Table of Contents

Drug Discovery and Translational Medicine

• You have access

  A Novel In Vivo Receptor Occupancy Methodology for the Glucocorticoid Receptor: Toward An Improved Understanding of Lung Pharmacokinetic/Pharmacodynamic Relationships

  Elin Boger, Pär Ewing, Ulf G. Eriksson, Britt-Marie Fihn, Michael Chappell, Neil Evans and Markus Fridén

  Journal of Pharmacology and Experimental Therapeutics May 2015, 353 (2) 279-287; DOI: https://doi.org/10.1124/jpet.114.221226
• You have access

  PF-1355, a Mechanism-Based Myeloperoxidase Inhibitor, Prevents Immune Complex Vasculitis and Anti–Glomerular Basement Membrane Glomerulonephritis

  Wei Zheng, Roscoe Warner, Roger Ruggeri, Chunyan Su, Christian Cortes, Athanasia Skoura, Jessica Ward, Kay Ahn, Amit Kalgutkar, Dexue Sun, Tristan S. Maurer, Paul D. Bonin, Carlin Okerberg, Walter Bobrowski, Thomas Kawabe, Yanwei Zhang, Timothy Coskran, Sammy Bell, Bhupesh Kapoor, Kent Johnson and Leonard Buckbinder

  Journal of Pharmacology and Experimental Therapeutics May 2015, 353 (2) 288-298; DOI: https://doi.org/10.1124/jpet.114.221788
• You have access

  Beneficial Effect of the Soluble Guanylyl Cyclase Stimulator BAY 41-2272 on Impaired Penile Erection in db/db^−/− Type II Diabetic and Obese Mice

  Kenia Pedrosa Nunes, Cleber E. Teixeira, Fernanda B. M. Priviero, Haroldo A. Toque and R. Clinton Webb

  Journal of Pharmacology and Experimental Therapeutics May 2015, 353 (2) 330-339; DOI: https://doi.org/10.1124/jpet.114.220970
• You have access

  Pharmacological Characterization of AZD5069, a Slowly Reversible CXC Chemokine Receptor 2 Antagonist

  David J. Nicholls, Katherine Wiley, Ian Dainty, Fraser MacIntosh, Caroline Phillips, Alasdair Gaw and Carina Kärrman Mårdh

  Journal of Pharmacology and Experimental Therapeutics May 2015, 353 (2) 340-350; DOI: https://doi.org/10.1124/jpet.114.221358
• You have access

  A Small Molecule with Anticancer and Antimetastatic Activities Induces Rapid Mitochondrial-Associated Necrosis in Breast Cancer

  Anja Bastian, Jessica E. Thorpe, Bryan C. Disch, Lora C. Bailey-Downs, Aleem Gangjee, Ravi K. V. Devambatla, Jim Henthorn, Kenneth M. Humphries, Shraddha S. Vadvalkar and Michael A. Ihnat

  Journal of Pharmacology and Experimental Therapeutics May 2015, 353 (2) 392-404; DOI: https://doi.org/10.1124/jpet.114.220335
• You have access

  VX-509 (Decernotinib) Is a Potent and Selective Janus Kinase 3 Inhibitor That Attenuates Inflammation in Animal Models of Autoimmune Disease

  Sudipta Mahajan, James K. Hogan, Dina Shlyakhter, Luke Oh, Francesco G. Salituro, Luc Farmer and Thomas C. Hoock

  Journal of Pharmacology and Experimental Therapeutics May 2015, 353 (2) 405-414; DOI: https://doi.org/10.1124/jpet.114.221176
• You have access

  The Ellagic Acid Derivative 4,4′-Di-O-Methylellagic Acid Efficiently Inhibits Colon Cancer Cell Growth through a Mechanism Involving WNT16

  Ana Ramírez de Molina, Teodoro Vargas, Susana Molina, Jenifer Sánchez, Jorge Martínez-Romero, Margarita González-Vallinas, Roberto Martín-Hernández, Ruth Sánchez-Martínez, Marta Gómez de Cedrón, Alberto Dávalos, Luca Calani, Daniele Del Rio, Antonio González-Sarrías, Juan Carlos Espín, Francisco A. Tomás-Barberán and Guillermo Reglero

  Journal of Pharmacology and Experimental Therapeutics May 2015, 353 (2) 433-444; DOI: https://doi.org/10.1124/jpet.114.221796