Journal of Pharmacology and Experimental Therapeutics: 352 (2)

February 01, 2015; Volume 352,Issue 2

Highlighted Papers

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Role of μ-Agonist Efficacy and Noxious Stimulus Intensity
Journal of Pharmacology and Experimental Therapeutics February 2015, 352 (2) 194; DOI: https://doi.org/10.1124/jpet.114.0215HI
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A Novel ApoC-II Mimetic Peptide That Activates LPL and Decreases Triglycerides
Journal of Pharmacology and Experimental Therapeutics February 2015, 352 (2) 194; DOI: https://doi.org/10.1124/jpet.114.0215HIa
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A Novel MitoNEET Ligand Improves Diabetes in db/db Mice
Journal of Pharmacology and Experimental Therapeutics February 2015, 352 (2) 194; DOI: https://doi.org/10.1124/jpet.114.0215HIb
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Chimeric TK-NOG Mice: A Predictive Model for Cholestatic Human Liver Disease
Journal of Pharmacology and Experimental Therapeutics February 2015, 352 (2) 194; DOI: https://doi.org/10.1124/jpet.114.0215HIc

Behavioral Pharmacology

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Δ⁹-Tetrahydrocannabinol and Endocannabinoid Degradative Enzyme Inhibitors Attenuate Intracranial Self-Stimulation in Mice
Jason M. Wiebelhaus, Travis W. Grim, Robert A. Owens, Matthew F. Lazenka, Laura J. Sim-Selley, Rehab A. Abdullah, Micah J. Niphakis, Robert E. Vann, Benjamin F. Cravatt, Jenny L. Wiley, S. Stevens Negus and Aron H. Lichtman

Journal of Pharmacology and Experimental Therapeutics February 2015, 352 (2) 195-207; DOI: https://doi.org/10.1124/jpet.114.218677
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Effects of μ-Opioid Receptor Agonists in Assays of Acute Pain-Stimulated and Pain-Depressed Behavior in Male Rats: Role of μ-Agonist Efficacy and Noxious Stimulus Intensity
Ahmad A. Altarifi, Kenner C. Rice and S. Stevens Negus

Journal of Pharmacology and Experimental Therapeutics February 2015, 352 (2) 208-217; DOI: https://doi.org/10.1124/jpet.114.219873

Cardiovascular

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Kinin Receptor Agonism Restores Hindlimb Postischemic Neovascularization Capacity in Diabetic Mice
Dorinne Desposito, Louis Potier, Catherine Chollet, Fernand Gobeil, Ronan Roussel, Francois Alhenc-Gelas, Nadine Bouby and Ludovic Waeckel

Journal of Pharmacology and Experimental Therapeutics February 2015, 352 (2) 218-226; DOI: https://doi.org/10.1124/jpet.114.219196
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A Novel Apolipoprotein C-II Mimetic Peptide That Activates Lipoprotein Lipase and Decreases Serum Triglycerides in Apolipoprotein E–Knockout Mice
Marcelo J. A. Amar, Toshihiro Sakurai, Akiko Sakurai-Ikuta, Denis Sviridov, Lita Freeman, Lusana Ahsan and Alan T. Remaley

Journal of Pharmacology and Experimental Therapeutics February 2015, 352 (2) 227-235; DOI: https://doi.org/10.1124/jpet.114.220418
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Estrogen Receptor Subtypes Mediate Distinct Microvascular Dilation and Reduction in [Ca²⁺]_i in Mesenteric Microvessels of Female Rat
Marc Q. Mazzuca, Karina M. Mata, Wei Li, Sridhar S. Rangan and Raouf A. Khalil

Journal of Pharmacology and Experimental Therapeutics February 2015, 352 (2) 291-304; DOI: https://doi.org/10.1124/jpet.114.219865

Cellular and Molecular

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MS-275 Inhibits Aroclor 1254–Induced SH-SY5Y Neuronal Cell Toxicity by Preventing the Formation of the HDAC3/REST Complex on the Synapsin-1 Promoter
Luigi Formisano, Natascia Guida, Giusy Laudati, Luigi Mascolo, Gianfranco Di Renzo and Lorella M. T. Canzoniero

Journal of Pharmacology and Experimental Therapeutics February 2015, 352 (2) 236-243; DOI: https://doi.org/10.1124/jpet.114.219345
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Omega-3 Fatty Acids and Other FFA4 Agonists Inhibit Growth Factor Signaling in Human Prostate Cancer Cells
Ze Liu, Mandi M. Hopkins, Zhihong Zhang, Chrystal B. Quisenberry, Louise C. Fix, Brianna M. Galvan and Kathryn E. Meier

Journal of Pharmacology and Experimental Therapeutics February 2015, 352 (2) 380-394; DOI: https://doi.org/10.1124/jpet.114.218974

Drug Discovery and Translational Medicine

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Polythiol-Containing, Recombinant Mannosylated-Albumin Is a Superior CD68⁺/CD206⁺ Kupffer Cell–Targeted Nanoantioxidant for Treatment of Two Acute Hepatitis Models
Hitoshi Maeda, Kenshiro Hirata, Hiroshi Watanabe, Yu Ishima, Victor Tuan Giam Chuang, Kazuaki Taguchi, Akihito Inatsu, Manabu Kinoshita, Motohiko Tanaka, Yutaka Sasaki, Masaki Otagiri and Toru Maruyama

Journal of Pharmacology and Experimental Therapeutics February 2015, 352 (2) 244-257; DOI: https://doi.org/10.1124/jpet.114.219493
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Pharmacological Characterization of a Novel Liver X Receptor Agonist with Partial LXRα Activity and a Favorable Window in Nonhuman Primates
Todd G. Kirchgessner, Richard Martin, Paul Sleph, Denise Grimm, Xiaoqin Liu, John Lupisella, James Smalley, Rangaraj Narayanan, Yinong Xie, Jacek Ostrowski, Glenn H. Cantor, Raju Mohan and Ellen Kick

Journal of Pharmacology and Experimental Therapeutics February 2015, 352 (2) 305-314; DOI: https://doi.org/10.1124/jpet.114.219923
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AMG 580: A Novel Small Molecule Phosphodiesterase 10A (PDE10A) Positron Emission Tomography Tracer
Hang Chen, Dianna Lester-Zeiner, Jianxia Shi, Silke Miller, Charlie Glaus, Essa Hu, Ning Chen, Jessica Able, Christopher Biorn, Jamie Wong, Ji Ma, Klaus Michelsen, Geraldine Hill Della Puppa, Tim Kazules, Hui Hannah Dou, Santosh Talreja, Xiaoning Zhao, Ada Chen, Shannon Rumfelt, Roxanne K. Kunz, Hu Ye, Oliver R. Thiel, Toni Williamson, Carl Davis, Amy Porter, David Immke, Jennifer R. Allen and James Treanor

Journal of Pharmacology and Experimental Therapeutics February 2015, 352 (2) 327-337; DOI: https://doi.org/10.1124/jpet.114.220517
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A Novel MitoNEET Ligand, TT01001, Improves Diabetes and Ameliorates Mitochondrial Function in db/db Mice
Takehiro Takahashi, Masashi Yamamoto, Kazutoshi Amikura, Kozue Kato, Takashi Serizawa, Kanako Serizawa, Daisuke Akazawa, Takumi Aoki, Koji Kawai, Emi Ogasawara, Jun-Ichi Hayashi, Kazuto Nakada and Mie Kainoh

Journal of Pharmacology and Experimental Therapeutics February 2015, 352 (2) 338-345; DOI: https://doi.org/10.1124/jpet.114.220673

Gastrointestinal, Hepatic, Pulmonary, and Renal

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Notoginsenoside R1 Attenuates Experimental Inflammatory Bowel Disease via Pregnane X Receptor Activation
Jingjing Zhang, Lili Ding, Baocan Wang, Gaiyan Ren, Aning Sun, Chao Deng, Xiaohui Wei, Sridhar Mani, Zhengtao Wang and Wei Dou

Journal of Pharmacology and Experimental Therapeutics February 2015, 352 (2) 315-324; DOI: https://doi.org/10.1124/jpet.114.218750
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Suppression of Mitochondrial Biogenesis through Toll-Like Receptor 4–Dependent Mitogen-Activated Protein Kinase Kinase/Extracellular Signal-Regulated Kinase Signaling in Endotoxin-Induced Acute Kidney Injury
Joshua A. Smith, L. Jay Stallons, Justin B. Collier, Kenneth D. Chavin and Rick G. Schnellmann

Journal of Pharmacology and Experimental Therapeutics February 2015, 352 (2) 346-357; DOI: https://doi.org/10.1124/jpet.114.221085

Metabolism, Transport, and Pharmacogenomics

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A UGT2B10 Splicing Polymorphism Common in African Populations May Greatly Increase Drug Exposure
Stephen Fowler, Heidemarie Kletzl, Moshe Finel, Nenad Manevski, Paul Schmid, Dietrich Tuerck, Roger D. Norcross, Marius C. Hoener, Olivia Spleiss and Victor A. Iglesias

Journal of Pharmacology and Experimental Therapeutics February 2015, 352 (2) 358-367; DOI: https://doi.org/10.1124/jpet.114.220194
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Glutamate-Mediated Upregulation of the Multidrug Resistance Protein 2 in Porcine and Human Brain Capillaries
Hiram Luna-Munguia, Josephine D. Salvamoser, Bettina Pascher, Tom Pieper, Thekla Getzinger, Manfred Kudernatsch, Gerhard Kluger and Heidrun Potschka

Journal of Pharmacology and Experimental Therapeutics February 2015, 352 (2) 368-378; DOI: https://doi.org/10.1124/jpet.114.218180

Neuropharmacology

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Aberrant Histone Acetylation Promotes Mitochondrial Respiratory Suppression in the Brain of Alcoholic Rats
Marianna E. Jung and Daniel B. Metzger

Journal of Pharmacology and Experimental Therapeutics February 2015, 352 (2) 258-266; DOI: https://doi.org/10.1124/jpet.114.219311
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Sensitivity of N-Methyl-d-Aspartate Receptor–Mediated Excitatory Postsynaptic Potentials and Synaptic Plasticity to TCN 201 and TCN 213 in Rat Hippocampal Slices
Yukitoshi Izumi and Charles F. Zorumski

Journal of Pharmacology and Experimental Therapeutics February 2015, 352 (2) 267-273; DOI: https://doi.org/10.1124/jpet.114.220582
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Age-Dependent Contribution of P/Q- and R-Type Ca²⁺ Channels to Neuromuscular Transmission in Lethargic Mice
Elizabeth Molina-Campos, Youfen Xu and William D. Atchison

Journal of Pharmacology and Experimental Therapeutics February 2015, 352 (2) 395-404; DOI: https://doi.org/10.1124/jpet.114.216143
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R-(+) and S-(−) Isomers of Cotinine Augment Cholinergic Responses In Vitro and In Vivo
Alvin V. Terry, Patrick M. Callahan and Daniel Bertrand

Journal of Pharmacology and Experimental Therapeutics February 2015, 352 (2) 405-418; DOI: https://doi.org/10.1124/jpet.114.219881

Toxicology

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Chimeric TK-NOG Mice: A Predictive Model for Cholestatic Human Liver Toxicity
Dan Xu, Manhong Wu, Sachiko Nishimura, Toshihiko Nishimura, Sara A. Michie, Ming Zheng, Zicheng Yang, Alexander John Yates, Jeffrey S. Day, Kathleen M. Hillgren, Saori Takedai Takeda, Yuan Guan, Yingying Guo and Gary Peltz

Journal of Pharmacology and Experimental Therapeutics February 2015, 352 (2) 274-280; DOI: https://doi.org/10.1124/jpet.114.220798
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Multiple Compound-Related Adverse Properties Contribute to Liver Injury Caused by Endothelin Receptor Antagonists
J. Gerry Kenna, Simone H. Stahl, Julie A. Eakins, Alison J. Foster, Linda C. Andersson, Jonas Bergare, Martin Billger, Marie Elebring, Charles S. Elmore and Richard A. Thompson

Journal of Pharmacology and Experimental Therapeutics February 2015, 352 (2) 281-290; DOI: https://doi.org/10.1124/jpet.114.220491

Notice of Retraction

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Re: Kadam RS and Kompella UB (2010) Influence of Lipophilicity on Drug Partitioning into Sclera, Choroid-Retinal Pigment Epithelium, Retina, Trabecular Meshwork, and Optic Nerve. J Pharmacol Exp Ther 332:1107–1120; doi:10.1124/jpet.109.161570
Journal of Pharmacology and Experimental Therapeutics February 2015, 352 (2) 326; DOI: https://doi.org/10.1124/jpet.114.02er15

Errata

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Correction to “Evidence for α-Helices in the Large Intracellular Domain Mediating Modulation of the α1-Glycine Receptor by Ethanol and Gβγ”
Journal of Pharmacology and Experimental Therapeutics February 2015, 352 (2) 325; DOI: https://doi.org/10.1124/jpet.114.217976err
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Correction to “The Angiotensin IV Analog Nle-Tyr-Leu-ψ-(CH₂-NH₂)^3-4-His-Pro-Phe (Norleual) Can Act as a Hepatocyte Growth Factor/c-Met Inhibitor”
Journal of Pharmacology and Experimental Therapeutics February 2015, 352 (2) 379; DOI: https://doi.org/10.1124/jpet.114.161711err

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Table of Contents

Highlighted Papers

Behavioral Pharmacology

Cardiovascular

Cellular and Molecular

Drug Discovery and Translational Medicine

Gastrointestinal, Hepatic, Pulmonary, and Renal

Metabolism, Transport, and Pharmacogenomics

Neuropharmacology

Toxicology

Notice of Retraction

Errata

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