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Research ArticleNEUROPHARMACOLOGY

Insights into the Mechanisms of Ifosfamide Encephalopathy: Drug Metabolites Have Agonistic Effects on α-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid (AMPA)/Kainate Receptors and Induce Cellular Acidification in Mouse Cortical Neurons

Jean-Yves Chatton, Jeffrey R. Idle, Cathrine Broberg Vågbø and Pierre J. Magistretti
Journal of Pharmacology and Experimental Therapeutics December 2001, 299 (3) 1161-1168;

Article Information

vol. 299 no. 3 1161-1168
PubMed 
11714908
Published By 
American Society for Pharmacology and Experimental Therapeutics
Print ISSN 
0022-3565
Online ISSN 
1521-0103
History 
  • Received May 14, 2001
  • Accepted August 31, 2001
  • Published online December 1, 2001.
Copyright & Usage 
The American Society for Pharmacology and Experimental Therapeutics

Author Information

  1. Jean-Yves Chatton1,
  2. Jeffrey R. Idle1,2,
  3. Cathrine Broberg Vågbø2 and
  4. Pierre J. Magistretti1
  1. 1Institute of Physiology and Laboratory of Neurological Research, Department of Neurology, University of Lausanne Medical School, Lausanne, Switzerland (J.-Y.C., P.J.M.); and 2Institute for Cancer Research and Molecular Biology, Norwegian University of Science and Technology, Trondheim, Norway (J.R.I., C.B.V.)
  1. Dr. Jean-Yves Chatton, Institute of Physiology, University of Lausanne, Rue du Bugnon 7, CH-1005 Lausanne, Switzerland. E-mail: jean-yves.chatton{at}iphysiol.unil.ch
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Research ArticleNEUROPHARMACOLOGY

Insights into the Mechanisms of Ifosfamide Encephalopathy: Drug Metabolites Have Agonistic Effects on α-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid (AMPA)/Kainate Receptors and Induce Cellular Acidification in Mouse Cortical Neurons

Jean-Yves Chatton, Jeffrey R. Idle, Cathrine Broberg Vågbø and Pierre J. Magistretti
Journal of Pharmacology and Experimental Therapeutics December 1, 2001, 299 (3) 1161-1168;
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