10 July 2009

Mark S. Swingle, Lauren Amable, Brian G. Lawhorn, Suzanne B. Buck, Christopher P. Burke, Pukar Ratti, Kimberly L. Fischer, Dale L. Boger, and Richard E. Honkanen

Structure-Activity Relationship Studies of Fostriecin, Cytostatin and Key Analogues, with PP1, PP2A, PP5, and (12-13)-chimeras (PP1/PP2A and PP5/PP2A) Provide Further Insight Into Inhibitory Actions of Fostriecin Family Inhibitors
Published July 10, 2009; doi: 10.1124/jpet.109.155630 [Abstract] [PDF]  

Samir Haj-Dahmane and Roh-Yu Shen

Endocannabinoids Suppress Excitatory Synaptic Transmission to Dorsal Raphe Serotonin Neurons through the Activation of Presynaptic CB₁ Receptors
Published July 10, 2009; doi: 10.1124/jpet.109.153858 [Abstract] [PDF]  

Sara M. Camp, Robert Bittman, Eddie T. Chiang, Liliana Moreno-Vinasco, Tamara Mirzapoiazova, Saad Sammani, Xuequan Lu, Chaode Sun, Mark Harbeck, Michael Roe, Viswanathan Natarajan, Joe G.N. Garcia, and Steven M. Dudek

Synthetic analogues of FTY720 differentially regulate pulmonary vascular permeability in vivo and in vitro
Published July 10, 2009; doi: 10.1124/jpet.109.153544 [Abstract] [PDF]  

9 July 2009

Julian Albarran, Ralf Gilsbach, Roland Piekorz, Katrin Pexa, Nadine Beetz, Johanna Schneider, Bernd Nuernberg, and Lutz Hein

Modulation of ₂-adrenoceptor functions by heterotrimeric G_i protein isoforms
Published July 9, 2009; doi: 10.1124/jpet.109.157230 [Abstract] [PDF]  

8 July 2009

Hiroyuki Mizoguchi, Kazuhiro Takuma, Emiko Fukuzaki, Daisuke Ibi, Eiichi Someya, Ko-hei Akazawa, Tursun Alkam, Hiroko Tsunekawa, Akihiro Mouri, Yukihiro Noda, Toshitaka Nabeshima, and Kiyofumi Yamada

Matrix metalloprotease-9 inhibition improves amyloid -mediated cognitive impairment and neurotoxicity in mice
Published July 8, 2009; doi: 10.1124/jpet.109.154724 [Abstract] [PDF] [Data Supplement]  

Vardan T Karamyan, Rama Gadepalli, John Rimoldi, and Robert Speth

Brain AT₁ angiotensin receptor subtype binding: Importance of peptidase inhibition for identification of angiotensin II as an endogenous ligand
Published July 8, 2009; doi: 10.1124/jpet.109.157461 [Abstract] [PDF]  

Ismayil Ahmet, Chris Morrell, Edward G. Lakatta, and Mark I Talan

Therapeutic Efficacy of a Combination of a 1 AR Blocker and 2 AR Agonist in a Rat Model of Post-Myocardial Infarction Dilated Heart Failure Exceeds that of a 1 AR Blocker plus ACE Inhibitor
Published July 8, 2009; doi: 10.1124/jpet.109.157107 [Abstract] [PDF] [Data Supplement]  

Bernard Fromenty, Nathalie Vadrot, Julie Massart, Bruno Turlin, Nadege Barri-Ova, Philippe Letteron, Alain Fautrel, and Marie-Anne Robin

Chronic ethanol consumption lessens the gain of body weight, liver triglycerides and diabetes in obese ob/ob mice
Published July 8, 2009; doi: 10.1124/jpet.109.155168 [Abstract] [PDF]  

7 July 2009

Martin Leduc, Billy Breton, Celine Gales, Christian Le Gouill, Michel Bouvier, Sylvain Chemtob, and Nikolaus Heveker

Functional selectivity of natural and synthetic prostaglandin EP₄ receptor ligands
Published July 7, 2009; doi: 10.1124/jpet.109.156398 [Abstract] [PDF] [Data Supplement]  

Sara Rafferty, Nicole Alcolado, Caroline Norez, Frederic Chappe, Siegried Pelzer, Frederic Becq, and Valerie Chappe

Rescue of functional F508del-CFTR by VIP in the human nasal epithelial cell line JME/CF15
Published July 7, 2009; doi: 10.1124/jpet.109.155341 [Abstract] [PDF]  

1 July 2009

Kazuhiro Kubo, Koichi Nishikawa, Junko Ishizeki, Makiko Hardy-Yamada, Yuchio Yanagawa, and Shigeru Saito

Thermal hyperalgesia via supraspinal mechanisms in mice lacking glutamate decarboxylase (GAD) 65
Published July 1, 2009; doi: 10.1124/jpet.109.156034 [Abstract] [PDF]  

30 June 2009

HIDENORI WAKE, HIDEO K TAKAHASHI, SHUJI MORI, KEYUE LIU, TADASHI YOSHINO, and MASAHIRO NISHIBORI

Histamine inhibits advanced glycation end products-induced adhesion molecule expression on human monocytes
Published June 30, 2009; doi: 10.1124/jpet.109.155960 [Abstract] [PDF]  

Pilar Almela, Noemi M Atucha, M. Victoria Milanes, and Maria Luisa Laorden

Crosstalk between PKA and MAP kinases signalling in the adaptive changes observed during morphine withdrawal in the heart
Published June 30, 2009; doi: 10.1124/jpet.109.154583 [Abstract] [PDF]  

29 June 2009

Wouter Koek, Susan L. Mercer, Andrew Coop, and Charles P. France

Behavioral effects of GHB, its precursor GBL, and GABA_B receptor agonists: time course, and differential antagonism by the GABA_B receptor antagonist CGP35348
Published June 29, 2009; doi: 10.1124/jpet.109.151845 [Abstract] [PDF]  

26 June 2009

Fabiana N Dornelles, Diogenes S Santos, Thomas E Van Dyke, Joao B Calixto, Eraldo L Batista, and Maria M Campos

In vivo up-regulation of kinin B₁ receptors following treatment with P. gingivalis LPS in rat paw
Published June 26, 2009; doi: 10.1124/jpet.109.155762 [Abstract] [PDF]  

25 June 2009

Mark W Musch, Donna L Arvans, Herve Paris, and Eugene Chang

Alpha2-adrenergic receptors attenuate secretagogue-induced endocytosis and promote exocytosis of intestinal NHE2 and NHE3
Published June 25, 2009; doi: 10.1124/jpet.109.151910 [Abstract] [PDF]  

Keiji Nishiyama, Yasushi Shintani, Keisuke Hirai, and Shin-ichi Yoshikubo

Molecular Cloning and Pharmacological Characterization of Monkey MT₁ and MT₂ Melatonin Receptors Showing High Affinity for the Agonist Ramelteon
Published June 25, 2009; doi: 10.1124/jpet.109.155283 [Abstract] [PDF]  

Robert N Willette, Marianne E. Eybye, Alan R. Olzinski, David J. Behm, Nambi Aiyar, Kristeen Maniscalco, Ross G. Bentley, Robert W. Coatney, Shufang Zhao, Timothy Westfall, and Chris P. Doe

Differential Effects of p38 MAPK and COX2 Inhibitors in a Model of Cardiovascular Disease
Published June 25, 2009; doi: 10.1124/jpet.109.154443 [Abstract] [PDF] [Data Supplement]  

23 June 2009

Tzu-Ching Kuo, Jai-Sing Yang, Meng-Wei Lin, Shu-Chun Hsu, Jen-Jyh Lin, Hui-Ju Lin, Te-Chun Hsia, Ching-Lung Liao, Mei-Due Yang, Ming-Jen Fan, W. G. Wood, and Jing-Gung Chung

Emodin has cytotoxic and protective effects in Rat C6 glioma cells: Roles of Mdr1a and NF-kappa B in cell survival
Published June 23, 2009; doi: 10.1124/jpet.109.153007 [Abstract] [PDF] [Data Supplement]  

22 June 2009

Fabrice Vandeput, Judith Krall, Ramzi Ockaili, Fadi N Salloum, Vincent Florio, Jackie D. Corbin, Sharron H Francis, Rakesh C. Kukreja, and Matthew A. Movsesian

cGMP-hydrolytic activity and its inhibition by sildenafil in normal and failing human and mouse myocardium
Published June 22, 2009; doi: 10.1124/jpet.109.154468 [Abstract] [PDF]  

18 June 2009

Anna Stadnicka, Stephen J Contney, Carol Moreno, Dorothee Weihrauch, Zeljko J Bosnjak, Richard J Roman, and Thomas A Stekiel

Mechanism of differential cardiovascular response to propofol in Dahl salt-sensitive (SS), Brown Norway (BN) and chromosome 13 substituted consomic rat strains: role of large conductance Ca²⁺ and voltage activated potassium (BK) channels
Published June 18, 2009; doi: 10.1124/jpet.109.154104 [Abstract] [PDF]  

Jannike Morch Andersen, Ase Ripel, Fernando Boix, Per Trygve Normann, and Jorg Morland

Increased locomotor activity induced by heroin in mice: Pharmacokinetic demonstration of heroin acting as a pro-drug for the mediator, 6-monoacetylmorphine, in vivo
Published June 18, 2009; doi: 10.1124/jpet.109.152462 [Abstract] [PDF]  

15 June 2009

Cheuk-Kwan Sun, Fan-Yen Lee, Jiunn-Jye Sheu, Chun-Man Yuen, Sarah Chua, Sheng-Ying Chung, Han-Tan Chai, Yen-Ta Chen, Ying-Hsien Kao, Li-Teh Chang, and Hon-Kan Yip

Early Combined Treatment with Cilostazol and Bone Marrow-Derived Endothelial Progenitor Cells Markedly Attenuates Pulmonary Arterial Hypertension in Rats
Published June 15, 2009; doi: 10.1124/jpet.109.154328 [Abstract] [PDF]  

11 June 2009

Teita Asano, Ken-Ichiro Tanaka, Naoki Yamakawa, Hiroaki Adachi, Gen Sobue, Hidemi Goto, Koji Takeuchi, and Tohru Mizushima

HSP70 CONFERS PROTECTION AGAINST INDOMETHACIN-INDUCED LESIONS OF THE SMALL INTESTINE
Published June 11, 2009; doi: 10.1124/jpet.109.152181 [Abstract] [PDF] [Data Supplement]  

10 June 2009

Florenta Aura Kullmann, Brian J Limberg, Debra E Artim, Mansi Shah, Thomas R Down, Dan Contract, John Wos, Jan S Rosenbaum, and William Chet de Groat

Effects of beta 3 adrenergic receptor activation on rat urinary bladder hyperactivity induced by ovariectomy
Published June 10, 2009; doi: 10.1124/jpet.109.155010 [Abstract] [PDF] [Data Supplement]  

Michael C. Montana, Laura F. Cavallone, Kristi K. Stubbert, Andrei D. Stefanescu, Evan D. Kharasch, and Robert W. Gereau

The mGlu5 antagonist fenobam is analgesic and has improved in vivo selectivity as compared to the prototypical antagonist MPEP
Published June 10, 2009; doi: 10.1124/jpet.109.154138 [Abstract] [PDF]  

Bruno Vie, Sylvie Sablayrolles, Robert Letienne, Bernard Vacher, Amaria Darmellah, Monique Bernard, Danielle Feuvray, and Bruno Le Grand

F 15845 prevents ischemia-induced heart remodeling by reduction of the intracellular Na⁺-overload
Published June 10, 2009; doi: 10.1124/jpet.109.153122 [Abstract] [PDF]  

9 June 2009

Santos M. Nicolau, Antonio M. G. de Diego, Lorena Cortes-Gil, Francisco Javier Egea Maiquez, Jose C. Gonzalez, Marta Mosquera, Manuela G Lopez, Jesus Miguel Hernandez-Guijo, and ANTONIO G. GARCIA

Mitochondrial Na⁺/Ca²⁺-exchanger blocker CGP37157 protects against chromaffin cell death elicited by veratridine
Published June 9, 2009; doi: 10.1124/jpet.109.154765 [Abstract] [PDF]  

Dulce Soler, Tobias Chapman, Li-Li Yang, Tim Wyant, Robert Egan, and Eric R. Fedyk

The Binding Specificity and Selective Antagonism of Vedolizumab, an Anti-₄₇ Integrin Therapeutic Antibody in Development for Inflammatory Bowel Diseases
Published June 9, 2009; doi: 10.1124/jpet.109.153973 [Abstract] [PDF]  

Sabzali Javadov, Morris Karmazyn, and Nelson Escobales

Mitochondrial permeability transition pore opening as a promising therapeutic target in cardiac diseases
Published June 9, 2009; doi: 10.1124/jpet.109.153213 [Abstract] [PDF]  

Leah Hanson, Annina Roeytenberg, Paula M. Martinez, Valerie G. Coppes, Donald C. Sweet, Reshma J. Rao, Dianne L. Marti, John D. Hoekman, Rachel B. Matthews, William H. Frey, and S. Scott Panter

Intranasal deferoxamine provides increased brain exposure and significant protection in rat ischemic stroke
Published June 9, 2009; doi: 10.1124/jpet.108.149807 [Abstract] [PDF]  

5 June 2009

Steven G. Kinsey, Jonathan Z. Long, Scott T. O'Neal, Rehab A. Abdullah, Justin L. Poklis, Dale L. Boger, Benjamin F. Cravatt, and Aron H. Lichtman

Blockade of endocannabinoid-degrading enzymes attenuates neuropathic pain
Published June 5, 2009; doi: 10.1124/jpet.109.155465 [Abstract] [PDF]  

Ritu Lal, Juthamas Sukbuntherng, Ezra H.L. Tai, Shubhra Upadhyay, Fenmei Yao, Mark S. Warren, Wendy Luo, Lin Bu, Son Nguyen, Jeanelle Zamora, Ge Peng, Tracy Dias, Ying Bao, Maria Ludwikow, Thu Phan, Randall A. Scheuerman, Hui Yan, Mark Gao, Quincey Q. Wu, Thamil Annamalai, Stephen P. Raillard, Kerry Koller, Mark A. Gallop, and Kenneth C. Cundy

Arbaclofen Placarbil, A Novel R-Baclofen Prodrug: Improved ADME Properties Compared to R-Baclofen
Published June 5, 2009; doi: 10.1124/jpet.108.149773 [Abstract] [PDF]  

4 June 2009

T Gregg Davis, John J Peterson, Jen-Pyng Kou, Elizabeth A Capper-Spudich, Doug Ball, Anthony T Nials, Joanne Wiseman, Yemisi E Solanke, Fiona S Lucas, Richard A Williamson, Livia Ferrari, Paul Wren, Richard G Knowles, Mary S Barnette, and Patricia L Podolin

The Identification of a Novel PDE4 Inhibitor, EPPA-1, with Improved Therapeutic Index using Pica Feeding in Rats as a Measure of Emetogenicity
Published June 4, 2009; doi: 10.1124/jpet.109.152454 [Abstract] [PDF]  

Stephen C. Alley, Xinqun Zhang, Nicole M. Okeley, Martha Anderson, Che-Leung Law, Peter D. Senter, and Dennis R. Benjamin

The Pharmacologic Basis for Antibody-Auristatin Conjugate Activity
Published June 4, 2009; doi: 10.1124/jpet.109.155549 [Abstract] [PDF]  

Kelly Conlon, Clare Christy, Simon Westbrook, Gavin Whitlock, Lee Roberts, Alan Stobie, and Gordon McMurray

Pharmacological properties of 2-((R-5-Chloro-4-methoxymethyl-indan-1-yl)-1H-imidazole (PF-3774076), a novel and selective 1_A adrenergic partial agonist in in vitro and in vivo models of urethral function
Published June 4, 2009; doi: 10.1124/jpet.109.154963 [Abstract] [PDF] [Data Supplement]  

3 June 2009

Anton Pekcec, Bernadette Unkruer, Juli Schlichtiger, Jonna Soerensen, Anika M.S. Hartz, Bjoern Bauer, Erwin A. van Vliet, Jan A. Gorter, and Heidrun Potschka

TARGETING PROSTAGLANDIN E₂ EP1 RECEPTORS PREVENTS SEIZURE-ASSOCIATED P-GLYCOPROTEIN UP-REGULATION
Published June 3, 2009; doi: 10.1124/jpet.109.152520 [Abstract] [PDF]  

Srividya Suryanarayana, Martin Gottle, Melanie Hubner, Andreas Gille, Tung-Chung Mou, Stephen R Sprang, Mark Richter, and Roland Seifert

Differential Inhibition of Various Adenylyl Cyclase Isoforms and Soluble Guanylyl Cyclase by 2',3'-O-(2,4,6-Trinitrophenyl)-Substituted Nucleoside 5'-Triphosphates
Published June 3, 2009; doi: 10.1124/jpet.109.155432 [Abstract] [PDF]  

2 June 2009

Zhu Li, Adam J Prus, Jin Dai, and Herbert Y Meltzer

Differential effects of M₁ and 5-HT_1A receptors on atypical antipsychotic drug-induced dopamine efflux in the medial prefrontal cortex
Published June 2, 2009; doi: 10.1124/jpet.109.155663 [Abstract] [PDF]  

Ying Chen, Sagar Agarwal, Naveed M. Shaik, Cliff Chen, Zheng Yang, and William F. Elmquist

P-glycoprotein and Breast Cancer Resistance Protein Influence Brain Distribution of Dasatinib
Published June 2, 2009; doi: 10.1124/jpet.109.154781 [Abstract] [PDF]  

Antonella Caputo, Alexandre Hinzpeter, Emanuela Caci, Nicoletta Pedemonte, Nicole Arous, Marco Di Duca, Olga Zegarra-Moran, Pascale Fanen, and Luis JV Galietta

MUTATION-SPECIFIC POTENCY AND EFFICACY OF CFTR CHLORIDE CHANNEL POTENTIATORS
Published June 2, 2009; doi: 10.1124/jpet.109.154146 [Abstract] [PDF]  

Jean-Pierre Evenou, Juergen Wagner, Gerhard Zenke, Volker Brinkmann, Kathrin Wagner, Jiri Kovarik, Karl Welzenbach, Gabriele Weitz-Schmidt, Christine Guntermann, Harry Towbin, Sylvain Cottens, Sandra Kaminski, Thomas Letschka, Christina Lutz-Nicoladoni, Thomas Gruber, Natascha Hermann-Kleiter, Nikolaus Thuille, and Gottfried Baier

The potent protein kinase C selective inhibitor AEB071 (Sotrastaurin)represents a new class of immunosuppressive agents affecting early T cell activation
Published June 2, 2009; doi: 10.1124/jpet.109.153205 [Abstract] [PDF] [Data Supplement]  

Jand Venes R Medeiros, Victor H Bezerra, Antoniella S Gomes, Andre Luiz R Barbosa, Roberto Cesar P Lima-Junior, Pedro Marcos G Soares, Gerly Anne C Brito, Ronaldo A Ribeiro, Fernando Queiroz Cunha, and Marcellus H L P Souza

HYDROGEN SULPHIDE PREVENTS ETHANOL-INDUCED GASTRIC DAMAGE IN MICE: ROLE OF K_ATP CHANNELS AND CAPSAICIN-SENSITIVE PRIMARY AFFERENT NEURONS
Published June 2, 2009; doi: 10.1124/jpet.109.152801 [Abstract] [PDF]  

Suneeta Tumati, Henry I. Yamamura, Todd W. Vanderah, William R. Roeske, and Eva V. Varga

Sustained morphine treatment augments capsaicin-evoked CGRP release from primary sensory neurons in a PKA and Raf-1- dependent manner
Published June 2, 2009; doi: 10.1124/jpet.109.151704 [Abstract] [PDF]  

29 May 2009

Gianluigi Tanda, Amy Newman, Aaron L. Ebbs, Valeria Tronci, Jennifer Green, Ronald J. Tallarida, and Jonathan L. Katz

Combinations of Cocaine with other Dopamine Uptake Inhibitors: Assessment of Additivity
Published May 29, 2009; doi: 10.1124/jpet.109.154302 [Abstract] [PDF]  

Hiromu Kawasaki, Shinji Eguchi, Satoko Miyashita, Shu Chan, Kazuhiro Hirai, Narumi Hobara, Ayako Yokomizo, Hidetoshi Fujiwara, Yoshito Zamami, Toshiro Koyama, Xin Jin, and Yoshihisa Kitamura

Proton acts as a neurotransmitter for nicotine-induced adrenergic and CGRPergic nerve-mediated vasodilation in the rat mesenteric artery
Published May 29, 2009; doi: 10.1124/jpet.108.149435 [Abstract] [PDF]  

28 May 2009

Yan Chen, Fang Luo, Cheng Yang, Chelsea Kirkmire, and Zaijie Jim Wang

Acute inhibition of Ca²⁺/calmodulin-dependent protein kinase II reverses experimental neuropathic pain in mice
Published May 28, 2009; doi: 10.1124/jpet.109.152165 [Abstract] [PDF]  

Yael Mardor, David Last, Dianne Daniels, Ran Shneor, Stephan E Maier, Dvora Nass, and Zvi Ram

Convection enhanced delivery of IL-4 pseudomonas exotoxin (PRX321): Increased distribution and MR monitoring
Published May 28, 2009; doi: 10.1124/jpet.109.154401 [Abstract] [PDF]  

Andrew J. King, Jason A. Segreti, Kelly J. Larson, Andrew J. Souers, Philip R. Kym, Regina M. Reilly, Gang Zhao, Scott W. Mittelstadt, and Bryan F. Cox

Diacylglycerol acyltransferase 1 (DGAT-1) inhibition lowers serum triglycerides in the Zucker fatty rat and the hyperlipidemic hamster
Published May 28, 2009; doi: 10.1124/jpet.109.154047 [Abstract] [PDF]  

Cynthia D. Sommers, Janice M. Thompson, Julia A. Guzova, Sheri L. Bonar, Randall K. Rader, Sumathy Mathialagan, Neetu Venkatraman, Vicky Holway, Larry E. Kahn, George Hu, Debra M. Meyer, Horng-chih Huang, Po-chang Chiang, John F. Schindler, Yiding Hu, Debra S. Garner, and Nandini N. Kishore

Novel Tight Binding Inhibitory Factor-B Kinase Inhibitors (IKK-2) Demonstrate Target Specific Anti-inflammatory Activities in Cellular Assays and Following Oral and Local Delivery in an In Vivo Model of Airway Inflammation
Published May 28, 2009; doi: 10.1124/jpet.108.147538 [Abstract] [PDF]  

Huixia Zhang, Xiaohui Wu, Suresh Babu Naraharisetti, Francisco Chung, Dale Whittington, Ahmad Mirfazaelian, and Jashvant D. Unadkat

Pregnancy does not increase CYP3A or P-glycoprotein activity in the non-human primate, Macaca. nemestrina
Published May 28, 2009; doi: 10.1124/jpet.109.153569 [Abstract] [PDF]  

Paola Casarosa, Thierry Bouyssou, Sabine Germeyer, Andreas Schnapp, Florian Gantner, and Michael P Pieper

Preclinical evaluation of Long Acting Muscarinic Antagonists (LAMAs): comparison of tiotropium and investigational drugs
Published May 28, 2009; doi: 10.1124/jpet.109.152470 [Abstract] [PDF]  

Yang Gao and Stephen Brimijoin

Lasting Reduction of Cocaine Action in Neostriatum-A Hydrolase Gene Therapy Approach
Published May 28, 2009; doi: 10.1124/jpet.109.152231 [Abstract] [PDF] [Data Supplement]  

Hazem F. Elewa, Anna Kozak, Azza B. El-Remessy, Reginald F. Frye, Maribeth H. Johnson, Adviye Ergul, and Susan C. Fagan

Early atorvastatin reduces hemorrhage after acute cerebral ischemia in diabetic rats
Published May 28, 2009; doi: 10.1124/jpet.108.146951 [Abstract] [PDF]  

26 May 2009

Qin Xue and Lubo Zhang

Prenatal hypoxia causes a sex-dependent increase in heart susceptibility to ischemia and reperfusion injury in adult male offspring: Role of PKC
Published May 26, 2009; doi: 10.1124/jpet.109.153239 [Abstract] [PDF]  

20 May 2009

Yong Chun Jin, Young Soo Lee, Young Min Kim, Hye Jung Kim, Han Geuk Seo, Jae Heun Lee, Hye Sook Yun-Choi, and Ki Churl Chang

CKD712, (S)-1-(-naphthylmethyl)-6,7-dihydroxy-1,2,3,4-tetrahydroisoquinoline, reduces rat myocardial apoptosis against ischemia and reperfusion injury by activation of PI3K/Akt signaling and anti-inflammatory action in vivo
Published May 20, 2009; doi: 10.1124/jpet.108.150342 [Abstract] [PDF]  

19 May 2009

Sherry A. Hudson, Nicolai Bovin, Ronald L. Schnaar, Paul R. Crocker, and Bruce S. Bochner

Eosinophil-selective binding and pro-apoptotic effect of a synthetic Siglec-8 ligand, polymeric 6'-sulfated sialyl Lewis X in vitro
Published May 19, 2009; doi: 10.1124/jpet.109.152439 [Abstract] [PDF]  

Kevin M Walton, Katherine Fisher, David Rubitski, Michael Marconi, Qing-Jun Meng, Martin Sladek, Jessica Adams, Michael Bass, Rama Chandrasekaran, Todd Butler, Matt Griffor, Francis Rajamohan, Megan Serpa, Yuhpyng Chen, Michelle Claffey, Michael Hastings, Andrew Loudon, Elizabeth Maywood, Jeffrey Ohren, Angela Doran, and Travis T Wager

Selective Inhibition of Casein Kinase 1 Epsilon Minimally Alters Circadian Clock Period
Published May 19, 2009; doi: 10.1124/jpet.109.151415 [Abstract] [PDF] [Data Supplement]  

15 May 2009

De-Ming Yang, Hsiao-Chuan Teng, Kuan-Hsuan Chen, Ming-Long Tsai, Ting-Kuei Lee, Yueh-Ching Chou, Chin-Wen Chi, Shi-Hwa Chiou, and Chen-Hsen Lee

Clodronate-induced cell apoptosis in human thyroid carcinoma is mediated via the P2 receptor signaling pathway
Published May 15, 2009; doi: 10.1124/jpet.109.152447 [Abstract] [PDF]  

Robert E Sorge and Paul B.S. Clarke

Rats self-administer intravenous nicotine delivered in a novel smoking-relevant procedure: effects of dopamine antagonists
Published May 15, 2009; doi: 10.1124/jpet.109.154641 [Abstract] [PDF]  

Resat Cinar and Maria Szucs

CB₁ receptor-independent actions of SR141716 on G-protein signaling; co-application with the µ-opioid agonist DAMGO unmasks novel, pertussis toxin-insensitive opioid signaling in MOR-CHO cells
Published May 15, 2009; doi: 10.1124/jpet.109.152710 [Abstract] [PDF]  

14 May 2009

Ji-Hyun Kim, Seong-Hae Park, Young Wha Moon, Sungmin Hwang, Donghoon Kim, Su-Hyun Jo, Seog Bae Oh, Joong Soo Kim, Jeong Won Jahng, Jong-Ho Lee, Sung Joong Lee, Se-Young Choi, and Kyungpyo Park

Histamine H1 Receptor Induces Cytosolic Calcium Increase And Aquaporin Translocation In Human Salivary Gland Cells
Published May 14, 2009; doi: 10.1124/jpet.109.153023 [Abstract] [PDF] [Data Supplement]  

12 May 2009

Sunil Sirohi, Shveta V. Dighe, Priyanka A. Madia, and Byron C. Yoburn

The Relative Potency of Inverse Opioid Agonists and A Neutral Opioid Antagonist in Precipitated Withdrawal and Antagonism of Analgesia and Toxicity
Published May 12, 2009; doi: 10.1124/jpet.109.152678 [Abstract] [PDF]  

Elizabeth M King, Manminder Kaur, Wei Gong, Christopher F Rider, Neil S Holden, and Robert Newton

Regulation of tristetraprolin expression by IL-1 and dexamethasone in human pulmonary epithelial cells: Roles for NF-B and p38 MAPK
Published May 12, 2009; doi: 10.1124/jpet.109.151423 [Abstract] [PDF] [Data Supplement]  

Kia J. Jackson, Carrie L. Walters, and M. Imad Damaj

2 subunit-containing Nicotinic Receptors Mediate Acute Nicotine-induced Activation of CaMKII-dependent Pathways in vivo
Published May 12, 2009; doi: 10.1124/jpet.109.153171 [Abstract] [PDF]  

8 May 2009

Takio Kitazawa, Koichi Asakawa, Tatsuro Nakamura, Hiroki Teraoka, Toshihiro Unno, Sei-ichi Komori, Masahisa Yamada, and Jurgen Wess

M₃ muscarinic receptors mediate positive inotropic responses in mouse atria: a study with muscarinic receptor knockout mice
Published May 8, 2009; doi: 10.1124/jpet.109.153304 [Abstract] [PDF]  

Jason C. Reneau, Mary E. Reyland, Jonathan Phillips, Carissa Kindy, and Roseanna Lisa Popp

Phorbol 12-myristate 13-acetate potentiation of N-Methyl-D-aspartate-induced currents in primary cultured cerebellar granule cells is mediated by Protein Kinase C
Published May 8, 2009; doi: 10.1124/jpet.109.153163 [Abstract] [PDF]  

7 May 2009

Fei Shen, Barbara J. Bailey, Shaoyou Chu, Aimee K. Bence, Xinjian Xue, Priscilla Erickson, Ahmad R. Safa, William T. Beck, and Leonard C. Erickson

Dynamic Assessment of Mitoxantrone Resistance and Modulation of Multidrug Resistance by PSC833 in Multidrug Resistant Human Cancer Cells
Published May 7, 2009; doi: 10.1124/jpet.109.153551 [Abstract] [PDF]  

Shih-Lu Wu, Jaw-Chyun Chen, Chia-Cheng Li, Hsin-Yi Lo, Tin-Yun Ho, and Chien-Yun Hsiang

Vanillin Improves and Prevents Trinitrobenzene Sulfonic Acid-Induced Colitis in Mice
Published May 7, 2009; doi: 10.1124/jpet.109.152835 [Abstract] [PDF]  

6 May 2009

Yan L. Dong, Yan Zhu, Yi Dong, Hui J. Yang, Yan Y. Zhao, Jie Y. Qi, Ying P. Wu, Hua Y. Zhu, and Ping Zheng

Neuroactive steroid dehydroepiandrosterone sulphate inhibits 5-HT-evoked glutamate release via activation of sigma-1 receptors and then inhibition of 5-HT₃ receptors in rat prelimbic cortex
Published May 6, 2009; doi: 10.1124/jpet.109.154294 [Abstract] [PDF]  

James A. Tumlin, Brian R. Roberts, Kenneth E. Kokko, Osama El Minshawy, and Jennifer L. Gooch

T cell receptor stimulated calcineurin activity is inhibited in isolated T cells from transplant patients
Published May 6, 2009; doi: 10.1124/jpet.109.154096 [Abstract] [PDF]  

Nisha Kurian, Caroline J Hall, Graeme F Wilkinson, Michael Sullivan, Andrew B Tobin, and Gary B Willars

Full and partial agonists of muscarinic M₃ receptors reveal single and oscillatory Ca²⁺ responses by ₂-adrenoceptors
Published May 6, 2009; doi: 10.1124/jpet.109.153619 [Abstract] [PDF]  

5 May 2009

Maria F.M. Braga, Vassiliki Aroniadou-Anderjaska, He Li, and Michael A. Rogawski

Topiramate Reduces Excitability in the Basolateral Amygdala by Selectively Inhibiting GluK1 (GluR5) Kainate Receptors on Interneurons and Positively Modulating GABA_A Receptors on Principal Neurons
Published May 5, 2009; doi: 10.1124/jpet.109.153908 [Abstract] [PDF]  

4 May 2009

Jianghong Fan, Shanjun Liu, Yimin Du, Jodi Morrison, Robert Shipman, and K. Sandy Pang

Upregulation of Transporters and Enzymes by the Vitamin D Receptor (VDR) and Ligands [1,25-Dihydroxyvitamin D₃ and Vitamin D Analogues in the Caco-2 Cell Monolayer
Published May 4, 2009; doi: 10.1124/jpet.108.149815 [Abstract] [PDF]  

1 May 2009

Anthie Ellis, Kenichi Goto, Daniel J. Chaston, Therese D. Brackenbury, Kate R. Meaney, John R. Falck, Richard J.H. Wojcikiewicz, and Caryl E. Hill

Enalapril treatment alters the contribution of EETs but not gap junctions to EDHF activity in mesenteric arteries of spontaneously hypertensive rats
Published May 1, 2009; doi: 10.1124/jpet.109.152116 [Abstract] [PDF]  

30 April 2009

Moshe Y Levy, Abhinav Sidana, Wasim H Chowdhury, Steven B Solomon, Charles G Drake, Ronald Rodriguez, and Ephraim J Fuchs

Cyclophosphamide unmasks an anti-metastatic effect of local tumor cryoablation
Published April 30, 2009; doi: 10.1124/jpet.109.152603 [Abstract] [PDF]  

29 April 2009

Yuzhi Wu, Yejia Song, Luiz Belardinelli, and John C. Shryock

The late I_Na Inhibitor Ranolazine Attenuates Effects of Palmitoyl-L-Carnitine to Increase Late I_Na and Cause Ventricular Diastolic Dysfunction
Published April 29, 2009; doi: 10.1124/jpet.109.151936 [Abstract] [PDF]  

Mark A Smith, Jennifer L Greene-Naples, Jennifer N Felder, Jordan C Iordanou, Megan A Lyle, and Katherine L Walker

The effects of repeated opioid administration on locomotor activity: II. Unidirectional Cross-sensitization to cocaine
Published April 29, 2009; doi: 10.1124/jpet.108.150037 [Abstract] [PDF]  

Mark A Smith, Jennifer L Greene-Naples, Megan A Lyle, Jordan C Iordanou, and Jennifer N Felder

The Effects of Repeated Opioid Administration on Locomotor Activity: I. Role of an Opioid's Relative Selectivity at Mu and Kappa Receptors
Published April 29, 2009; doi: 10.1124/jpet.108.150011 [Abstract] [PDF]  

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