Journal of Pharmacology and Experimental Therapeutics: 338 (2)

August 01, 2011; Volume 338,Issue 2

Highlighted Papers

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Effectiveness of Therapeutic Antibodies against Bioterrorism and Biological Warfare
Journal of Pharmacology and Experimental Therapeutics August 2011, 338 (2) 411;
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Therapeutic Potential of siRNA Targeting RelA in Atopic Dermatitis
Journal of Pharmacology and Experimental Therapeutics August 2011, 338 (2) 411;
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Functional Cross-Talk between Purinergic and Cysteinyl-Leukotriene Ligands
Journal of Pharmacology and Experimental Therapeutics August 2011, 338 (2) 411;
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A New Profile Anticoagulant Combining Factor Xa and αIIbβ3 Inhibition
Journal of Pharmacology and Experimental Therapeutics August 2011, 338 (2) 411;

Behavioral Pharmacology

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The Role of 5-Hydroxytryptamine 7 Receptors in the Phencyclidine-Induced Novel Object Recognition Deficit in Rats
M. Horiguchi, M. Huang and H. Y. Meltzer

Journal of Pharmacology and Experimental Therapeutics August 2011, 338 (2) 605-614; DOI: https://doi.org/10.1124/jpet.111.180638
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Anxiolytic-Like Activity of Pregabalin in the Vogel Conflict Test in α₂δ-1 (R217A) and α₂δ-2 (R279A) Mouse Mutants
Susan M. Lotarski, Sean Donevan, Ayman El-Kattan, Sarah Osgood, Julie Poe, Charles P. Taylor and James Offord

Journal of Pharmacology and Experimental Therapeutics August 2011, 338 (2) 615-621; DOI: https://doi.org/10.1124/jpet.111.180976
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Effects of Repeated Treatment with Phosphodiesterase-4 Inhibitors on cAMP Signaling, Hippocampal Cell Proliferation, and Behavior in the Forced-Swim Test
Lan Xiao, James P. O'Callaghan and James M. O'Donnell

Journal of Pharmacology and Experimental Therapeutics August 2011, 338 (2) 641-647; DOI: https://doi.org/10.1124/jpet.111.179358

Cardiovascular

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The Antithrombotic Activity of EP224283, a Neutralizable Dual Factor Xa Inhibitor/Glycoprotein IIbIIIa Antagonist, Exceeds That of the Coadministered Parent Compounds
Béatrice Hechler, Monique Freund, Ghina Alame, Cécile Leguay, Sébastien Gaertner, Jean-Pierre Cazenave, Maurice Petitou and Christian Gachet

Journal of Pharmacology and Experimental Therapeutics August 2011, 338 (2) 412-420; DOI: https://doi.org/10.1124/jpet.111.181321
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Combinatorial Effect of Probucol and Cilostazol in Focal Ischemic Mice with Hypercholesterolemia
Ji Hyun Kim, Sun Haeng Park, Sun Sik Bae, Ki Whan Hong, Yong Deok Kim, Kyung Pil Park, Byung Tae Choi and Hwa Kyoung Shin

Journal of Pharmacology and Experimental Therapeutics August 2011, 338 (2) 451-457; DOI: https://doi.org/10.1124/jpet.111.181180
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Hydrogen Sulfide in the Rostral Ventrolateral Medulla Inhibits Sympathetic Vasomotor Tone through ATP-Sensitive K⁺ Channels
Qi Guo, Sheng Jin, Xiu-Li Wang, Ru Wang, Lin Xiao, Rui-rong He and Yu-ming Wu

Journal of Pharmacology and Experimental Therapeutics August 2011, 338 (2) 458-465; DOI: https://doi.org/10.1124/jpet.111.180711
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Compound C Inhibits Vascular Smooth Muscle Cell Proliferation and Migration in an AMP-Activated Protein Kinase-Independent Fashion
Kelly J. Peyton, Yajie Yu, Benjamin Yates, Ahmad R. Shebib, Xiao-ming Liu, Hong Wang and William Durante

Journal of Pharmacology and Experimental Therapeutics August 2011, 338 (2) 476-484; DOI: https://doi.org/10.1124/jpet.111.181784
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Astragaloside IV Stimulates Angiogenesis and Increases Hypoxia-Inducible Factor-1α Accumulation via Phosphatidylinositol 3-Kinase/Akt Pathway
Ling Zhang, Qian Liu, Lin Lu, Xiaoping Zhao, Xiumei Gao and Yi Wang

Journal of Pharmacology and Experimental Therapeutics August 2011, 338 (2) 485-491; DOI: https://doi.org/10.1124/jpet.111.180992
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NADPH Oxidase Pathway Is Involved in Aortic Contraction Induced by A₃ Adenosine Receptor in Mice
Mohammed S. El-Awady, Habib R. Ansari, Daniel Fil, Stephen L. Tilley and S. Jamal Mustafa

Journal of Pharmacology and Experimental Therapeutics August 2011, 338 (2) 711-717; DOI: https://doi.org/10.1124/jpet.111.180828

Cellular and Molecular

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The Cytochrome P450 4A/F-20-Hydroxyeicosatetraenoic Acid System: A Regulator of Endothelial Precursor Cells Derived from Human Umbilical Cord Blood
Austin M. Guo, Branislava Janic, Ju Sheng, John R. Falck, Richard J. Roman, Paul A. Edwards, Ali S. Arbab and A. Guillermo Scicli

Journal of Pharmacology and Experimental Therapeutics August 2011, 338 (2) 421-429; DOI: https://doi.org/10.1124/jpet.111.179036
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Salt Bridges Overlapping the Gonadotropin-Releasing Hormone Receptor Agonist Binding Site Reveal a Coincidence Detector for G Protein-Coupled Receptor Activation
Jo Ann Janovick, Irina D. Pogozheva, Henry I. Mosberg and P. Michael Conn

Journal of Pharmacology and Experimental Therapeutics August 2011, 338 (2) 430-442; DOI: https://doi.org/10.1124/jpet.111.180869
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Agonist-Induced Desensitization/Resensitization of Human G Protein-Coupled Receptor 17: A Functional Cross-Talk between Purinergic and Cysteinyl-Leukotriene Ligands
S. Daniele, M. L. Trincavelli, P. Gabelloni, D. Lecca, P. Rosa, M. P. Abbracchio and C. Martini

Journal of Pharmacology and Experimental Therapeutics August 2011, 338 (2) 559-567; DOI: https://doi.org/10.1124/jpet.110.178715
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Analysis of Functional Responses at G Protein-Coupled Receptors: Estimation of Relative Affinity Constants for the Inactive Receptor State
Frederick J. Ehlert, Michael T. Griffin and Hinako Suga

Journal of Pharmacology and Experimental Therapeutics August 2011, 338 (2) 658-670; DOI: https://doi.org/10.1124/jpet.111.179291
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Analysis of Agonism and Inverse Agonism in Functional Assays with Constitutive Activity: Estimation of Orthosteric Ligand Affinity Constants for Active and Inactive Receptor States
Frederick J. Ehlert, Hinako Suga and Michael T. Griffin

Journal of Pharmacology and Experimental Therapeutics August 2011, 338 (2) 671-686; DOI: https://doi.org/10.1124/jpet.111.179309
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Na_Vβ Subunits Modulate the Inhibition of Na_V1.8 by the Analgesic Gating Modifier μO-Conotoxin MrVIB
Michael J. Wilson, Min-Min Zhang, Layla Azam, Baldomero M. Olivera, Grzegorz Bulaj and Doju Yoshikami

Journal of Pharmacology and Experimental Therapeutics August 2011, 338 (2) 687-693; DOI: https://doi.org/10.1124/jpet.110.178343
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Involvement of Matrix Metalloproteinase-Mediated Proteolysis of Neural Cell Adhesion Molecule in the Development of Cerebral Ischemic Neuronal Damage
Kanako Shichi, Wakako Fujita-Hamabe, Shinichi Harada, Hiroyuki Mizoguchi, Kiyofumi Yamada, Toshitaka Nabeshima and Shogo Tokuyama

Journal of Pharmacology and Experimental Therapeutics August 2011, 338 (2) 701-710; DOI: https://doi.org/10.1124/jpet.110.178079

Chemotherapy, Antibiotics, and Gene Therapy

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Therapeutic Effects on Atopic Dermatitis by Anti-RelA Short Interfering RNA Combined with Functional Peptides Tat and AT1002
Tamae Uchida, Takanori Kanazawa, Misako Kawai, Yuuki Takashima and Hiroaki Okada

Journal of Pharmacology and Experimental Therapeutics August 2011, 338 (2) 443-450; DOI: https://doi.org/10.1124/jpet.111.180042
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A Calcineurin-Independent Mechanism of Angiogenesis Inhibition by a Nonimmunosuppressive Cyclosporin A Analog
Benjamin A. Nacev, Woon-Kai Low, Zhennian Huang, Tina T. Su, Zhuang Su, Hisham Alkuraya, Dan Kasuga, Woong Sun, Mario Träger, Manfred Braun, Gunter Fischer, Kang Zhang and Jun O. Liu

Journal of Pharmacology and Experimental Therapeutics August 2011, 338 (2) 466-475; DOI: https://doi.org/10.1124/jpet.111.180851
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Oxaliplatin Transport Mediated by Organic Cation/Carnitine Transporters OCTN1 and OCTN2 in Overexpressing Human Embryonic Kidney 293 Cells and Rat Dorsal Root Ganglion Neurons
Nancy N. Jong, Takeo Nakanishi, Johnson J. Liu, Ikumi Tamai and Mark J. McKeage

Journal of Pharmacology and Experimental Therapeutics August 2011, 338 (2) 537-547; DOI: https://doi.org/10.1124/jpet.111.181297

Drug Discovery and Translational Medicine

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A Rate-Limiting Role for Dickkopf-1 in Bone Formation and the Remediation of Bone Loss in Mouse and Primate Models of Postmenopausal Osteoporosis by an Experimental Therapeutic Antibody
Helmut Glantschnig, Kevin Scott, Richard Hampton, Nan Wei, Paul McCracken, Pascale Nantermet, Jing Z. Zhao, Salvatore Vitelli, Lingyi Huang, Peter Haytko, Ping Lu, John E. Fisher, Punam Sandhu, Jacquelynn Cook, Donald Williams, William Strohl, Osvaldo Flores, Donald Kimmel, Fubao Wang and Zhiqiang An

Journal of Pharmacology and Experimental Therapeutics August 2011, 338 (2) 568-578; DOI: https://doi.org/10.1124/jpet.111.181404

Endocrine and Diabetes

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Decreased Cytochrome c Oxidase IV Expression Reduces Steroidogenesis
Kevin J. Pawlak, Manoj Prasad, Kevin A. McKenzie, John P. Wiebe, C. Gary Gairola, Randy M. Whittal and Himangshu S. Bose

Journal of Pharmacology and Experimental Therapeutics August 2011, 338 (2) 598-604; DOI: https://doi.org/10.1124/jpet.111.182634

Gastrointestinal, Hepatic, Pulmonary, and Renal

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Intermediate-Conductance Ca²⁺-Activated K⁺ Channel, K_Ca3.1, as a Novel Therapeutic Target for Benign Prostatic Hyperplasia
Susumu Ohya, Satomi Niwa, Yoshiyuki Kojima, Shoichi Sasaki, Motomu Sakuragi, Kenjiro Kohri and Yuji Imaizumi

Journal of Pharmacology and Experimental Therapeutics August 2011, 338 (2) 528-536; DOI: https://doi.org/10.1124/jpet.111.182782

Inflammation, Immunopharmacology, and Asthma

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Paw Inflammation Model in Dogs for Preclinical Pharmacokinetic/Pharmacodynamic Investigations of Nonsteroidal Anti-Inflammatory Drugs
E. C. Jeunesse, I. A. Bargues, C. E. Toutain, M. Z. Lacroix, I. M. Letellier, J. M. Giraudel and P. L. Toutain

Journal of Pharmacology and Experimental Therapeutics August 2011, 338 (2) 548-558; DOI: https://doi.org/10.1124/jpet.110.178350
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α₁-Adrenergic Receptors Positively Regulate Toll-Like Receptor Cytokine Production from Human Monocytes and Macrophages
Laurel A. Grisanti, Andrew P. Woster, Julie Dahlman, Edward R. Sauter, Colin K. Combs and James E. Porter

Journal of Pharmacology and Experimental Therapeutics August 2011, 338 (2) 648-657; DOI: https://doi.org/10.1124/jpet.110.178012

Metabolism, Transport, and Pharmacogenomics

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Physiological and Molecular Characterization of Aristolochic Acid Transport by the Kidney
Kathleen G. Dickman, Douglas H. Sweet, Radha Bonala, Tapan Ray and Amy Wu

Journal of Pharmacology and Experimental Therapeutics August 2011, 338 (2) 588-597; DOI: https://doi.org/10.1124/jpet.111.180984

Neuropharmacology

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Pentazocine-Induced Antinociception Is Mediated Mainly by μ-Opioid Receptors and Compromised by κ-Opioid Receptors in Mice
Haihua Shu, Masakazu Hayashida, Hideko Arita, Wenqi Huang, Hui Zhang, Ke An, Guiyun Wu and Kazuo Hanaoka

Journal of Pharmacology and Experimental Therapeutics August 2011, 338 (2) 579-587; DOI: https://doi.org/10.1124/jpet.111.179879
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Pharmacological Characterization of LY593093, an M1 Muscarinic Acetylcholine Receptor-Selective Partial Orthosteric Agonist
Marla L. Watt, Douglas A. Schober, Stephen Hitchcock, Bin Liu, Amy K. Chesterfield, David McKinzie and Christian C. Felder

Journal of Pharmacology and Experimental Therapeutics August 2011, 338 (2) 622-632; DOI: https://doi.org/10.1124/jpet.111.182063
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A Novel Knock-In Mouse Reveals Mechanistically Distinct Forms of Morphine Tolerance
Johan Enquist, Joseph A. Kim, Selena Bartlett, Madeline Ferwerda and Jennifer L. Whistler

Journal of Pharmacology and Experimental Therapeutics August 2011, 338 (2) 633-640; DOI: https://doi.org/10.1124/jpet.111.179754
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The Akt-Nitric Oxide-cGMP Pathway Contributes to Nerve Growth Factor-Mediated Neurite Outgrowth in Apolipoprotein E Knockout Mice
Narumi Hashikawa-Hobara, Naoya Hashikawa, Chikao Yutani, Yoshito Zamami, Xin Jin, Shingo Takatori, Mitsunobu Mio and Hiromu Kawasaki

Journal of Pharmacology and Experimental Therapeutics August 2011, 338 (2) 694-700; DOI: https://doi.org/10.1124/jpet.111.181487
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The Affinity of D₂-Like Dopamine Receptor Antagonists Determines the Time to Maximal Effect on Cocaine Self-Administration
Andrew B. Norman, Michael R. Tabet, Mantana K. Norman, Brittney K. Fey, Vladimir L. Tsibulsky and Ronald W. Millard

Journal of Pharmacology and Experimental Therapeutics August 2011, 338 (2) 724-728; DOI: https://doi.org/10.1124/jpet.111.183244

Toxicology

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The Role of Hypoxia-Inducible Factor-1α in Acetaminophen Hepatotoxicity
Erica M. Sparkenbaugh, Yogesh Saini, Krista K. Greenwood, John J. LaPres, James P. Luyendyk, Bryan L. Copple, Jane F. Maddox, Patricia E. Ganey and Robert A. Roth

Journal of Pharmacology and Experimental Therapeutics August 2011, 338 (2) 492-502; DOI: https://doi.org/10.1124/jpet.111.180521
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Identification of the Factors That Govern the Ability of Therapeutic Antibodies to Provide Postchallenge Protection Against Botulinum Toxin: A Model for Assessing Postchallenge Efficacy of Medical Countermeasures against Agents of Bioterrorism and Biological Warfare
Fetweh H. Al-Saleem, Zidoon Nasser, Rebecca M. Olson, Linsen Cao and Lance L. Simpson

Journal of Pharmacology and Experimental Therapeutics August 2011, 338 (2) 503-517; DOI: https://doi.org/10.1124/jpet.111.180653
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Exposure to an Environmental Neurotoxicant Hastens the Onset of Amyotrophic Lateral Sclerosis-Like Phenotype in Human Cu²⁺/Zn²⁺ Superoxide Dismutase 1 G93A Mice: Glutamate-Mediated Excitotoxicity
Frank O. Johnson, Yukun Yuan, Ravindra K. Hajela, Alisha Chitrakar, Dawn M. Parsell and William D. Atchison

Journal of Pharmacology and Experimental Therapeutics August 2011, 338 (2) 518-527; DOI: https://doi.org/10.1124/jpet.110.174466
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Influence of Dosing Time on the Efficacy and Safety of Finasteride in Rats
Masafumi Kumazaki, Hitoshi Ando, Kentarou Ushijima, Tomohiro Maekawa, Yuya Motosugi, Makoto Takada, Masato Tateishi and Akio Fujimura

Journal of Pharmacology and Experimental Therapeutics August 2011, 338 (2) 718-723; DOI: https://doi.org/10.1124/jpet.111.182865

Erratum

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Correction to “The Microtubule-Targeting Agents, PBOX-6 [Pyrrolobenzoxazepine 7-[(dimethylcarbamoyl)oxy]-6-(2-naphthyl)pyrrolo-[2,1-d] (1,5)-benzoxazepine] and Paclitaxel, Induce Nucleocytoplasmic Redistribution of the Peptidyl-Prolyl Isomerases, Cyclophilin A and Pin1, in Malignant Hematopoietic Cells”
Journal of Pharmacology and Experimental Therapeutics August 2011, 338 (2) 729;

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Table of Contents

Highlighted Papers

Behavioral Pharmacology

Cardiovascular

Cellular and Molecular

Chemotherapy, Antibiotics, and Gene Therapy

Drug Discovery and Translational Medicine

Endocrine and Diabetes

Gastrointestinal, Hepatic, Pulmonary, and Renal

Inflammation, Immunopharmacology, and Asthma

Metabolism, Transport, and Pharmacogenomics

Neuropharmacology

Toxicology

Erratum

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