Abstract
Treatment of ovariectomized rats with dietary clofibrate caused a manyfold increase in the liver microsomal esterification of estradiol with fatty acids. The stimulatory effect of clofibrate administration on fatty acid esterification of estradiol by liver microsomes was paralleled in vivo by enhanced estradiol-induced increases in the formation of lobules in the mammary gland and by increased incorporation of bromodeoxyuridine into these lobules. In contrast to the stimulatory effect of clofibrate administration on the action of estradiol in the mammary gland, clofibrate administration had no effect on the uterotropic action of estradiol. These results indicate that clofibrate administration has a selective stimulatory effect on the hormonal action of estradiol in the mammary gland but not in the uterus.
Footnotes
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Send reprint requests to: Dr. Allan H. Conney, Laboratory for Cancer Research, Department of Chemical Biology, College of Pharmacy, Rutgers, The State University of New Jersey, 164 Frelinghuysen Rd., Piscataway, NJ 08854-8020. E-mail:aconney{at}rci.rutgers.edu
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↵1 Present address: Department of Basic Pharmaceutical Sciences, College of Pharmacy, University of South Carolina, Columbia, SC 29208.
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↵2 William M. and Myrle W. Garbe Professor of Cancer and Leukemia Research.
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This work was supported by unrestricted donations to the Department of Chemical Biology, College of Pharmacy, Rutgers, The State University of New Jersey, Piscataway, NJ.
- Abbreviations:
- HPLC
- high performance liquid chromatography
- BrdU
- bromodeoxyuridine
- Received September 19, 2000.
- Accepted December 1, 2000.
- The American Society for Pharmacology and Experimental Therapeutics
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