Abstract
1. A distribution study on rats with C14-methoxy-labeled radio-codeine indicated demethylation at the 3-position with the evolution of C*O2 in the expired air.
2. Codeine is excreted unchanged by the kidney and into the lumen of the gastro-intestinal tract.
3. The liver metabolizes codeine to a material with solubility characteristics different from codeine. This material is excreted into the duodenum via the biliary tract.
Footnotes
- Received October 30, 1950.
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