Research ArticleDrug Discovery and Translational Medicine
Complement Inhibition in Cynomolgus Monkeys by Anti–Factor D Antigen-Binding Fragment for the Treatment of an Advanced Form of Dry Age-Related Macular Degeneration
Kelly M. Loyet, Jeremy Good, Teresa Davancaze, Lizette Sturgeon, Xiangdan Wang, Jihong Yang, Kha N. Le, Maureen Wong, Philip E. Hass, Menno van Lookeren Campagne, Peter C. Haughney, Alyssa Morimoto, Lisa A. Damico-Beyer and Laura E. DeForge
Journal of Pharmacology and Experimental Therapeutics December 2014, 351 (3) 527-537; DOI: https://doi.org/10.1124/jpet.114.215921
Kelly M. Loyet
Departments of Biochemical and Cellular Pharmacology (K.M.L., L.S., L.E.D.), Assay Development and Technologies (J.G., T.D., M.W., A.M.), BioAnalytical Sciences (X.W., J.Y.), Pharmacokinetics and Pharmacodynamics (K.N.L., P.C.H., L.A.D.-B.), Protein Chemistry (P.E.H.), and Immunology (M.v.L.C.), Genentech, South San Francisco, California
Jeremy Good
Departments of Biochemical and Cellular Pharmacology (K.M.L., L.S., L.E.D.), Assay Development and Technologies (J.G., T.D., M.W., A.M.), BioAnalytical Sciences (X.W., J.Y.), Pharmacokinetics and Pharmacodynamics (K.N.L., P.C.H., L.A.D.-B.), Protein Chemistry (P.E.H.), and Immunology (M.v.L.C.), Genentech, South San Francisco, California
Teresa Davancaze
Departments of Biochemical and Cellular Pharmacology (K.M.L., L.S., L.E.D.), Assay Development and Technologies (J.G., T.D., M.W., A.M.), BioAnalytical Sciences (X.W., J.Y.), Pharmacokinetics and Pharmacodynamics (K.N.L., P.C.H., L.A.D.-B.), Protein Chemistry (P.E.H.), and Immunology (M.v.L.C.), Genentech, South San Francisco, California
Lizette Sturgeon
Departments of Biochemical and Cellular Pharmacology (K.M.L., L.S., L.E.D.), Assay Development and Technologies (J.G., T.D., M.W., A.M.), BioAnalytical Sciences (X.W., J.Y.), Pharmacokinetics and Pharmacodynamics (K.N.L., P.C.H., L.A.D.-B.), Protein Chemistry (P.E.H.), and Immunology (M.v.L.C.), Genentech, South San Francisco, California
Xiangdan Wang
Departments of Biochemical and Cellular Pharmacology (K.M.L., L.S., L.E.D.), Assay Development and Technologies (J.G., T.D., M.W., A.M.), BioAnalytical Sciences (X.W., J.Y.), Pharmacokinetics and Pharmacodynamics (K.N.L., P.C.H., L.A.D.-B.), Protein Chemistry (P.E.H.), and Immunology (M.v.L.C.), Genentech, South San Francisco, California
Jihong Yang
Departments of Biochemical and Cellular Pharmacology (K.M.L., L.S., L.E.D.), Assay Development and Technologies (J.G., T.D., M.W., A.M.), BioAnalytical Sciences (X.W., J.Y.), Pharmacokinetics and Pharmacodynamics (K.N.L., P.C.H., L.A.D.-B.), Protein Chemistry (P.E.H.), and Immunology (M.v.L.C.), Genentech, South San Francisco, California
Kha N. Le
Departments of Biochemical and Cellular Pharmacology (K.M.L., L.S., L.E.D.), Assay Development and Technologies (J.G., T.D., M.W., A.M.), BioAnalytical Sciences (X.W., J.Y.), Pharmacokinetics and Pharmacodynamics (K.N.L., P.C.H., L.A.D.-B.), Protein Chemistry (P.E.H.), and Immunology (M.v.L.C.), Genentech, South San Francisco, California
Maureen Wong
Departments of Biochemical and Cellular Pharmacology (K.M.L., L.S., L.E.D.), Assay Development and Technologies (J.G., T.D., M.W., A.M.), BioAnalytical Sciences (X.W., J.Y.), Pharmacokinetics and Pharmacodynamics (K.N.L., P.C.H., L.A.D.-B.), Protein Chemistry (P.E.H.), and Immunology (M.v.L.C.), Genentech, South San Francisco, California
Philip E. Hass
Departments of Biochemical and Cellular Pharmacology (K.M.L., L.S., L.E.D.), Assay Development and Technologies (J.G., T.D., M.W., A.M.), BioAnalytical Sciences (X.W., J.Y.), Pharmacokinetics and Pharmacodynamics (K.N.L., P.C.H., L.A.D.-B.), Protein Chemistry (P.E.H.), and Immunology (M.v.L.C.), Genentech, South San Francisco, California
Menno van Lookeren Campagne
Departments of Biochemical and Cellular Pharmacology (K.M.L., L.S., L.E.D.), Assay Development and Technologies (J.G., T.D., M.W., A.M.), BioAnalytical Sciences (X.W., J.Y.), Pharmacokinetics and Pharmacodynamics (K.N.L., P.C.H., L.A.D.-B.), Protein Chemistry (P.E.H.), and Immunology (M.v.L.C.), Genentech, South San Francisco, California
Peter C. Haughney
Departments of Biochemical and Cellular Pharmacology (K.M.L., L.S., L.E.D.), Assay Development and Technologies (J.G., T.D., M.W., A.M.), BioAnalytical Sciences (X.W., J.Y.), Pharmacokinetics and Pharmacodynamics (K.N.L., P.C.H., L.A.D.-B.), Protein Chemistry (P.E.H.), and Immunology (M.v.L.C.), Genentech, South San Francisco, California
Alyssa Morimoto
Departments of Biochemical and Cellular Pharmacology (K.M.L., L.S., L.E.D.), Assay Development and Technologies (J.G., T.D., M.W., A.M.), BioAnalytical Sciences (X.W., J.Y.), Pharmacokinetics and Pharmacodynamics (K.N.L., P.C.H., L.A.D.-B.), Protein Chemistry (P.E.H.), and Immunology (M.v.L.C.), Genentech, South San Francisco, California
Lisa A. Damico-Beyer
Departments of Biochemical and Cellular Pharmacology (K.M.L., L.S., L.E.D.), Assay Development and Technologies (J.G., T.D., M.W., A.M.), BioAnalytical Sciences (X.W., J.Y.), Pharmacokinetics and Pharmacodynamics (K.N.L., P.C.H., L.A.D.-B.), Protein Chemistry (P.E.H.), and Immunology (M.v.L.C.), Genentech, South San Francisco, California
Laura E. DeForge
Departments of Biochemical and Cellular Pharmacology (K.M.L., L.S., L.E.D.), Assay Development and Technologies (J.G., T.D., M.W., A.M.), BioAnalytical Sciences (X.W., J.Y.), Pharmacokinetics and Pharmacodynamics (K.N.L., P.C.H., L.A.D.-B.), Protein Chemistry (P.E.H.), and Immunology (M.v.L.C.), Genentech, South San Francisco, California
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In this issue
Research ArticleDrug Discovery and Translational Medicine
PD Effects of Anti–Factor D by IVT and Intravenous Dosing in Cynos
Kelly M. Loyet, Jeremy Good, Teresa Davancaze, Lizette Sturgeon, Xiangdan Wang, Jihong Yang, Kha N. Le, Maureen Wong, Philip E. Hass, Menno van Lookeren Campagne, Peter C. Haughney, Alyssa Morimoto, Lisa A. Damico-Beyer and Laura E. DeForge
Journal of Pharmacology and Experimental Therapeutics December 1, 2014, 351 (3) 527-537; DOI: https://doi.org/10.1124/jpet.114.215921
Research ArticleDrug Discovery and Translational Medicine
PD Effects of Anti–Factor D by IVT and Intravenous Dosing in Cynos
Kelly M. Loyet, Jeremy Good, Teresa Davancaze, Lizette Sturgeon, Xiangdan Wang, Jihong Yang, Kha N. Le, Maureen Wong, Philip E. Hass, Menno van Lookeren Campagne, Peter C. Haughney, Alyssa Morimoto, Lisa A. Damico-Beyer and Laura E. DeForge
Journal of Pharmacology and Experimental Therapeutics December 1, 2014, 351 (3) 527-537; DOI: https://doi.org/10.1124/jpet.114.215921
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