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Research ArticleCELLULAR AND MOLECULAR

β1-Selective Agonist (−)-1-(3,4-Dimethoxyphenetylamino)-3-(3,4-dihydroxy)-2-propanol [(−)-RO363] Differentially Interacts with Key Amino Acids Responsible for β1-Selective Binding in Resting and Active States

Yoshiyuki Sugimoto, Reiko Fujisawa, Ryuji Tanimura, Anne Laure Lattion, Susanna Cotecchia, Gozoh Tsujimoto, Taku Nagao and Hitoshi Kurose
Journal of Pharmacology and Experimental Therapeutics April 2002, 301 (1) 51-58; DOI: https://doi.org/10.1124/jpet.301.1.51

Article Information

vol. 301 no. 1 51-58
DOI 
https://doi.org/10.1124/jpet.301.1.51
PubMed 
11907156
Published By 
American Society for Pharmacology and Experimental Therapeutics
Print ISSN 
0022-3565
Online ISSN 
1521-0103
History 
  • Received November 5, 2001
  • Accepted December 19, 2001
  • Published online April 1, 2002.
Copyright & Usage 
The American Society for Pharmacology and Experimental Therapeutics

Author Information

  1. Yoshiyuki Sugimoto1,1,
  2. Reiko Fujisawa1,
  3. Ryuji Tanimura2,
  4. Anne Laure Lattion4,
  5. Susanna Cotecchia4,
  6. Gozoh Tsujimoto3,
  7. Taku Nagao1 and
  8. Hitoshi Kurose1
  1. 1Laboratory of Pharmacology and Toxicology, Graduate School of Pharmaceutical Sciences, University of Tokyo, Tokyo, Japan (Y.S., R.F., T.N., H.K.); 2Toray Industries, Inc., Basic Research Laboratories, Kanagawa, Japan (R.T.); 3Department of Molecular, Cell Pharmacology, National Children's Medical Research Center, Tokyo, Japan (G.T.); and 4Institute de Pharmacologie et de Toxicologie, Lausanne, Switzerland (A.L.L., S.C.)
  1. Hitoshi Kurose, Ph.D., Laboratory of Pharmacology and Toxicology, Graduate School of Pharmaceutical Sciences, University of Tokyo, Tokyo 113-0033, Japan. E-mail: kurose{at}mol.f.u-tokyo.ac.jp
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Research ArticleCELLULAR AND MOLECULAR

β1-Selective Agonist (−)-1-(3,4-Dimethoxyphenetylamino)-3-(3,4-dihydroxy)-2-propanol [(−)-RO363] Differentially Interacts with Key Amino Acids Responsible for β1-Selective Binding in Resting and Active States

Yoshiyuki Sugimoto, Reiko Fujisawa, Ryuji Tanimura, Anne Laure Lattion, Susanna Cotecchia, Gozoh Tsujimoto, Taku Nagao and Hitoshi Kurose
Journal of Pharmacology and Experimental Therapeutics April 1, 2002, 301 (1) 51-58; DOI: https://doi.org/10.1124/jpet.301.1.51
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