THE METABOLIC FATE OF ACETANILID AND OTHER ANILINE DERIVATIVES

I. MAJOR METABOLITES OF ACETANILID APPEARING IN THE URINE

¹ From the Laboratory of Applied Physiology, Yale University

1. The present theories of the metabolism of acetanilid in man are conflicting. As the first step toward clarification a quantitative study was made of the major metabolites appearing in the urine.

2. Seventy to 90 per cent of the acetanilid administered appeared in the urine as conjugated p-aminophenol.

3. There was no free p-aminophenol.

4. Of the total p-aminophenol excreted, as determined in one experiment, 4 per cent consisted of the N-acetyl conjugate and 96 per cent as an hydroxy conjugate. The major portion of N-acetyl-p-aminophenol was excreted in the first few hours after administration.

5. Conjugated aniline was excreted to the extent of 0.2 to 0.6 per cent of the amount of acetanilid administered and mainly during the first 4 hours.

6. There was no free aniline.

7. There was no 2-benzoxazolone.

8. Azo compounds appeared in the urine in an amount corresponding to about 0.5 per cent of the acetanilid administreed.

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