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Research ArticleNEUROPHARMACOLOGY

Fenobam: A Clinically Validated Nonbenzodiazepine Anxiolytic Is a Potent, Selective, and Noncompetitive mGlu5 Receptor Antagonist with Inverse Agonist Activity

Richard H. P. Porter, Georg Jaeschke, Will Spooren, Theresa M. Ballard, Bernd Büttelmann, Sabine Kolczewski, Jens-Uwe Peters, Eric Prinssen, Jürgen Wichmann, Eric Vieira, Andreas Mühlemann, Silvia Gatti, Vincent Mutel and Pari Malherbe
Journal of Pharmacology and Experimental Therapeutics November 2005, 315 (2) 711-721; DOI: https://doi.org/10.1124/jpet.105.089839

Article Information

vol. 315 no. 2 711-721
DOI 
https://doi.org/10.1124/jpet.105.089839
PubMed 
16040814
Published By 
American Society for Pharmacology and Experimental Therapeutics
Print ISSN 
0022-3565
Online ISSN 
1521-0103
History 
  • Received May 19, 2005
  • Accepted July 19, 2005
  • Published online October 19, 2005.

Article Versions

Copyright & Usage 
The American Society for Pharmacology and Experimental Therapeutics

Author Information

  1. Richard H. P. Porter,
  2. Georg Jaeschke,
  3. Will Spooren,
  4. Theresa M. Ballard,
  5. Bernd Büttelmann,
  6. Sabine Kolczewski,
  7. Jens-Uwe Peters,
  8. Eric Prinssen,
  9. Jürgen Wichmann,
  10. Eric Vieira,
  11. Andreas Mühlemann,
  12. Silvia Gatti,
  13. Vincent Mutel1 and
  14. Pari Malherbe
  1. Pharma Division, Discovery Research CNS (R.H.P.P., W.S., T.M.B., A.M., E.P., A.M., S.G., V.M., P.M.) and Chemistry (G.J., B.B., S.K., J.-U.P., J.W., E.V.), F. Hoffmann-La Roche, Basel, Switzerland
  1. Address correspondence to:
    Dr. Richard Porter, F. Hoffmann-La Roche, PRBD-N, Bldg. 69/452, CH-4070 Basel, Switzerland. E-mail: richard.porter{at}roche.com
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Research ArticleNEUROPHARMACOLOGY

Fenobam: A Clinically Validated Nonbenzodiazepine Anxiolytic Is a Potent, Selective, and Noncompetitive mGlu5 Receptor Antagonist with Inverse Agonist Activity

Richard H. P. Porter, Georg Jaeschke, Will Spooren, Theresa M. Ballard, Bernd Büttelmann, Sabine Kolczewski, Jens-Uwe Peters, Eric Prinssen, Jürgen Wichmann, Eric Vieira, Andreas Mühlemann, Silvia Gatti, Vincent Mutel and Pari Malherbe
Journal of Pharmacology and Experimental Therapeutics November 1, 2005, 315 (2) 711-721; DOI: https://doi.org/10.1124/jpet.105.089839
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