26 November 2008

Leon D Kluskens, Ad Nelemans, Rick Rink, Louwe de Vries, Anita Meter-Arkema, Yong Wang, Thomas Walther, Anneke Kuipers, Gert N Moll, and Marijke Haas

Angiotensin-(1-7) with thioether-bridge: an ACE-resistant, potent Ang-(1-7) analogue
Published November 26, 2008; doi: 10.1124/jpet.108.146431 [Abstract] [PDF] [Data Supplement]  

Sarah J. Farnsworth, Trent J. Volz, Glen R. Hanson, and Annette E. Fleckenstein

Cocaine Alters Vesicular Dopamine Sequestration and Potassium-Stimulated Dopamine Release: The Role of D2 Receptor Activation
Published November 26, 2008; doi: 10.1124/jpet.108.146159 [Abstract] [PDF]  

25 November 2008

Jin Ren, Zaichuan Mi, Nicolas A Stewart, and Edwin K Jackson

Identification and Quantification of 2',3'-cAMP Release by the Kidney
Published November 25, 2008; doi: 10.1124/jpet.108.146712 [Abstract] [PDF]  

Michael N. Ndengele, Salvatore Cuzzocrea, Emanuela Masini, Maria Cristina Vinci, Emanuela Esposito, Carolina Muscoli, Daniela Nicoleta Petrusca, Vincenzo Mollace, Emanuela Mazzon, Dechun Li, Irina Petrache, George M. Matuschak, and Daniela Salvemini

Spinal Ceramide Modulates the Development of Morphine Antinociceptive Tolerance via Peroxynitrite Mediated Nitroxidative Stress and Neuroimmune Activation
Published November 25, 2008; doi: 10.1124/jpet.108.146290 [Abstract] [PDF]  

Fan Jia, Peter A. Goldstein, and Neil L. Harrison

The Modulation of Synaptic GABA_A Receptors in the Thalamus by Eszopiclone and Zolpidem
Published November 25, 2008; doi: 10.1124/jpet.108.146084 [Abstract] [PDF]  

Xiangying Jiao, Erhe Gao, Yuexing Yuang, Yajing Wang, Wayne Lau, Walter Koch, Xinliang Ma, and Ling Tao

INO-4885, a Peroxynitrite Decomposition Catalyst, Protects the Heart against Reperfusion Injury in Mice
Published November 25, 2008; doi: 10.1124/jpet.108.144352 [Abstract] [PDF]  

24 November 2008

Kylie J Mansfield, Jonathan J Chandran, Kenneth J Vaux, Richard J Millard, Arthur Christopoulos, Fredrick J Mitchelson, and Elizabeth Burcher

Comparison of receptor binding characteristics of commonly used muscarinic antagonists in human bladder detrusor and mucosa
Published November 24, 2008; doi: 10.1124/jpet.108.145508 [Abstract] [PDF]  

21 November 2008

Ulla Seehusen Kruchov van Deurs, Niels Hadrup, Jorgen Soberg Petersen, Sten Christensen, and Thomas E. N. Jonassen

NOP receptor agonist ZP120 induces antinatriuresis in rats by stimulation of amiloride-sensitive sodium reabsorption
Published November 21, 2008; doi: 10.1124/jpet.108.144774 [Abstract] [PDF]  

20 November 2008

Weihong Ma, Hui Hui, Pablo Pelegrin, and Annmarie Surprenant

Pharmacological characterization of pannexin-1 currents expressed in mammalian cells
Published November 20, 2008; doi: 10.1124/jpet.108.146365 [Abstract] [PDF] [Data Supplement]  

Iris Hecht, Rong Jiang, Andre LF Sampaio, Chen Hermesh, Caleb Rutledge, Ronen Shemesh, Amir Toporik, Merav Beiman, Liat Dassa, Hagit Niv, Gady Cojocaru, Arie Zauberman, Galit Rotman, Mauro Perretti, Jakob Vinten-Johansen, and Yossi Cohen

A novel peptide agonist of FPRL1 (ALX) displays anti-inflammatory and cardioprotective effects
Published November 20, 2008; doi: 10.1124/jpet.108.145821 [Abstract] [PDF]  

Jerry J. Buccafusco, J Warren Beach, and Alvin V. Terry

Desensitization of nicotinic acetylcholine receptors as a strategy for drug development
Published November 20, 2008; doi: 10.1124/jpet.108.145292 [Abstract] [PDF]  

Roberta Baetta, Agnese Granata, Monica Canavesi, Nicola Ferri, Lorenzo Arnaboldi, Stefano Bellosta, Pascal Pfister, and Alberto Corsini

Everolimus inhibits monocyte/macrophage migration in vitro and their accumulation in carotid lesions of cholesterol-fed rabbits
Published November 20, 2008; doi: 10.1124/jpet.108.144147 [Abstract] [PDF]  

18 November 2008

Eric G Vajda, Francisco J. Lopez, Peter Rix, Robert Hill, Yanling Chen, Kyoung-Jin Lee, Zhihong O'Brien, William Y Chang, Martin D Meglasson, and Yong-Hee Lee

Pharmacokinetics and pharmacodynamics of LGD-3303, an orally available non-steroidal selective androgen receptor modulator (SARM)
Published November 18, 2008; doi: 10.1124/jpet.108.146811 [Abstract] [PDF]  

Thomas Storme, Alain Deroussent, Lionel Mercier, Elise Prost, Micheline Re, Fabienne Munier, Thierry Martens, Philippe Bourget, Gilles Vassal, Jacques Royer, and Angelo Paci

New ifosfamide analogues designed for lower associated neurotoxicity and nephrotoxicity with modified alkylating kinetics leading to enhanced in vitro anticancer activity
Published November 18, 2008; doi: 10.1124/jpet.108.144170 [Abstract] [PDF]  

14 November 2008

Paul H. Ratz and Amy S. Miner

Role of PKC and Calcium Entry in KCl-Induced Vascular Smooth Muscle Calcium Sensitization and Feed Back Control of Cellular Calcium Levels
Published November 14, 2008; doi: 10.1124/jpet.108.142422 [Abstract] [PDF]  

13 November 2008

Chun Xia Zhao, Xizhen Xu, Yinghua Cui, Peihua Wang, Xin Wei, Shilin Yang, Matthew L. Edin, Darryl C. Zeldin, and Dao Wen Wang

Increased Endothelial Nitric Oxide Synthase Expression Reduces Hypertension and Hyperinsulinemia in Fructose-treated Rats
Published November 13, 2008; doi: 10.1124/jpet.108.143396 [Abstract] [PDF]  

12 November 2008

Lauren Kent, Lucy Smyth, Jonathan Plumb, Chris Clayton, Steve Fox, David Ray, Stuart Farrow, and Dave Singh

Inhibition of LPS Stimulated COPD Macrophage Inflammatory Gene Expression by Dexamethasone and the p38 MAPK Inhibitor SB706504
Published November 12, 2008; doi: 10.1124/jpet.108.142950 [Abstract] [PDF] [Data Supplement]  

Kin-ya Ohta, Yuichiro Imamura, Noriko Okudaira, Ryou Atsumi, Katsuhisa Inoue, and Hiroaki Yuasa

Functional characterization of multidrug and toxin extrusion protein 1 as a facilitative transporter for fluoroquinolones
Published November 12, 2008; doi: 10.1124/jpet.108.142257 [Abstract] [PDF] [Data Supplement]  

10 November 2008

Takao Watanabe, Hiroyuki Kusuhara, Kazuya Maeda, Yoshihisa Shitara, and Yuichi Sugiyama

Physiologically Based Pharmacokinetic Modeling to Predict Transporter-Mediated Clearance and Distribution of Pravastatin in Humans
Published November 10, 2008; doi: 10.1124/jpet.108.146647 [Abstract] [PDF]  

Eduardo R. Butelman, Thomas E Prisinzano, Haiteng Deng, Szymon Rus, and Mary Jeanne Kreek

Unconditioned behavioral effects of the powerful -opioid hallucinogen, salvinorin A: Fast onset and entry into cerebrospinal fluid
Published November 10, 2008; doi: 10.1124/jpet.108.145342 [Abstract] [PDF]  

Mythili Yenjerla, Corey Cox, Leslie Wilson, and Mary Ann Jordan

Carbendazim inhibits cancer cell proliferation by suppressing microtubule dynamics
Published November 10, 2008; doi: 10.1124/jpet.108.143537 [Abstract] [PDF]  

7 November 2008

Nimesh S. A. Patel, Rosanna di Paola, Emanuela Mazzon, Domenico Britti, Christoph Thiemermann, and Salvatore Cuzzocrea

Peroxisome-proliferator activated receptor- contributes to the resolution of inflammation following renal ischemia/reperfusion injury
Published November 7, 2008; doi: 10.1124/jpet.108.146191 [Abstract] [PDF]  

Christopher Regan, Gary Stump, Stefanie Kane, and Joseph Lynch

CGRP Receptor Antagonism Does Not Affect the Severity of Myocardial Ischemia during Atrial Pacing in Dogs with Coronary Artery Stenosis
Published November 7, 2008; doi: 10.1124/jpet.108.144220 [Abstract] [PDF]  

Onkar Kulkarni, Dirk Eulberg, Norma Selve, Stephan Zollner, Ramanjaneyulu Allam, Rahul D Pawar, Stephanie Pfeiffer, Stephan Segerer, Sven Klussmann, and Hans-Joachim Anders

Anti-Ccl2 Spiegelmer permits 75% dose reduction of cyclophosphamide to control diffuse proliferative lupus nephritis and pneumonitis in MRL-Fas(lpr) mice
Published November 7, 2008; doi: 10.1124/jpet.108.142711 [Abstract] [PDF]  

6 November 2008

Michitaka Ogura, Shigeru Nishida, Michiyasu Ishizawa, Kenichi Sakurai, Makoto Shimizu, Sadanori Matsuo, Sadao Amano, Shigeyuki Uno, and Makoto Makishima

Vitamin D₃ Modulates the Expression of Bile Acid Regulatory Genes and Represses Inflammation in Bile Duct-Ligated Mice
Published November 6, 2008; doi: 10.1124/jpet.108.145987 [Abstract] [PDF]  

Panagiota Zania, Despina Gourni, Alfred C. Aplin, Roberto F. Nicosia, Christodoulos S. Flordellis, Michael E. Maragoudakis, and Nikos E. Tsopanoglou

Parstatin, the cleaved peptide on proteinase-activated receptor 1 activation, is a potent inhibitor of angiogenesis
Published November 6, 2008; doi: 10.1124/jpet.108.145664 [Abstract] [PDF]  

5 November 2008

Elie Simard, Denan Jin, Shinji Takai, Mizuo Miyazaki, Isabelle Brochu, and Pedro D'Orleans-Juste

CHYMASE-DEPENDENT CONVERSION OF BIG ENDOTHELIN-1 IN THE MOUSE IN VIVO
Published November 5, 2008; doi: 10.1124/jpet.108.142992 [Abstract] [PDF]  

4 November 2008

Mary Chebib, Tina Hinton, Katrina L Schmid, Darren Brinkworth, Haohua Qian, Susana Matos, Hye-Lim Kim, Heba Abdel-Halim, Rohan J Kumar, Graham A R Johnston, and Jane R Hanrahan

Novel, potent and selective GABA_C antagonists inhibit myopia development and facilitate learning and memory
Published November 4, 2008; doi: 10.1124/jpet.108.146464 [Abstract] [PDF]  

Soyong Jang, Jae-Chul Jung, Dong Hyun Kim, Jong Hoon Ryu, Yongnam Lee, Mankil Jung, and Seikwan Oh

The neuroprotective effects of benzylideneacetophenone derivatives on excitotoxicity and inflammation via pJAK2/pSTAT3 and MAPK pathways
Published November 4, 2008; doi: 10.1124/jpet.108.144014 [Abstract] [PDF]  

William P. Fawcett, Yasco Aracava, Michael Adler, Edna F. R. Pereira, and Edson X. Albuquerque

Acute toxicity of organophosphorus compounds in guinea pigs is sex and age dependent and cannot be solely accounted for by acetylcholinesterase inhibition
Published November 4, 2008; doi: 10.1124/jpet.108.146639 [Abstract] [PDF]  

Stephanie Dal-Ros, Christian Bronner, Christa Schott, Modou O. Kane, Marta Chataigneau, Valerie B. Schini-Kerth, and Thierry Chataigneau

Angiotensin II-induced hypertension is associated with a selective inhibition of EDHF-mediated responses in the rat mesenteric artery
Published November 4, 2008; doi: 10.1124/jpet.108.145326 [Abstract] [PDF]  

Tatiana F. Gonzalez-Cestari, Brandon J. Henderson, Ryan E. Pavlovicz, Susan B. McKay, Raed A. El-Hajj, Aravinda B. Pulipaka, Crina M. Orac, Damon D. Reed, R Thomas Boyd, Michael X. Zhu, Chenglong Li, Stephen C. Bergmeier, and Dennis B. McKay

Effect of Novel Negative Allosteric Modulators of Neuronal Nicotinic Receptors on Cells Expressing Native and Recombinant Nicotinic Receptors: Implications for Drug Discovery
Published November 4, 2008; doi: 10.1124/jpet.108.144576 [Abstract] [PDF]  

3 November 2008

Sharanya Vemula, Karen Roder, Tianzhi Yang, G. Jayarama Bhat, Thomas J. Thekkumkara, and Thomas J. Abbruscato

A functional role for sodium dependent glucose transport across the blood-brain barrier during oxygen glucose deprivation
Published November 3, 2008; doi: 10.1124/jpet.108.146589 [Abstract] [PDF]  

Hiroki Mori, Hiroko Tonai-Kachi, Yasuo Ochi, Yasuhito Taniguchi, Hiroyuki Ohshiro, Nobuyuki Takahashi, Takeshi Aihara, Akiko Hirao, Teruhisa Kato, Minoru Sakakibara, and Yoichi Kurebayashi

PF-03716556, a novel, potent, and selective acid pump antagonist for the treatment of gastro-esophageal reflux disease
Published November 3, 2008; doi: 10.1124/jpet.108.146415 [Abstract] [PDF]  

Rengasamy RM Maran, Ann Thomas, Magen Roth, Zhonghua Shen, Noriko Esterly, David Pinson, Xin Gao, Yawei Zhang, Vadivel Ganapathy, Frank Gonzalez, and Grace L Guo

FXR Deficiency in Mice Leads to Increased Intestinal Epithelial Cell Proliferation and Tumor Development
Published November 3, 2008; doi: 10.1124/jpet.108.145409 [Abstract] [PDF] [Data Supplement]  

30 October 2008

Edward Perez-Reyes, Amy L. Van Deusen, and Iuliia Vitko

Molecular pharmacology of human Ca_v3.2 T-type Ca²⁺ channels: Block by antihypertensives, antiarrhythmics, and their analogs
Published October 30, 2008; doi: 10.1124/jpet.108.145672 [Abstract] [PDF]  

Hye-Lim Noh, Yunying Hu, Tae-sik Park, Thomas DiCioccio, Andrew J. Nichols, Kazue Okajima, Shunichi Homma, and Ira J. Goldberg

Regulation of plasma fructose and mortality in mice by the aldose reductase inhibitor lidorestat
Published October 30, 2008; doi: 10.1124/jpet.108.136283 [Abstract] [PDF]  

29 October 2008

Cornelia B. Landersdorfer, Debra C. DuBois, Richard R. Almon, and William J. Jusko

Mechanism-Based Modeling of Nutritional and Leptin Influences on Growth in Normal and Type 2 Diabetic Rats
Published October 29, 2008; doi: 10.1124/jpet.108.144766 [Abstract] [PDF]  

Leo Thomas, Moh Tadayyon, and Michael Mark

Chronic Treatment with the Dipeptidyl Peptidase-4 Inhibitor (R)-8-(3-Amino-piperidin-1-yl)-7-but-2-ynyl-3-methyl-1-(4-methyl-quinazolin-2-ylmethyl)-3,7-dihydro-purine-2,6-dione (BI 1356) Increases Basal Glucagon-Like Peptide-1 and Improves Glycemic Control in Diabetic Rodent Models
Published October 29, 2008; doi: 10.1124/jpet.108.143966 [Abstract] [PDF]  

Valeria Camarda, Anna Rizzi, Chiara Ruzza, Silvia Zucchini, Giuliano Marzola, Erika Marzola, Remo Guerrini, Severo Salvadori, Rainer R Reinscheid, Domenico Regoli, and Girolamo Calo'

In vitro and in vivo pharmacological characterization of the neuropeptide S receptor antagonist [D-Cys(tBu)⁵]NPS
Published October 29, 2008; doi: 10.1124/jpet.108.143867 [Abstract] [PDF]  

28 October 2008

Nikolai B. Fedorov, Lisa C. Benson, John Graef, Patrick M. Lippiello, and Merouane Bencherif

DIFFERENTIAL PHARMACOLOGIES OF MECAMYLAMINE ENANTIOMERS: POSITIVE ALLOSTERIC MODULATION AND NON-COMPETITIVE INHIBITION
Published October 28, 2008; doi: 10.1124/jpet.108.146910 [Abstract] [PDF]  

Johanna J. Bogulavsky, Ann M. Gregus, Paul T-H. Kim, Alberto C.S. Costa, Anjali M. Rajadhyaksha, and Charles E. Inturrisi

Deletion of the GluR5 subunit of kainate receptors affects the development of morphine tolerance
Published October 28, 2008; doi: 10.1124/jpet.108.144121 [Abstract] [PDF]  

27 October 2008

Jennifer M Hughes, Oliver Wirth, Kristine Krajnak, Roger Miller, Sheila Flavahan, Dan E Berkowitz, Dan Welcome, and Nicholas Flavahan

INCREASED OXIDANT ACTIVITY MEDIATES VASCULAR DYSFUNCTION IN VIBRATION INJURY
Published October 27, 2008; doi: 10.1124/jpet.108.144618 [Abstract] [PDF]  

Naomi Visanji, Tom H. Johnston, Susan H. Fox, Mark J. Millan, and Jonathan M. Brotchie

₁-Adrenoceptors mediate L-DOPA-induced activity in MPTP-lesioned macaques
Published October 27, 2008; doi: 10.1124/jpet.108.144097 [Abstract] [PDF]  

24 October 2008

Lampson M Fan, David Sawbridge, Vinoj George, Lei Teng, Alexis Bailey, Ian Kitchen, and Jian-Mei Li

Chronic cocaine-induced cardiac oxidative stress and MAPK activation: The role of Nox2 oxidase
Published October 24, 2008; doi: 10.1124/jpet.108.145201 [Abstract] [PDF]  

Paulianda J Jones, Ellen C Merrick, Timothy W Batts, Nicholas J Hargus, Yuesheng Wang, James P Stables, Edward H Bertram, Milton L Brown, and Manoj K Patel

Modulation of sodium channel inactivation gating by a novel lactam: Implications for seizure suppression in chronic limbic epilepsy
Published October 24, 2008; doi: 10.1124/jpet.108.144709 [Abstract] [PDF]  

Jane Shearer, David L Severson, Lin Su, Luiz Belardinelli, and Arvinder Dhalla

PARTIAL A1 ADENOSINE RECEPTOR AGONIST REGULATES CARDIAC SUBSTRATE UTILIZATION IN INSULIN RESISTANT RATS IN VIVO
Published October 24, 2008; doi: 10.1124/jpet.108.143594 [Abstract] [PDF]  

23 October 2008

Bo Kong, James P Luyendyk, Ossama Tawfik, and Grace L Guo

FXR-deficiency Induces Non-alcoholic Steatohepatitis in LDLr-knockout Mice Fed a High-fat Diet
Published October 23, 2008; doi: 10.1124/jpet.108.144600 [Abstract] [PDF]  

Sunwoo Park, Glen E. P. Ropella, Sean H. K. Kim, Michael S. Roberts, and C. Anthony Hunt

Computational Strategies Unravel and Trace How Liver Disease Changes Hepatic Drug Disposition
Published October 23, 2008; doi: 10.1124/jpet.108.142497 [Abstract] [PDF] [Data Supplement]  

Daryl C Drummond, Charles O Noble, Zexiong Guo, Mark Hayes, John W Park, Ching-Ju Ou, Yun-Long Tseng, Keelung Hong, and Dmitri B Kirpotin

Improved Pharmacokinetics and Efficacy of a Highly Stable Nanoliposomal Vinorelbine
Published October 23, 2008; doi: 10.1124/jpet.108.141200 [Abstract] [PDF]  

Viviana Trezza and Louk Vanderschuren

Divergent Effects of Anandamide Transporter Inhibitors With Different Target Selectivity on Social Play Behavior in Adolescent Rats
Published October 23, 2008; doi: 10.1124/jpet.108.141069 [Abstract] [PDF]  

22 October 2008

Shyeilla V. Dhuria, Leah R. Hanson, and William H. Frey

Novel vasoconstrictor formulation to enhance intranasal targeting of neuropeptide therapeutics to the central nervous system
Published October 22, 2008; doi: 10.1124/jpet.108.145565 [Abstract] [PDF]  

21 October 2008

Kamakshi Sachidanandam, Jimmie R. Hutchinson, Mostafa M. Elgebaly, Erin M. Mezzetti, Mong-Heng Wang, and Adviye Ergul

Differential Effects of Diet-Induced Dyslipidemia and Hyperglycemia on Mesenteric Resistance Artery Structure and Function in Type 2 Diabetes
Published October 21, 2008; doi: 10.1124/jpet.108.142612 [Abstract] [PDF]  

17 October 2008

Betty B Yao, Gin Hsieh, Anthony Daza, Yihong Fan, George Grayson, Tiffany Garrison, Odile El Kouhen, Bradley Hooker, Madhavi Pai, Erica Wensink, Anita Salyers, Prasant Chandran, Chang Zhu, Chengmin Zhong, Keith Ryther, Megan Gallagher, Chih-liang Chin, Ann Tovcimak, Vincent Hradil, Gerard Fox, Michael Dart, Prisca Honore, and Michael Meyer

Characterization of a Cannabinoid CB₂ Receptor Selective Agonist, A-836339, in In Vitro Pharmacological assays and In Vivo Pain Models
Published October 17, 2008; doi: 10.1124/jpet.108.145011 [Abstract] [PDF]  

16 October 2008

TOMOAKI ISHIHARA, KEN-ICHIRO TANAKA, YUICHI TASAKA, TAKUSHI NAMBA, JUN SUZUKI, TSUTOMU ISHIHARA, SUSUMU OKAMOTO, TOSHIFUMI HIBI, MITSUKO TAKENAGA, RIE IGARASHI, KEIZO SATO, YUTAKA MIZUSHIMA, and Tohru Mizushima

Therapeutic effect of lecithinized superoxide dismutase (PC-SOD) against colitis
Published October 16, 2008; doi: 10.1124/jpet.108.144451 [Abstract] [PDF]  

Kazuhiko Seya, Kouta Kanemaru, Chiharu Sugimoto, Megumi Suzuki, Teruko Takeo, Shigeru Motomura, Haruo Kitahara, Masatake Niwa, Yoshiteru Oshima, and Ken-Ichi Furukawa

Opposite effects of two resveratrol tetramers, vitisin A and hopeaphenol on apoptosis of myocytes isolated from adult rat heart
Published October 16, 2008; doi: 10.1124/jpet.108.143172 [Abstract] [PDF]  

15 October 2008

Grzegorz Godlewski, Laszlo Offertaler, Douglas Osei-Hyiaman, Fong M Mo, Judith Harvey-White, Jie Liu, Margaret I Davis, Li Zhang, Raj K Razdan, Garry Milman, Pal Pacher, Partha Mukhopadhyay, David M Lovinger, and George Kunos

The endogenous brain constituent N-arachidonoyl L-serine is an activator of large conductance Ca²⁺-activated K⁺ channels
Published October 15, 2008; doi: 10.1124/jpet.108.144717 [Abstract] [PDF]  

14 October 2008

Sethu Sankaranarayanan, Marie A. Holahan, Dennis Colussi, Ming-Chih Crouthamel, Viswanath Devanarayan, Joan Ellis, Amy Espeseth, Adam T. Gates, Samuel L. Graham, Allison R. Gregro, Daria Hazuda, Jerome H. Hochman, Katharine Holloway, Lixia Jin, Jason Kahana, Ming-tain Lai, Janet Lineberger, Georgia McGaughey, Keith P. Moore, Philippe Nantermet, Beth Pietrak, Eric A. Price, Hemaka Rajapakse, Shaun Stauffer, Melissa A. Steinbeiser, Guy Seabrook, Harold G. Selnick, Xiao-Ping Shi, Matthew G. Stanton, John Swestock, Katherine Tugusheva, Keala X. Tyler, Joseph P. Vacca, Jacky Wong, Guoxin Wu, Min Xu, Jacquelynn J. Cook, and Adam J. Simon

First demonstration of CSF and plasma A lowering with oral administration of a BACE1 inhibitor in nonhuman primates
Published October 14, 2008; doi: 10.1124/jpet.108.143628 [Abstract] [PDF] [Data Supplement]  

Maeng-Hee Kang-Park, Brigitte L. Kieffer, Amanda J. Roberts, Marisa Roberto, Sam Madamba, George Robert Siggins, and Scott D. Moore

Mu opioid receptors selectively regulate basal inhibitory transmission in the central amygdala: lack of ethanol interactions
Published October 14, 2008; doi: 10.1124/jpet.108.140749 [Abstract] [PDF]  

10 October 2008

Noha N. Nassar and Abdel A. Abdel-Rahman

Brainstem Adenosine A₁ Receptor Signaling Masks Phosphorylated ERK1/2 Dependent Hypotensive Action of Clonidine in Conscious Normotensive Rats
Published October 10, 2008; doi: 10.1124/jpet.108.143883 [Abstract] [PDF]  

Laxminarayan G. Hegde, Xiao Li Ping, Nina Jochnowitz, and Douglas A. Craig

The role of melanin-concentrating hormone-1 (MCH₁) receptors in the voiding reflex in rats
Published October 10, 2008; doi: 10.1124/jpet.108.143495 [Abstract] [PDF]  

Spencer Snyder Ericksen, David F. Cummings, Harel Weinstein, and John A. Schetz

Ligand selectivity of D₂ dopamine receptors is modulated by changes in local dynamics produced by sodium binding
Published October 10, 2008; doi: 10.1124/jpet.108.141531 [Abstract] [PDF]  

Stephan Steidl and John S Yeomans

M₅ muscarinic receptor knockout mice show reduced morphine-induced locomotion, but increased locomotion following cholinergic antagonism in the ventral tegmental area
Published October 10, 2008; doi: 10.1124/jpet.108.144824 [Abstract] [PDF]  

Edwin T. Parlevliet, Janny P. Schroder-van der Elst, Eleonora P.M. Corssmit, Kristen Picha, Karyn O'Neil, Vedrana Stojanovic-Susulic, Tatiana Ort, Louis M. Havekes, Johannes A. Romijn, and Hanno Pijl

CNTO736, a Novel GLP-1 Receptor Agonist, Ameliorates Insulin Resistance and Inhibits Very Low Density Lipoprotein Production in High-Fat-Fed Mice
Published October 10, 2008; doi: 10.1124/jpet.108.144154 [Abstract] [PDF]  

8 October 2008

Manickavasagom Alkondon, Yasco Aracava, Edna R Pereira, and Edson X. Albuquerque

A single in vivo application of cholinesterase inhibitors has neuron type-specific effects on nicotinic receptor activity in guinea pig hippocampus
Published October 8, 2008; doi: 10.1124/jpet.108.146068 [Abstract] [PDF]  

Kenji Ikemura, Kimihiko Urano, Hiroko Matsuda, Hideki Mizutani, Takuya Iwamoto, and Masahiro OKUDA

Decreased oral absorption of cyclosporine A after liver ischemia-reperfusion injury in rats: The contribution of CYP3A and P-glycoprotein to the first-pass metabolism in intestinal epithelial cells
Published October 8, 2008; doi: 10.1124/jpet.108.145581 [Abstract] [PDF]  

Mei-Chuan Ko and Stephen M Husbands

Effects of Atypical Kappa Opioid Receptor Agonists on Intrathecal Morphine-Induced Itch and Analgesia in Primates
Published October 8, 2008; doi: 10.1124/jpet.108.143925 [Abstract] [PDF]  

7 October 2008

Alejandra M. Pacchioni, Joseph Vallone, Paul Worley, and Peter W. Kalivas

Neuronal pentraxins modulate cocaine-induced neuroadaptations
Published October 7, 2008; doi: 10.1124/jpet.108.143115 [Abstract] [PDF] [Data Supplement]  

3 October 2008

David J Behm, Andrea Ogbonna, Charlene Wu, Cynthia L Burns-Kurtis, and Stephen A Douglas

Epoxyeicosatrienoic Acids Function as Selective, Endogenous Antagonists of Native Thromboxane Receptors: Identification of a Novel Mechanism of Vasodilation
Published October 3, 2008; doi: 10.1124/jpet.108.145102 [Abstract] [PDF]  

Kwang-Seok Oh, Sunkyung Lee, Kyu Yang Yi, Ho Won Seo, Hyun-Na Koo, and Byung Ho Lee

A novel and orally active poly (ADP-ribose) polymerase-1 inhibitor, 2-[methoxycarbonyl(4-methoxyphenyl)methyl sulfanyl]-1H-benzimidazole-4-carboxylic acid amide (KR-33889), attenuates injury in in vitro model of cell death and in vivo model of cardiac ischemia
Published October 3, 2008; doi: 10.1124/jpet.108.143719 [Abstract] [PDF] [Data Supplement]  

2 October 2008

Andrea Cignarella, Chiara Bolego, Valeria Pelosi, Clara Meda, Andree Krust, Christian Pinna, Rosa Maria Gaion, Elisabetta Vegeto, and Adriana Maggi

Distinct roles of estrogen receptor- and in the modulation of vascular inducible NO synthase in diabetes
Published October 2, 2008; doi: 10.1124/jpet.108.143511 [Abstract] [PDF]  

Makoto Furonaka, Noboru Hattori, Takuya Tanimoto, Tadashi Senoo, Nobuhisa Ishikawa, Kazunori Fujitaka, Yoshinori Haruta, Akihito Yokoyama, and Nobuoki Kohno

Suplatast tosilate prevents bleomycin-induced pulmonary fibrosis in mice
Published October 2, 2008; doi: 10.1124/jpet.108.141721 [Abstract] [PDF]  

1 October 2008

Isamu Yamaguchi, Kentaro Hamada, Masanori Yoshida, Hiroyuki Isayama, Shuichi Kanazashi, and Koji Takeuchi

Risperidone attenuates local as well as systemic inflammatory responses to ameliorate diet-induced severe necrotic pancreatitis in mice: it may provide a new therapy for acute pancreatitis
Published October 1, 2008; doi: 10.1124/jpet.108.141895 [Abstract] [PDF]  

30 September 2008

Timo Weiland, Markus Weiller, Gerald Kunstle, and Albrecht Wendel

Sensitization by 5-Azacytidine towards death receptor-induced hepatic apoptosis
Published September 30, 2008; doi: 10.1124/jpet.108.143560 [Abstract] [PDF]  

29 September 2008

Katherine W Figueroa, Michael T Griffin, and Frederick J. Ehlert

Selectivity of Agonists for the Active State of M₁ - M₄ Muscarinic Receptor Subtypes
Published September 29, 2008; doi: 10.1124/jpet.108.145219 [Abstract] [PDF]  

26 September 2008

Patrick J Shaw, Patricia E Ganey, and Robert A Roth

TNF is a proximal mediator of synergistic hepatotoxicity from trovafloxacin/lipopolysaccharide coexposure
Published September 26, 2008; doi: 10.1124/jpet.108.143792 [Abstract] [PDF]  

Charlotte Hougaard, Matthew O. Fraser, China Chien, Angela Bookout, Mary Katofiasc, Bo S. Jensen, Frederik Rode, Jens B. Norhave, Lene Teuber, Karl B. Thor, Dorte Strobaek, Edward C. Burgard, and Lars Ronn

A Positive Modulator of K_Ca2 and K_Ca3 Channels, NS4591, Inhibits Bladder Afferent Firing in vitro and Bladder Overactivity in vivo
Published September 26, 2008; doi: 10.1124/jpet.108.143123 [Abstract] [PDF]  

Melinda Wuest, Birgit Eichhorn, Marc O. Grimm, Manfred P. Wirth, Ursula Ravens, and Alberto J Kaumann

Catecholamines relax detrusor through ₂-adrenoceptors in mouse and ₃-adrenoceptors in man
Published September 26, 2008; doi: 10.1124/jpet.108.142562 [Abstract] [PDF]  

25 September 2008

Ana B Garcia-Redondo, Ana M Briones, Amada E Beltran, Maria J Alonso, Ulf Simonsen, and Mercedes Salaices

Hypertension increases contractile responses to hydrogen peroxide in resistance arteries through increased TXA₂, Ca²⁺ and O₂^.- levels
Published September 25, 2008; doi: 10.1124/jpet.108.144295 [Abstract] [PDF]  

12 September 2008

Miriam Huls, Frans G.M. Russel, and Rosalinde Masereeuw

The role of ABC transporters in tissue defense and organ regeneration
Published September 12, 2008; doi: 10.1124/jpet.107.132225 [Abstract] [PDF]  

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