Journal of Pharmacology and Experimental Therapeutics: 360 (1)

January 01, 2017; Volume 360,Issue 1

Minireviews

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Estrogen Signaling as a Therapeutic Target in Neurodevelopmental Disorders
Amanda Crider and Anilkumar Pillai

Journal of Pharmacology and Experimental Therapeutics January 2017, 360 (1) 48-58; DOI: https://doi.org/10.1124/jpet.116.237412
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Oxidative Stress and the Central Nervous System
Samina Salim

Journal of Pharmacology and Experimental Therapeutics January 2017, 360 (1) 201-205; DOI: https://doi.org/10.1124/jpet.116.237503

Cardiovascular

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Xanthohumol Modulates Calcium Signaling in Rat Ventricular Myocytes: Possible Antiarrhythmic Properties
Juan Jose Arnaiz-Cot, Lars Cleemann and Martin Morad

Journal of Pharmacology and Experimental Therapeutics January 2017, 360 (1) 239-248; DOI: https://doi.org/10.1124/jpet.116.236588

Cellular and Molecular

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Mutation-Induced Functional Alterations of CCR6
Bina Julian, Kevin Gao, Benjamin N. Harwood, Martin Beinborn and Alan S. Kopin

Journal of Pharmacology and Experimental Therapeutics January 2017, 360 (1) 106-116; DOI: https://doi.org/10.1124/jpet.116.237669

Chemotherapy, Antibiotics, and Gene Therapy

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Alternative RNA Processing of Topoisomerase IIα in Etoposide-Resistant Human Leukemia K562 Cells: Intron Retention Results in a Novel C-Terminal Truncated 90-kDa Isoform
Ragu Kanagasabai, Lucas Serdar, Soumendrakrishna Karmahapatra, Corey A. Kientz, Justin Ellis, Mary K. Ritke, Terry S. Elton and Jack C. Yalowich

Journal of Pharmacology and Experimental Therapeutics January 2017, 360 (1) 152-163; DOI: https://doi.org/10.1124/jpet.116.237107
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Quantitative Analyses of Synergistic Responses between Cannabidiol and DNA-Damaging Agents on the Proliferation and Viability of Glioblastoma and Neural Progenitor Cells in Culture
Liting Deng, Lindsay Ng, Tatsuya Ozawa and Nephi Stella

Journal of Pharmacology and Experimental Therapeutics January 2017, 360 (1) 215-224; DOI: https://doi.org/10.1124/jpet.116.236968

Drug Discovery and Translational Medicine

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Selective Inhibition of Autotaxin Is Efficacious in Mouse Models of Liver Fibrosis
Gretchen Bain, Kristen E. Shannon, Fei Huang, Janice Darlington, Lance Goulet, Patricia Prodanovich, Gina L. Ma, Angelina M. Santini, Adam J. Stein, Dave Lonergan, Christopher D. King, Imelda Calderon, Andiliy Lai, John H. Hutchinson and Jilly F. Evans

Journal of Pharmacology and Experimental Therapeutics January 2017, 360 (1) 1-13; DOI: https://doi.org/10.1124/jpet.116.237156
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An HDAC6 Inhibitor Confers Protection and Selectively Inhibits B-Cell Infiltration in DSS-Induced Colitis in Mice
Anh Do, Robert C. Reid, Rink-Jan Lohman, Matthew J. Sweet, David P. Fairlie and Abishek Iyer

Journal of Pharmacology and Experimental Therapeutics January 2017, 360 (1) 140-151; DOI: https://doi.org/10.1124/jpet.116.236711

Gastrointestinal, Hepatic, Pulmonary, and Renal

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Silencer-of-Death Domain Mediates Acid-Induced Decrease in Cell Apoptosis in Barrett’s Associated Esophageal Adenocarcinoma Cells
Dan Li, Jie Hong and Weibiao Cao

Journal of Pharmacology and Experimental Therapeutics January 2017, 360 (1) 14-22; DOI: https://doi.org/10.1124/jpet.116.236620
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Urinary Excretion Contributes to Long-Lasting Blockade of Bladder Muscarinic Receptors by Imidafenacin: Effect of Bilateral Ureteral Ligation
Yoshihiko Ito, Shiori Kuraoka, Soma Endo, Ayaka Takahashi, Satomi Onoue and Shizuo Yamada

Journal of Pharmacology and Experimental Therapeutics January 2017, 360 (1) 69-74; DOI: https://doi.org/10.1124/jpet.116.236497
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Disrupted Murine Gut–to–Human Liver Signaling Alters Bile Acid Homeostasis in Humanized Mouse Liver Models
Edwin C. Y. Chow, Holly P. Quach, Yueping Zhang, Jason Z. Y. Wang, David C. Evans, Albert P. Li, Jose Silva, Rommel G. Tirona, Yurong Lai and K. Sandy Pang

Journal of Pharmacology and Experimental Therapeutics January 2017, 360 (1) 174-191; DOI: https://doi.org/10.1124/jpet.116.236935

Inflammation, Immunopharmacology, and Asthma

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NOX1/NADPH Oxidase Expressed in Colonic Macrophages Contributes to the Pathogenesis of Colonic Inflammation in Trinitrobenzene Sulfonic Acid–Induced Murine Colitis
Haruka Yokota, Ayaka Tsuzuki, Yuki Shimada, Azusa Imai, Daichi Utsumi, Takuya Tsukahara, Misaki Matsumoto, Kikuko Amagase, Kazumi Iwata, Akio Nakamura, Chihiro Yabe-Nishimura and Shinichi Kato

Journal of Pharmacology and Experimental Therapeutics January 2017, 360 (1) 192-200; DOI: https://doi.org/10.1124/jpet.116.235580

Metabolism, Transport, and Pharmacogenomics

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Role of Equilibrative Nucleobase Transporter 1/SLC43A3 as a Ganciclovir Transporter in the Induction of Cytotoxic Effect of Ganciclovir in a Suicide Gene Therapy with Herpes Simplex Virus Thymidine Kinase
Junji Furukawa, Katsuhisa Inoue, Kinya Ohta, Tomoya Yasujima, Yoshihisa Mimura and Hiroaki Yuasa

Journal of Pharmacology and Experimental Therapeutics January 2017, 360 (1) 59-68; DOI: https://doi.org/10.1124/jpet.116.236984
Open Access
Quantitative Assessment of Population Variability in Hepatic Drug Metabolism Using a Perfused Three-Dimensional Human Liver Microphysiological System
N. Tsamandouras, T. Kostrzewski, C. L. Stokes, L. G. Griffith, D. J. Hughes and M. Cirit

Journal of Pharmacology and Experimental Therapeutics January 2017, 360 (1) 95-105; DOI: https://doi.org/10.1124/jpet.116.237495
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Predictors of Variation in CYP2A6 mRNA, Protein, and Enzyme Activity in a Human Liver Bank: Influence of Genetic and Nongenetic Factors
Julie-Anne Tanner, Bhagwat Prasad, Katrina G. Claw, Patricia Stapleton, Amarjit Chaudhry, Erin G. Schuetz, Kenneth E. Thummel and Rachel F. Tyndale

Journal of Pharmacology and Experimental Therapeutics January 2017, 360 (1) 129-139; DOI: https://doi.org/10.1124/jpet.116.237594
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Low Potential of Basimglurant to Be Involved in Drug-Drug Interactions: Influence of Non–Michaelis-Menten P450 Kinetics on Fraction Metabolized
Stephen Fowler, Elena Guerini, NaHong Qiu, Yumi Cleary, Neil Parrott, Gerard Greig and Navita L. Mallalieu

Journal of Pharmacology and Experimental Therapeutics January 2017, 360 (1) 164-173; DOI: https://doi.org/10.1124/jpet.116.237214
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Hormonal and Chemical Regulation of the Glut9 Transporter in Mice
Pengli Bu, Yuan Le, Yue Zhang and Xingguo Cheng

Journal of Pharmacology and Experimental Therapeutics January 2017, 360 (1) 206-214; DOI: https://doi.org/10.1124/jpet.116.237040

Neuropharmacology

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The M₁ Muscarinic Receptor Antagonist VU0255035 Delays the Development of Status Epilepticus after Organophosphate Exposure and Prevents Hyperexcitability in the Basolateral Amygdala
Steven L. Miller, Vassiliki Aroniadou-Anderjaska, Volodymyr I. Pidoplichko, Taiza H. Figueiredo, James P. Apland, Jishnu K. S. Krishnan and Maria F. M. Braga

Journal of Pharmacology and Experimental Therapeutics January 2017, 360 (1) 23-32; DOI: https://doi.org/10.1124/jpet.116.236125
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Structure-Activity Relationships of Substituted Cathinones, with Transporter Binding, Uptake, and Release
Amy J. Eshleman, Katherine M. Wolfrum, John F. Reed, Sunyoung O. Kim, Tracy Swanson, Robert A. Johnson and Aaron Janowsky

Journal of Pharmacology and Experimental Therapeutics January 2017, 360 (1) 33-47; DOI: https://doi.org/10.1124/jpet.116.236349
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TAK-063, a Novel Phosphodiesterase 10A Inhibitor, Protects from Striatal Neurodegeneration and Ameliorates Behavioral Deficits in the R6/2 Mouse Model of Huntington’s Disease
Akina Harada, Kazunori Suzuki and Haruhide Kimura

Journal of Pharmacology and Experimental Therapeutics January 2017, 360 (1) 75-83; DOI: https://doi.org/10.1124/jpet.116.237388
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Ontogeny of Norepinephrine Transporter Expression and Antidepressant-Like Response to Desipramine in Wild-Type and Serotonin Transporter Mutant Mice
Nathan C. Mitchell, Melodi A. Bowman, Georgianna G. Gould, Wouter Koek and Lynette C. Daws

Journal of Pharmacology and Experimental Therapeutics January 2017, 360 (1) 84-94; DOI: https://doi.org/10.1124/jpet.116.237305
Open Access
An Allosteric Potentiator of the Dopamine D1 Receptor Increases Locomotor Activity in Human D1 Knock-In Mice without Causing Stereotypy or Tachyphylaxis
Kjell A. Svensson, Beverly A. Heinz, John M. Schaus, James P. Beck, Junliang Hao, Joseph H. Krushinski, Matthew R. Reinhard, Michael P. Cohen, Sarah L. Hellman, Brian G. Getman, Xushan Wang, Michelle M. Menezes, Deanna L. Maren, Julie F. Falcone, Wesley H. Anderson, Rebecca A. Wright, S. Michelle Morin, Kelly L. Knopp, Benjamin L. Adams, Borys Rogovoy, Ilya Okun, Todd M. Suter, Michael A. Statnick, Donald R. Gehlert, David L. Nelson, Virginia L. Lucaites, Renee Emkey, Neil W. DeLapp, Todd R. Wiernicki, Jeffrey W. Cramer, Charles R. Yang and Robert F. Bruns

Journal of Pharmacology and Experimental Therapeutics January 2017, 360 (1) 117-128; DOI: https://doi.org/10.1124/jpet.116.236372

Toxicology

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Bruton’s Tyrosine Kinase Small Molecule Inhibitors Induce a Distinct Pancreatic Toxicity in Rats
Rebecca I. Erickson, Leah K. Schutt, Jacqueline M. Tarrant, Michelle McDowell, Lichuan Liu, Adam R. Johnson, Sock-Cheng Lewin-Koh, Maj Hedehus, Jed Ross, Richard A. D. Carano, Karin Staflin, Fiona Zhong, James J. Crawford, Shelly Zhong, Karin Reif, Arna Katewa, Harvey Wong, Wendy B. Young, Donna M. Dambach and Dinah L. Misner

Journal of Pharmacology and Experimental Therapeutics January 2017, 360 (1) 226-238; DOI: https://doi.org/10.1124/jpet.116.236224

Erratum

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Correction to: “A Small Molecule with Anticancer and Antimetastatic Activities Induces Rapid Mitochondrial-Associated Necrosis in Breast Cancer
Journal of Pharmacology and Experimental Therapeutics January 2017, 360 (1) 225; DOI: https://doi.org/10.1124/jpet.113.220335err

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Table of Contents

Minireviews

Cardiovascular

Cellular and Molecular

Chemotherapy, Antibiotics, and Gene Therapy

Drug Discovery and Translational Medicine

Gastrointestinal, Hepatic, Pulmonary, and Renal

Inflammation, Immunopharmacology, and Asthma

Metabolism, Transport, and Pharmacogenomics

Neuropharmacology

Toxicology

Erratum

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