Differentiation of mesencephalic progenitor cells into dopaminergic neurons by cytokines

ZD Ling, ED Potter, JW Lipton, PM Carvey - Experimental neurology, 1998 - Elsevier
Rat progenitor cells from the germinal region of the fetal mesencephalon were isolated and
expanded in media containing the mitogen epidermal growth factor. These cells remained …

Tumor necrosis factor α is toxic to embryonic mesencephalic dopamine neurons

SO McGuire, ZD Ling, JW Lipton, CE Sortwell… - Experimental …, 2001 - Elsevier
Levels of the proinflammatory cytokine tumor necrosis factor α (TNFα) are increased in
postmortem brain and cerebral spinal fluid from patients with Parkinson's disease (PD). This …

Striatal trophic factor activity in aging monkeys with unilateral MPTP-induced parkinsonism

TJ Collier, ZD Ling, PM Carvey, A Fletcher-Turner… - Experimental …, 2005 - Elsevier
Striatal trophic activity was assessed in female rhesus monkeys of advancing age rendered
hemiparkinsonian by unilateral intracarotid administration of MPTP. Three age groups were …

GFAP knockout mice have increased levels of GDNF that protect striatal neurons from metabolic and excitotoxic insults

R Hanbury, ZD Ling, J Wuu… - Journal of Comparative …, 2003 - Wiley Online Library
In response to injury and degeneration, astrocytes hypertrophy, extend processes, and
increase production of glial fibrillary acidic protein (GFAP), an intermediate filament protein …

Intravenous immunoglobulin induces interferon-γ and interleukin-6in vivo

ZD Ling, E Yeoh, BT Webb, K Farrell, J Doucette… - Journal of clinical …, 1993 - Springer
Immunoglobulin is known to be an immunomodulator. It can induce protein mediators from
mononuclear cells, particularly monocytesin vitro. Intravenous immunoglobulin (IVIg) has …

Both the antioxidant and D3 agonist actions of pramipexole mediate its neuroprotective actions in mesencephalic cultures

ZD Ling, HC Robie, CW Tong, PM Carvey - Journal of Pharmacology and …, 1999 - ASPET
Pramipexole (PPX) is a full intrinsic activity, direct-acting dopamine (DA) agonist possessing
7-fold higher affinity for D 3 than for D 2 receptors. It also is a potent antioxidant. PPX was …

Striatal trophic activity is reduced in the aged rat brain

ZD Ling, TJ Collier, CE Sortwell, JW Lipton, TQ Vu… - Brain research, 2000 - Elsevier
Our previous studies demonstrated that the survival of a mesencephalic graft was reduced in
aged animals suggesting an age-related decline in target-derived neurotrophic activity. We …

Aggregated immunoglobulin and Fc fragment of IgG induce IL-6 release from human monocytes

ZD Ling, HJ Ziltener, BT Webb, DS Matheson - Cellular immunology, 1990 - Elsevier
The Fc fragment of immunoglobulin (Ig) has been shown to play an important role in the
regulation of humoral immunity, cellular immunity, lymphocyte and monocyte activation, and …

Partial purification of a pramipexole-induced trophic activity directed at dopamine neurons in ventral mesencephalic cultures

ZD Ling, CW Tong, PM Carvey - Brain research, 1998 - Elsevier
We previously demonstrated that media conditioned by exposure to ventral mesencephalic (VM)
cultures in the presence of pramipexole (PPX) and other drugs with dopamine (DA) D 3 …

Dopamine D3 Receptors: Relevance for the Drug Treatment of Parkinson's Disease

B Levant, ZD Ling, PM Carvey - CNS drugs, 1999 - Springer
The discovery of dopamine receptor subtypes provides an opportunity to develop receptor
subtype-specific drugs which could improve the therapeutic index (TI) associated with …