journal of Pharmacology and Experimental Therapeutics January 2013, 344 (1) 59-67; DOI: https://doi.org/10.1124/jpet.112.200873
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Phosphoinositide-Dependent Kinase-1 and Protein Kinase Cδ Contribute to Endothelin-1 Constriction and Elevated Blood Pressure in Intermittent Hypoxia
Bradley R. Webster, Jessica M. Osmond, Daniel A. Paredes, Xavier A. DeLeon, Olan Jackson-Weaver, Benjimen R. Walker and Nancy L. Kanagy

Journal of Pharmacology and Experimental Therapeutics January 2013, 344 (1) 68-76; DOI: https://doi.org/10.1124/jpet.112.195412
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Cytosolic Ca²⁺–Induced Apoptosis in Rat Cardiomyocytes via Mitochondrial NO-cGMP-Protein Kinase G Pathway
Kazuhiko Seya, Kyoichi Ono, Susumu Fujisawa, Ken Okumura, Shigeru Motomura and Ken-Ichi Furukawa

Journal of Pharmacology and Experimental Therapeutics January 2013, 344 (1) 77-84; DOI: https://doi.org/10.1124/jpet.112.198176

Cellular and Molecular

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Interruption of the Ionic Lock in the Bradykinin B₂ Receptor Results in Constitutive Internalization and Turns Several Antagonists into Strong Agonists
Jasmin Leschner, Goeran Wennerberg, Jens Feierler, Marcel Bermudez, Benjamin Welte, Irina Kalatskaya, Gerhard Wolber and Alexander Faussner

Journal of Pharmacology and Experimental Therapeutics January 2013, 344 (1) 85-95; DOI: https://doi.org/10.1124/jpet.112.199190
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C-Type Natriuretic Peptide Protects the Retinal Pigment Epithelium against Advanced Glycation End Product–Induced Barrier Dysfunction
Mohammad Dahrouj, Oday Alsarraf, Yueying Liu, Craig E. Crosson and Zsolt Ablonczy

Journal of Pharmacology and Experimental Therapeutics January 2013, 344 (1) 96-102; DOI: https://doi.org/10.1124/jpet.112.199307

Chemotherapy, Antibiotics, and Gene Therapy

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Systems Pharmacological Analysis of Paclitaxel-Mediated Tumor Priming That Enhances Nanocarrier Deposition and Efficacy
Sihem Ait-Oudhia, Robert M. Straubinger and Donald E. Mager

Journal of Pharmacology and Experimental Therapeutics January 2013, 344 (1) 103-112; DOI: https://doi.org/10.1124/jpet.112.199109

Drug Discovery and Translational Medicine

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Functional and Structural Interaction of (−)-Reboxetine with the Human α4β2 Nicotinic Acetylcholine Receptor
Hugo R. Arias, Nikolai B. Fedorov, Lisa C. Benson, Patrick M. Lippiello, Greg J. Gatto, Dominik Feuerbach and Marcelo O. Ortells

Journal of Pharmacology and Experimental Therapeutics January 2013, 344 (1) 113-123; DOI: https://doi.org/10.1124/jpet.112.197905
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Differential Cell-Protective Function of Two Resveratrol (Trans-3,5,4′-trihydroxystilbene) Glucosides against Oxidative Stress
Ryusuke Hosoda, Atsushi Kuno, Yusuke S. Hori, Katsuki Ohtani, Nobutaka Wakamiya, Azusa Oohiro, Hiroki Hamada and Yoshiyuki Horio

Journal of Pharmacology and Experimental Therapeutics January 2013, 344 (1) 124-132; DOI: https://doi.org/10.1124/jpet.112.198937
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Efficacy of the GluK1/AMPA Receptor Antagonist LY293558 against Seizures and Neuropathology in a Soman-Exposure Model without Pretreatment and its Pharmacokinetics after Intramuscular Administration
James P. Apland, Vassiliki Aroniadou-Anderjaska, Taiza H. Figueiredo, Carol E. Green, Robert Swezey, Chun Yang, Felicia Qashu and Maria F. M. Braga

Journal of Pharmacology and Experimental Therapeutics January 2013, 344 (1) 133-140; DOI: https://doi.org/10.1124/jpet.112.198689
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Evaluation of Metabolically Stabilized Angiotensin IV Analogs as Procognitive/Antidementia Agents
Alene T. McCoy, Caroline C. Benoist, John W. Wright, Leen H. Kawas, Jyote M. Bule-Ghogare, Mingyan Zhu, Suzanne M. Appleyard, Gary A. Wayman and Joseph W. Harding

Journal of Pharmacology and Experimental Therapeutics January 2013, 344 (1) 141-154; DOI: https://doi.org/10.1124/jpet.112.199497
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In Vitro Evaluation of Guanidine Analogs as Sigma Receptor Ligands for Potential Anti-Stroke Therapeutics
Adam A. Behensky, Michelle Cortes-Salva, Michael J. Seminerio, Rae R. Matsumoto, Jon C. Antilla and Javier Cuevas

Journal of Pharmacology and Experimental Therapeutics January 2013, 344 (1) 155-166; DOI: https://doi.org/10.1124/jpet.112.199513
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LCL124, a Cationic Analog of Ceramide, Selectively Induces Pancreatic Cancer Cell Death by Accumulating in Mitochondria
Thomas H. Beckham, Ping Lu, Elizabeth E. Jones, Tucker Marrison, Clayton S. Lewis, Joseph C. Cheng, Venkat K. Ramshesh, Gyda Beeson, Craig C. Beeson, Richard R. Drake, Alicja Bielawska, Jacek Bielawski, Zdzislaw M. Szulc, Besim Ogretmen, James S. Norris and Xiang Liu

Journal of Pharmacology and Experimental Therapeutics January 2013, 344 (1) 167-178; DOI: https://doi.org/10.1124/jpet.112.199216
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Novel Screening Assay for the Selective Detection of G-Protein-Coupled Receptor Heteromer Signaling
Richard M. van Rijn, Jessica H. Harvey, Daniela I. Brissett, Julia N. DeFriel and Jennifer L. Whistler

Journal of Pharmacology and Experimental Therapeutics January 2013, 344 (1) 179-188; DOI: https://doi.org/10.1124/jpet.112.198655

Gastrointestinal, Hepatic, Pulmonary, and Renal

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Cyclooxygenase (COX)-1 and COX-2 Both Play an Important Role in the Protection of the Duodenal Mucosa in Cats
Hiroshi Satoh, Kikuko Amagase, Satomi Ebara, Yasutada Akiba and Koji Takeuchi

Journal of Pharmacology and Experimental Therapeutics January 2013, 344 (1) 189-195; DOI: https://doi.org/10.1124/jpet.112.199182
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Pharmacologic Properties, Metabolism, and Disposition of Linaclotide, a Novel Therapeutic Peptide Approved for the Treatment of Irritable Bowel Syndrome with Constipation and Chronic Idiopathic Constipation
Robert W. Busby, Marco M. Kessler, Wilmin P. Bartolini, Alexander P. Bryant, Gerhard Hannig, Carolyn S. Higgins, Robert M. Solinga, Jenny V. Tobin, James D. Wakefield, Caroline B. Kurtz and Mark G. Currie

Journal of Pharmacology and Experimental Therapeutics January 2013, 344 (1) 196-206; DOI: https://doi.org/10.1124/jpet.112.199430
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Novel Insights on the Effect of Nicotine in a Murine Colitis Model
Shakir D. AlSharari, Hamid I. Akbarali, Rehab A. Abdullah, Omer Shahab, Wimolnut Auttachoat, Gabriela A. Ferreira, Kimber L. White, Aron H. Lichtman, Guy A. Cabral and M. Imad Damaj

Journal of Pharmacology and Experimental Therapeutics January 2013, 344 (1) 207-217; DOI: https://doi.org/10.1124/jpet.112.198796
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In Vitro Pharmacological Characterization of Vilanterol, a Novel Long-Acting β₂-Adrenoceptor Agonist with 24-Hour Duration of Action
Robert J. Slack, Victoria J. Barrett, Valerie S. Morrison, Richard G. Sturton, Amanda J. Emmons, Alison J. Ford and Richard G. Knowles

Journal of Pharmacology and Experimental Therapeutics January 2013, 344 (1) 218-230; DOI: https://doi.org/10.1124/jpet.112.198481

Inflammation, Immunopharmacology, and Asthma

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Prasugrel Metabolites Inhibit Neutrophil Functions
Elisabetta Liverani, Mario C. Rico, Analia E. Garcia, Laurie E. Kilpatrick and Satya P. Kunapuli

Journal of Pharmacology and Experimental Therapeutics January 2013, 344 (1) 231-243; DOI: https://doi.org/10.1124/jpet.112.195883

Metabolism, Transport, and Pharmacogenomics

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Regulation of Hepatic Phase II Metabolism in Pregnant Mice
Xia Wen, Ajay C. Donepudi, Paul E. Thomas, Angela L. Slitt, Roberta S. King and Lauren M. Aleksunes

Journal of Pharmacology and Experimental Therapeutics January 2013, 344 (1) 244-252; DOI: https://doi.org/10.1124/jpet.112.199034

Neuropharmacology

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Reversal of Dopamine D2 Agonist-Induced Inhibition of Ventral Tegmental Area Neurons by Gq-Linked Neurotransmitters Is Dependent on Protein Kinase C, G Protein-Coupled Receptor Kinase, and Dynamin
Sudarat Nimitvilai, Maureen A. McElvain and Mark S. Brodie

Journal of Pharmacology and Experimental Therapeutics January 2013, 344 (1) 253-263; DOI: https://doi.org/10.1124/jpet.112.199844
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The Antinociceptive Effects of Nicotinic Receptors α7-Positive Allosteric Modulators in Murine Acute and Tonic Pain Models
Kelen Freitas, F. Ivy Carroll and M. Imad Damaj

Journal of Pharmacology and Experimental Therapeutics January 2013, 344 (1) 264-275; DOI: https://doi.org/10.1124/jpet.112.197871
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RETRACTION: Orexin-A Suppresses Postischemic Glucose Intolerance and Neuronal Damage through Hypothalamic Brain-Derived Neurotrophic Factor
Shinichi Harada, Yui Yamazaki and Shogo Tokuyama

Journal of Pharmacology and Experimental Therapeutics January 2013, 344 (1) 276-285; DOI: https://doi.org/10.1124/jpet.112.199604

Toxicology

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Mouse Liver Protein Sulfhydryl Depletion after Acetaminophen Exposure
Xi Yang, James Greenhaw, Qiang Shi, Dean W. Roberts, Jack A. Hinson, Levan Muskhelishvili, Kelly Davis and William F. Salminen

Journal of Pharmacology and Experimental Therapeutics January 2013, 344 (1) 286-294; DOI: https://doi.org/10.1124/jpet.112.199067
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Fetal Muscle-Type Nicotinic Acetylcholine Receptor Activation in TE-671 Cells and Inhibition of Fetal Movement in a Day 40 Pregnant Goat Model by Optical Isomers of the Piperidine Alkaloid Coniine
Benedict T. Green, Stephen T. Lee, Kevin D. Welch, James A. Pfister and Kip E. Panter

Journal of Pharmacology and Experimental Therapeutics January 2013, 344 (1) 295-307; DOI: https://doi.org/10.1124/jpet.112.199588
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Postexposure Application of Fas Receptor Small-Interfering RNA to Suppress Sulfur Mustard–Induced Apoptosis in Human Airway Epithelial Cells: Implication for a Therapeutic Approach
Brian M. Keyser, Devon K. Andres, Eric Nealley, Wesley W. Holmes, Betty Benton, Danielle Paradiso, Ashley Appell, Chris Carpin, Dana R. Anderson, William J. Smith and Radharaman Ray

Journal of Pharmacology and Experimental Therapeutics January 2013, 344 (1) 308-316; DOI: https://doi.org/10.1124/jpet.112.199935

Erratum

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Correction to Highlights: “Differential Effects of Selesipag and Prostacyclin Analogs in Rat Pulmonary Artery”
Journal of Pharmacology and Experimental Therapeutics January 2013, 344 (1) 317; DOI: https://doi.org/10.1124/jpet.112.01er13

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Table of Contents

Highlighted Papers

Perspectives in Pharmacology

Behavioral Pharmacology

Cardiovascular

Cellular and Molecular

Chemotherapy, Antibiotics, and Gene Therapy

Drug Discovery and Translational Medicine

Gastrointestinal, Hepatic, Pulmonary, and Renal

Inflammation, Immunopharmacology, and Asthma

Metabolism, Transport, and Pharmacogenomics

Neuropharmacology

Toxicology

Erratum

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