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Research ArticleNEUROPHARMACOLOGY

S18327 (1-{2-[4-(6-Fluoro-1,2-benzisoxazol-3-yl)piperid-1-yl]ethyl}3-phenyl imidazolin-2-one), a Novel, Potential Antipsychotic Displaying Marked Antagonist Properties at α1- and α2-Adrenergic Receptors: II. Functional Profile and a Multiparametric Comparison with Haloperidol, Clozapine, and 11 Other Antipsychotic Agents

Mark J. Millan, Mauricette Brocco, Jean-Michel Rivet, Valérie Audinot, Adrian Newman-Tancredi, Lisa Maiofiss, Sophie Queriaux, Nicole Despaux, Jean-Louis Peglion and Anne Dekeyne
Journal of Pharmacology and Experimental Therapeutics January 2000, 292 (1) 54-66;

Article Information

vol. 292 no. 1 54-66
PubMed 
10604931
Published By 
American Society for Pharmacology and Experimental Therapeutics
Print ISSN 
0022-3565
Online ISSN 
1521-0103
History 
  • Received June 7, 1999
  • Accepted September 22, 1999
  • Published online January 1, 2000.
Copyright & Usage 
The American Society for Pharmacology and Experimental Therapeutics

Author Information

  1. Mark J. Millan1,
  2. Mauricette Brocco1,
  3. Jean-Michel Rivet1,
  4. Valérie Audinot1,
  5. Adrian Newman-Tancredi1,
  6. Lisa Maiofiss2,
  7. Sophie Queriaux2,
  8. Nicole Despaux3,
  9. Jean-Louis Peglion3 and
  10. Anne Dekeyne1
  1. 1Psychopharmacology Department, Institut de Recherches Servier, Centre de Recherches de Croissy, Paris, Croissy-sur-Seine, France (M.J.M., M.B., J.-M.R., V.A., A.N.-T., A.D.); and 2Statistics (L.M., S.Q.) and 3Chemistry B (N.P., J.-L.P.) Departments, Institut de Recherches Servier, Centre de Recherches de Suresnes, Suresnes, France
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    Research ArticleNEUROPHARMACOLOGY

    S18327 (1-{2-[4-(6-Fluoro-1,2-benzisoxazol-3-yl)piperid-1-yl]ethyl}3-phenyl imidazolin-2-one), a Novel, Potential Antipsychotic Displaying Marked Antagonist Properties at α1- and α2-Adrenergic Receptors: II. Functional Profile and a Multiparametric Comparison with Haloperidol, Clozapine, and 11 Other Antipsychotic Agents

    Mark J. Millan, Mauricette Brocco, Jean-Michel Rivet, Valérie Audinot, Adrian Newman-Tancredi, Lisa Maiofiss, Sophie Queriaux, Nicole Despaux, Jean-Louis Peglion and Anne Dekeyne
    Journal of Pharmacology and Experimental Therapeutics January 1, 2000, 292 (1) 54-66;
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