Journal of Pharmacology and Experimental Therapeutics: 281 (2)

May 01, 1997; Volume 281,Issue 2

ANALGESIA AND DRUGS OF ABUSE

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Mechanism of Attenuation of Morphine Antinociception by Chronic Treatment with l-Arginine
Hemendra N. Bhargava, Jing-Tan Bian and Shailendra Kumar

Journal of Pharmacology and Experimental Therapeutics May 1997, 281 (2) 707-712;
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Pharmacodynamics and Tolerance Development During Multiple Intravenous Bolus Morphine Administration in Rats
Danièle M.-C. Ouellet and Gary M. Pollack

Journal of Pharmacology and Experimental Therapeutics May 1997, 281 (2) 713-720;
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Involvement of Dynorphin B in the Antinociceptive Effects of the Cannabinoid CP55,940 in the Spinal Cord
George Pugh, David J. Mason, Vera Combs and Sandra P. Welch

Journal of Pharmacology and Experimental Therapeutics May 1997, 281 (2) 730-737;
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Almost Complete Protection from [Met⁵]-Enkephalin-Arg⁶-Gly⁷-Leu⁸(Met-enk-RGL) Hydrolysis in Membrane Preparations by the Combination of Amastatin, Captopril and Phosphoramidon
Toyokazu Hiranuma, Kayoko Iwao, Ken Kitamura, Teruhiko Matsumiya and Tetsuo Oka

Journal of Pharmacology and Experimental Therapeutics May 1997, 281 (2) 769-774;
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Changes in Sensitivity to the Rate-Decreasing Effects of Opioids in Pigeons Treated Acutely or Chronically with l-α-Acetylmethadol
Lisa R. Gerak and Charles P. France

Journal of Pharmacology and Experimental Therapeutics May 1997, 281 (2) 799-809;
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M₁ Receptor Agonist Activity Is Not a Requirement for Muscarinic Antinociception
Malcolm J. Sheardown, Harlan E. Shannon, Michael D. B. Swedberg, Peter D. Suzdak, Frank P. Bymaster, Preben H. Olesen, Charles H. Mitch, John S. Ward and Per Sauerberg

Journal of Pharmacology and Experimental Therapeutics May 1997, 281 (2) 868-875;
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Butylthio[2.2.2] (NNC 11–1053/LY297802): An Orally Active Muscarinic Agonist Analgesic
Michael D. B. Swedberg, Malcolm J. Sheardown, Per Sauerberg, Preben H. Olesen, Peter D. Suzdak, Kristian T. Hansen, Frank P. Bymaster, John S. Ward, Charles H. Mitch, David O. Calligaro, Neil W. Delapp and Harlan E. Shannon

Journal of Pharmacology and Experimental Therapeutics May 1997, 281 (2) 876-883;
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Pharmacology of Butylthio[2.2.2] (LY297802/NNC11-1053): A Novel Analgesic with Mixed Muscarinic Receptor Agonist and Antagonist Activity
Harlan E. Shannon, Malcolm J. Sheardown, Frank P. Bymaster, David O. Calligaro, Neil W. Delapp, Jaswant Gidda, Charles H. Mitch, Barry D. Sawyer, Peter W. Stengel, John S. Ward, David T. Wong, Preben H. Olesen, Peter D. Suzdak, Per Sauerberg and Michael D. B. Swedberg

Journal of Pharmacology and Experimental Therapeutics May 1997, 281 (2) 884-894;
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An Antisense Oligonucleotide on the MouseShaker-like Potassium Channel Kv1.1 Gene Prevents Antinociception Induced by Morphine and Baclofen
Nicoletta Galeotti, Carla Ghelardini, Laura Papucci, Sergio Capaccioli, Alessandro Quattrone and Alessandro Bartolini

Journal of Pharmacology and Experimental Therapeutics May 1997, 281 (2) 941-949;

AUTONOMIC PHARMACOLOGY

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Effects of Adrenergic, Cholinergic and Ganglionic Blockade on Acute Depressor Responses to Metformin in Spontaneously Hypertensive Rats
Martin S. Muntzel, Ayat Abe and Jørgen S. Petersen

Journal of Pharmacology and Experimental Therapeutics May 1997, 281 (2) 618-623;
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Evidence for Spare Nicotinic Acetylcholine Receptors and a β4 Subunit in Bovine Adrenal Chromaffin Cells: Studies using Bromoacetylcholine, Epibatidine, Cytisine and mAb35
Bryan W. Wenger, Darrell L. Bryant, R. Thomas Boyd and Dennis B. McKay

Journal of Pharmacology and Experimental Therapeutics May 1997, 281 (2) 905-913;

BEHAVIORAL PHARMACOLOGY

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Central Serotonergic Systems in the Spontaneously Hypertensive and Lewis Rat Strains that Differ in the Elevated Plus-Maze Test of Anxiety
Alexander Kulikov, Sylvie Aguerre, Olivier Berton, Andre Ramos, Pierre Mormede and Francis Chaouloff

Journal of Pharmacology and Experimental Therapeutics May 1997, 281 (2) 775-784;
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N-Methyl-d-Aspartate Receptors in Associative Eyeblink Conditioning: Both MK-801 and Phencyclidine Produce Task- and Dose-Dependent Impairments
Lucien T. Thompson and John F. Disterhoft

Journal of Pharmacology and Experimental Therapeutics May 1997, 281 (2) 928-940;

CARDIOVASCULAR PHARMACOLOGY

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The Peripheral Action of Clonidine Analog ST-91: Involvement of Atrial Natriuretic Factor
Jolanta Gutkowska, Suhayla Mukaddam-Daher and Johanne Tremblay

Journal of Pharmacology and Experimental Therapeutics May 1997, 281 (2) 670-676;
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Nonpeptide Glycoprotein IIb/IIIa Inhibitors. 15. Antithrombotic Efficacy of L-738,167, a Long-Acting GPIIb/IIIa Antagonist, Correlates with Inhibition of Adenosine Diphosphate-Induced Platelet Aggregation but not with Bleeding Time Prolongation
Jacquelynn J. Cook, Gary R. Sitko, Marie A. Holahan, Maria T. Stranieri, Joan D. Glass, Ben C. Askew, Charles J. McIntyre, David A. Claremon, John J. Baldwin, George D. Hartman, Robert J. Gould and Joseph J. Lynch

Journal of Pharmacology and Experimental Therapeutics May 1997, 281 (2) 677-689;
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RPR 107393, a Potent Squalene Synthase Inhibitor and Orally Effective Cholesterol-Lowering Agent: Comparison with Inhibitors of HMG-CoA Reductase
Dilip Amin, Ruth Z. Rutledge, Saul N. Needle, Helen F. Galczenski, Kent Neuenschwander, Anthony C. Scotese, Martin P. Maguire, Ray C. Bush, Dave J. Hele, Glenda E. Bilder and Mark H. Perrone

Journal of Pharmacology and Experimental Therapeutics May 1997, 281 (2) 746-752;

CELLULAR AND MOLECULAR PHARMACOLOGY

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Novel Cyclic Peptide Agonist of High Potency and Selectivity for the Type II Vasoactive Intestinal Peptide Receptor
Menghang Xia, Sunil P. Sreedharan, David R. Bolin, Gary O. Gaufo and Edward J. Goetzl

Journal of Pharmacology and Experimental Therapeutics May 1997, 281 (2) 629-633;
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Vasodilator Action of Calcium Antagonists in Coronary ArteriesIn Vitro
Stanley Kalsner

Journal of Pharmacology and Experimental Therapeutics May 1997, 281 (2) 634-642;
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Activation of the Metabotropic Glutamate Receptor mGluR5 Prevents Glutamate Toxicity in Primary Cultures of Cerebellar Neurons
Carmina Montoliu, Marta Llansola, Carmen Cucarella, Santiago Grisolía and Vicente Felipo

Journal of Pharmacology and Experimental Therapeutics May 1997, 281 (2) 643-647;
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Agonist-Independent Effect of an Allosteric Enhancer of the A₁ Adenosine Receptor in CHO Cells Stably Expressing the Recombinant Human A₁ Receptor
C. A. Kollias-Baker, J. Ruble, M. Jacobson, J. K. Harrison, M. Ozeck, J. C. Shryock and L. Belardinelli

Journal of Pharmacology and Experimental Therapeutics May 1997, 281 (2) 761-768;
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Effects of Cadmium and Nisoldipine on the Delayed Rectifier Potassium Current in Guinea Pig Ventricular Myocytes
Pascal Daleau, Majed Khalifa and Jacques Turgeon

Journal of Pharmacology and Experimental Therapeutics May 1997, 281 (2) 826-833;
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Amantadine Inhibits Nicotinic Acetylcholine Receptor Function in Hippocampal Neurons
Hiroaki Matsubayashi, Karen L. Swanson and Edson X. Albuquerque

Journal of Pharmacology and Experimental Therapeutics May 1997, 281 (2) 834-844;

DRUG METABOLISM AND DISPOSITION

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Studies on the Metabolic Activation of Disulfiram in Rat. Evidence for Electrophilic S-Oxygenated Metabolites as Inhibitors of Aldehyde Dehydrogenase and Precursors of UrinaryN-Acetylcysteine Conjugates
Pei Hu, Lixia Jin and Thomas A. Baillie

Journal of Pharmacology and Experimental Therapeutics May 1997, 281 (2) 611-617;
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Catalysis of the Cysteine Conjugation and Protein Binding of Acetaminophen by Microsomes from a Human Lymphoblast Line Transfected with the cDNAs of Various Forms of Human Cytochrome P450
Lingxiang Zhou, Richard R. Erickson, James P. Hardwick, Sang S. Park, Steven A. Wrighton and Jordan L. Holtzman

Journal of Pharmacology and Experimental Therapeutics May 1997, 281 (2) 785-790;
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Interindividual Variability in Expression and Activity of Human β-Glucuronidase in Liver and Kidney: Consequences for Drug Metabolism
Bernhard Sperker, Thomas E. Mürdter, Monika Schick, Klaus Eckhardt, Klaus Bosslet and Heyo K. Kroemer

Journal of Pharmacology and Experimental Therapeutics May 1997, 281 (2) 914-920;

GASTROINTESTINAL PHARMACOLOGY

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Increased Intestinal Absorption of Cefixime by Nifedipine in the Rat Intestinal Perfusion Model: Evidence for a Neural Regulation
L. Harcouët, D. Lebrec, C. Rozé, C. Carbon and R. Farinotti

Journal of Pharmacology and Experimental Therapeutics May 1997, 281 (2) 738-745;

IMMUNOPHARMACOLOGY

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Losartan, a Selective Inhibitor of Subtype AT1 Receptors for Angiotensin II, Inhibits the Binding ofN-Formylmethionyl-leucyl-phenylalanine to Neutrophil Receptors
Silvina Raiden, Mirta Giordano, Graciela Andonegui, Analía S. Trevani, Daniel H. López, Victor Nahmod and Jorge R. Geffner

Journal of Pharmacology and Experimental Therapeutics May 1997, 281 (2) 624-628;
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Cysteinyl Leukotrienes Induce P-Selectin Expression in Human Endothelial Cells via a Non-CysLT₁ Receptor-Mediated Mechanism
Karen E. Pedersen, Bruce S. Bochner and Bradley J. Undem

Journal of Pharmacology and Experimental Therapeutics May 1997, 281 (2) 655-662;
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A Peptidomimetic that Specifically Inhibits Human Leukocyte Antigen DRB1^*0401-restricted T Cell Proliferation
Susan L. Woulfe, Christine P. Bono, Michelle L. Zacheis, Joseph K. Welply, Dawn A. Kirschmann, Troy A. Baudino, Yang Wang, Deborah A. Stone, Gunnar J. Hanson, Jennifer L. Vuletich, Louis J. Bedell, Benjamin D. Schwartz and Susan C. Howard

Journal of Pharmacology and Experimental Therapeutics May 1997, 281 (2) 663-669;
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Activation of the Alternative Pathway of Complement by a Phosphorothioate Oligonucleotide: Potential Mechanism of Action
Scott P. Henry, Patricia C. Giclas, Janet Leeds, Michael Pangburn, Carol Auletta, Arthur A. Levin and Douglas J. Kornbrust

Journal of Pharmacology and Experimental Therapeutics May 1997, 281 (2) 810-816;
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Activation of Mu Opioid Receptors Inhibits Microglial Cell Chemotaxis
Chun C. Chao, Shuxian Hu, Katherine B. Shark, Wen S. Sheng, Genya Gekker and Phillip K. Peterson

Journal of Pharmacology and Experimental Therapeutics May 1997, 281 (2) 998-1004;

NEUROPHARMACOLOGY

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Hippocampal Noradrenaline Release in Awake, Freely Moving Rats Is Regulated by Alpha-2 Adrenoceptors but Not by Adenosine Receptors
Adrian J. Carter

Journal of Pharmacology and Experimental Therapeutics May 1997, 281 (2) 648-654;
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Receptor Reserve and Turnover of Alpha-2 Adrenoceptors that Mediate the Clonidine-Induced Inhibition of Rat Locus Coeruleus Neurons In Vivo
Joseba Pineda, J. Angel Ruiz-Ortega and Luisa Ugedo

Journal of Pharmacology and Experimental Therapeutics May 1997, 281 (2) 690-698;
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Increased Responsiveness of Ventral Tegmental Area Dopamine Neurons to Glutamate after Repeated Administration of Cocaine or Amphetamine Is Transient and Selectively Involves AMPA Receptors
Xu-Feng Zhang, Xiu-Ti Hu, Francis J. White and Marina E. Wolf

Journal of Pharmacology and Experimental Therapeutics May 1997, 281 (2) 699-706;
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Pharmacological Characterization of 1-Aminoindan-1,5-dicarboxylic Acid, a Potent mGluR1 Antagonist
Flavio Moroni, Grazia Lombardi, Christian Thomsen, Patrizia Leonardi, Sabina Attucci, Fiamma Peruginelli, Serenella Albani Torregrossa, Domenico E. Pellegrini-Giampietro, Roberto Luneia and Roberto Pellicciari

Journal of Pharmacology and Experimental Therapeutics May 1997, 281 (2) 721-729;
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γ-Hydroxybutyrate Conversion into GABA Induces Displacement of GABA_B Binding that is Blocked by Valproate and Ethosuximide
Viviane Hechler, Charline Ratomponirina and Michel Maitre

Journal of Pharmacology and Experimental Therapeutics May 1997, 281 (2) 753-760;
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Structure-Activity Relationships of a Series of [d-Ala²]Deltorphin I and II Analogues;in Vitro Blood-Brain Barrier Permeability and Stability
Sarah A. Thomas, Thomas J. Abbruscato, Vincent S. Hau, Terrence J. Gillespie, Joseph Zsigo, Victor J. Hruby and Thomas P. Davis

Journal of Pharmacology and Experimental Therapeutics May 1997, 281 (2) 817-825;
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Pyrrolopyrimidines: Novel Brain-Penetrating Antioxidants with Neuroprotective Activity in Brain Injury and Ischemia Models
E. D. Hall, P. K. Andrus, S. L. Smith, T. J. Fleck, H. M. Scherch, B. S. Lutzke, G. A. Sawada, J. S. Althaus, P. F. Vonvoigtlander, G. E. Padbury, P.G. Larson, J. R. Palmer and G. L. Bundy

Journal of Pharmacology and Experimental Therapeutics May 1997, 281 (2) 895-904;
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Effects of a Novel Free Radical Scavenger, MCI-186, on Ischemic Brain Damage in the Rat Distal Middle Cerebral Artery Occlusion Model
Hiroshi Kawai, Hiroshi Nakai, Misao Suga, Satoshi Yuki, Toshiaki Watanabe and Ken-Ichi Saito

Journal of Pharmacology and Experimental Therapeutics May 1997, 281 (2) 921-927;
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Age-Related Deficits in the Cerebellar BetaAdrenergic Signal Transduction Cascade in Fischer 344 Rats
Thomas J. Gould and Paula C. Bickford

Journal of Pharmacology and Experimental Therapeutics May 1997, 281 (2) 965-971;
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The Full D₁ Dopamine Receptor Agonist SKF-82958 Induces Neuropeptide mRNA in the Normosensitive Striatum of Rats: Regulation of D₁/D₂ Interactions by Muscarinic Receptors
John Q. Wang and Jacqueline F. McGinty

Journal of Pharmacology and Experimental Therapeutics May 1997, 281 (2) 972-982;
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HepG2 and SK-N-MC: Two Human Models to StudyAlpha-2 Adrenergic Receptors of theAlpha-2C Subtype
Stéphane Schaak, Cécile Cayla, Régis Blaise, Françoise Quinchon and Hervé Paris

Journal of Pharmacology and Experimental Therapeutics May 1997, 281 (2) 983-991;

PROSTAGLANDINS, LEUKOTRIENES AND OTHER EICOSANOIDS

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Endothelin Receptor Antagonists: Effect of Serum Albumin on Potency and Comparison of Pharmacological Characteristics
Jinshyun R. Wu-Wong, Douglas B. Dixon, William J. Chiou and Terry J. Opgenorth

Journal of Pharmacology and Experimental Therapeutics May 1997, 281 (2) 791-798;
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FP Prostaglandin Receptors Mediating Inositol Phosphates Generation and Calcium Mobilization in Swiss 3T3 Cells: A Pharmacological Study
B. W. Griffin, G. W. Williams, J. Y. Crider and N. A. Sharif

Journal of Pharmacology and Experimental Therapeutics May 1997, 281 (2) 845-854;
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Thrombin Receptor-Activating Peptide Releases Arachidonic Acid from Human Platelets: A Comparison with Thrombin and Trypsin
Archibald McNicol and Cameron A. Robson

Journal of Pharmacology and Experimental Therapeutics May 1997, 281 (2) 861-867;
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Effects of the 5-Lipoxygenase Inhibitor A-64077 on Intestinal Hypothermic Organ Preservation Injury
Martin J. Mangino, Janice E. Mangino, Bharat Kotadia and Marek Sielczak

Journal of Pharmacology and Experimental Therapeutics May 1997, 281 (2) 950-956;
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The Human Thromboxane A₂ Receptor α Isoform (TP_α) Functionally Couples to the G Proteins G_q and G₁₁ In Vivo and is Activated by the Isoprostane 8-epi Prostaglandin F_2α
B. Therese Kinsella, Daniel J. O’Mahony and Garret A. Fitzgerald

Journal of Pharmacology and Experimental Therapeutics May 1997, 281 (2) 957-964;
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Prostaglandin E₂ Production Dependent upon Cyclooxygenase-1 and Cyclooxygenase-2 and Its Contradictory Modulation by Auranofin in Rat Peritoneal Macrophages
Masateru Yamada, Hisae Niki, Masamichi Yamashita, Suetsugu Mue and Kazuo Ohuchi

Journal of Pharmacology and Experimental Therapeutics May 1997, 281 (2) 1005-1012;

TOXICOLOGY

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The Pyrethroids Permethrin and Cyhalothrin are Potent Inhibitors of the Mitochondrial Complex I
Beat Gassner, Andreas Wüthrich, Günter Scholtysik and Marc Solioz

Journal of Pharmacology and Experimental Therapeutics May 1997, 281 (2) 855-860;
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Expression of hyg^R in Transgenic Mice Causes Resistance to Toxic Effects of Hygromycin B In Vivo
Jiri Aubrecht, Mary E. P. Goad, Elizabeth M. Simpson and Robert H. Schiestl

Journal of Pharmacology and Experimental Therapeutics May 1997, 281 (2) 992-997;

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Table of Contents

ANALGESIA AND DRUGS OF ABUSE

AUTONOMIC PHARMACOLOGY

BEHAVIORAL PHARMACOLOGY

CARDIOVASCULAR PHARMACOLOGY

CELLULAR AND MOLECULAR PHARMACOLOGY

DRUG METABOLISM AND DISPOSITION

GASTROINTESTINAL PHARMACOLOGY

IMMUNOPHARMACOLOGY

NEUROPHARMACOLOGY

PROSTAGLANDINS, LEUKOTRIENES AND OTHER EICOSANOIDS

TOXICOLOGY

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