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Research ArticleNEUROPHARMACOLOGY

(R)-(5-tert-Butyl-2,3-dihydro-1H-inden-1-yl)-3-(1H-indazol-4-yl)-urea (ABT-102) Blocks Polymodal Activation of Transient Receptor Potential Vanilloid 1 Receptors in Vitro and Heat-Evoked Firing of Spinal Dorsal Horn Neurons in Vivo

Carol S. Surowy, Torben R. Neelands, Bruce R. Bianchi, Steve McGaraughty, Rachid El Kouhen, Ping Han, Katharine L. Chu, Heath A. McDonald, Melissa Vos, Wende Niforatos, Erol K. Bayburt, Arthur Gomtsyan, Chih-Hung Lee, Prisca Honore, James P. Sullivan, Michael F. Jarvis and Connie R. Faltynek
Journal of Pharmacology and Experimental Therapeutics September 2008, 326 (3) 879-888; DOI: https://doi.org/10.1124/jpet.108.138511

Article Information

vol. 326 no. 3 879-888
DOI 
https://doi.org/10.1124/jpet.108.138511
PubMed 
18515644
Published By 
American Society for Pharmacology and Experimental Therapeutics
Print ISSN 
0022-3565
Online ISSN 
1521-0103
History 
  • Received February 28, 2008
  • Accepted May 29, 2008
  • Published online August 18, 2008.

Article Versions

Copyright & Usage 
The American Society for Pharmacology and Experimental Therapeutics

Author Information

  1. Carol S. Surowy,
  2. Torben R. Neelands,
  3. Bruce R. Bianchi,
  4. Steve McGaraughty,
  5. Rachid El Kouhen,
  6. Ping Han,
  7. Katharine L. Chu,
  8. Heath A. McDonald,
  9. Melissa Vos,
  10. Wende Niforatos,
  11. Erol K. Bayburt,
  12. Arthur Gomtsyan,
  13. Chih-Hung Lee,
  14. Prisca Honore,
  15. James P. Sullivan,
  16. Michael F. Jarvis and
  17. Connie R. Faltynek
  1. Neuroscience Research, Global Pharmaceutical Research and Development, Abbott Laboratories, Abbott Park, Illinois
  1. Address correspondence to:
    Dr. Carol S. Surowy, Abbott Laboratories, R4PM, AP9/1, 100 Abbott Park Road, Abbott Park, IL 60064-6118. E-mail: carol.s.surowy{at}abbott.com
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Research ArticleNEUROPHARMACOLOGY

(R)-(5-tert-Butyl-2,3-dihydro-1H-inden-1-yl)-3-(1H-indazol-4-yl)-urea (ABT-102) Blocks Polymodal Activation of Transient Receptor Potential Vanilloid 1 Receptors in Vitro and Heat-Evoked Firing of Spinal Dorsal Horn Neurons in Vivo

Carol S. Surowy, Torben R. Neelands, Bruce R. Bianchi, Steve McGaraughty, Rachid El Kouhen, Ping Han, Katharine L. Chu, Heath A. McDonald, Melissa Vos, Wende Niforatos, Erol K. Bayburt, Arthur Gomtsyan, Chih-Hung Lee, Prisca Honore, James P. Sullivan, Michael F. Jarvis and Connie R. Faltynek
Journal of Pharmacology and Experimental Therapeutics September 1, 2008, 326 (3) 879-888; DOI: https://doi.org/10.1124/jpet.108.138511
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