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Research ArticleCELLULAR AND MOLECULAR

Y-700 [1-[3-Cyano-4-(2,2-dimethylpropoxy)phenyl]-1H-pyrazole-4-carboxylic Acid]: A Potent Xanthine Oxidoreductase Inhibitor with Hepatic Excretion

Atsushi Fukunari, Ken Okamoto, Takeshi Nishino, Bryan T. Eger, Emil F. Pai, Miho Kamezawa, Ichimaro Yamada and Norihisa Kato
Journal of Pharmacology and Experimental Therapeutics November 2004, 311 (2) 519-528; DOI: https://doi.org/10.1124/jpet.104.070433

Article Information

vol. 311 no. 2 519-528
DOI 
https://doi.org/10.1124/jpet.104.070433
PubMed 
15190124
Published By 
American Society for Pharmacology and Experimental Therapeutics
Print ISSN 
0022-3565
Online ISSN 
1521-0103
History 
  • Received April 23, 2004
  • Accepted June 8, 2004
  • Published online October 13, 2004.

Article Versions

Copyright & Usage 
The American Society for Pharmacology and Experimental Therapeutics

Author Information

  1. Atsushi Fukunari,
  2. Ken Okamoto,
  3. Takeshi Nishino,
  4. Bryan T. Eger,
  5. Emil F. Pai,
  6. Miho Kamezawa,
  7. Ichimaro Yamada and
  8. Norihisa Kato
  1. Pharmaceutical Research Unit, Mitsubishi Pharma Corporation, Yokohama, Japan (A.F., M.K., I.Y.); Department of Biochemistry and Molecular Biology, Nippon Medical School, Tokyo, Japan (K.O., T.N.); Department of Biochemistry, University of Toronto, Toronto, Ontario, Canada (B.T.E.); Departments of Biochemistry, Medical Biophysics, and Medical Genetics and Microbiology, University of Toronto and Division of Molecular and Structural Biology, Ontario Cancer Institute/Princess Margaret Hospital, Toronto, Ontario, Canada (E.F.P.); and Department of Bioresource Science and Technology, Hiroshima University, Hiroshima, Japan (N.K.)
  1. Address correspondence to:
    Atsushi Fukunari, Discovery Technology Laboratory, Pharmaceuticals Research Unit, Mitsubishi Pharma Corporation, 1000 Kamoshida-cho, Aoba-ku, Yokohama 227-0033, Japan. E-mail: fukunari.atsushi{at}mb.m-pharma.co.jp
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Research ArticleCELLULAR AND MOLECULAR

Y-700 [1-[3-Cyano-4-(2,2-dimethylpropoxy)phenyl]-1H-pyrazole-4-carboxylic Acid]: A Potent Xanthine Oxidoreductase Inhibitor with Hepatic Excretion

Atsushi Fukunari, Ken Okamoto, Takeshi Nishino, Bryan T. Eger, Emil F. Pai, Miho Kamezawa, Ichimaro Yamada and Norihisa Kato
Journal of Pharmacology and Experimental Therapeutics November 1, 2004, 311 (2) 519-528; DOI: https://doi.org/10.1124/jpet.104.070433
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