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Neutral Endopeptidase-Resistant C-Type Natriuretic Peptide Variant Represents a New Therapeutic Approach for Treatment of Fibroblast Growth Factor Receptor 3–Related Dwarfism
Daniel J. Wendt, Melita Dvorak-Ewell, Sherry Bullens, Florence Lorget, Sean M. Bell, Jeff Peng, Sianna Castillo, Mika Aoyagi-Scharber, Charles A. O’Neill, Pavel Krejci, William R. Wilcox, David L. Rimoin and Stuart Bunting

Journal of Pharmacology and Experimental Therapeutics April 2015, 353 (1) 132-149; DOI: https://doi.org/10.1124/jpet.114.218560
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2-Acetylcyclopentanone, an Enolate-Forming 1,3-Dicarbonyl Compound, Is Cytoprotective in Warm Ischemia-Reperfusion Injury of Rat Liver
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Journal of Pharmacology and Experimental Therapeutics April 2015, 353 (1) 150-158; DOI: https://doi.org/10.1124/jpet.114.221622
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Discovery of Anti–Claudin-1 Antibodies as Candidate Therapeutics against Hepatitis C Virus
Mayo Yamashita, Manami Iida, Minoru Tada, Yoshitaka Shirasago, Masayoshi Fukasawa, Shotaro Nagase, Akihiro Watari, Akiko Ishii-Watabe, Kiyohito Yagi and Masuo Kondoh

Journal of Pharmacology and Experimental Therapeutics April 2015, 353 (1) 112-118; DOI: https://doi.org/10.1124/jpet.114.217653
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Anti-PCSK9 Antibody Pharmacokinetics and Low-Density Lipoprotein-Cholesterol Pharmacodynamics in Nonhuman Primates Are Antigen Affinity–Dependent and Exhibit Limited Sensitivity to Neonatal Fc Receptor–Binding Enhancement
Kirk R. Henne, Brandon Ason, Monique Howard, Wei Wang, Jeonghoon Sun, Jared Higbee, Jie Tang, Katherine C. Matsuda, Ren Xu, Lei Zhou, Joyce C. Y. Chan, Chadwick King, Derek E. Piper, Randal R. Ketchem, Mark Leo Michaels, Simon M. Jackson and Marc W. Retter

Journal of Pharmacology and Experimental Therapeutics April 2015, 353 (1) 119-131; DOI: https://doi.org/10.1124/jpet.114.221242
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Differential Impact of Amino Acid Substitutions on Critical Residues of the Human Glucagon-Like Peptide-1 Receptor Involved in Peptide Activity and Small-Molecule Allostery
Cassandra Koole, Denise Wootten, John Simms, Laurence J. Miller, Arthur Christopoulos and Patrick M. Sexton

Journal of Pharmacology and Experimental Therapeutics April 2015, 353 (1) 52-63; DOI: https://doi.org/10.1124/jpet.114.220913
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A Selective Orexin-1 Receptor Antagonist Attenuates Stress-Induced Hyperarousal without Hypnotic Effects
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Journal of Pharmacology and Experimental Therapeutics March 2015, 352 (3) 590-601; DOI: https://doi.org/10.1124/jpet.114.220392
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Efficacy and Mechanism of Action of Volasertib, a Potent and Selective Inhibitor of Polo-Like Kinases, in Preclinical Models of Acute Myeloid Leukemia
Dorothea Rudolph, Maria Antonietta Impagnatiello, Claudia Blaukopf, Christoph Sommer, Daniel W. Gerlich, Mareike Roth, Ulrike Tontsch-Grunt, Andreas Wernitznig, Fabio Savarese, Marco H. Hofmann, Christoph Albrecht, Lena Geiselmann, Markus Reschke, Pilar Garin-Chesa, Johannes Zuber, Jürgen Moll, Günther R. Adolf and Norbert Kraut

Journal of Pharmacology and Experimental Therapeutics March 2015, 352 (3) 579-589; DOI: https://doi.org/10.1124/jpet.114.221150
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CHF6001 I: A Novel Highly Potent and Selective Phosphodiesterase 4 Inhibitor with Robust Anti-Inflammatory Activity and Suitable for Topical Pulmonary Administration
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Journal of Pharmacology and Experimental Therapeutics March 2015, 352 (3) 559-567; DOI: https://doi.org/10.1124/jpet.114.220541
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The Apoptotic Mechanism of Action of the Sphingosine Kinase 1 Selective Inhibitor SKI-178 in Human Acute Myeloid Leukemia Cell Lines
Taryn E. Dick, Jeremy A. Hengst, Todd E. Fox, Ashley L. Colledge, Vijay P. Kale, Shen-Shu Sung, Arun Sharma, Shantu Amin, Thomas P. Loughran, Mark Kester, Hong-Gang Wang and Jong K. Yun

Journal of Pharmacology and Experimental Therapeutics March 2015, 352 (3) 494-508; DOI: https://doi.org/10.1124/jpet.114.219659
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A Novel Carboline Derivative Inhibits Nitric Oxide Formation in Macrophages Independent of Effects on Tumor Necrosis Factor α and Interleukin-1β Expression
Ana Cristina G. Grodzki, Bhaskar Poola, Nagarekha Pasupuleti, Michael H. Nantz, Pamela J. Lein and Fredric Gorin

Journal of Pharmacology and Experimental Therapeutics March 2015, 352 (3) 438-447; DOI: https://doi.org/10.1124/jpet.114.220186

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