Mechanisms by which autophagy promotes cell survival or death are unclear. We provide
evidence that C 18 -pyridinium ceramide treatment or endogenous C 18 -ceramide generation …

The visual/β-arrestins, a small family of proteins originally described for their role in the
desensitization and intracellular trafficking of G protein–coupled receptors (GPCRs), have …

Mechanisms that alter protein phosphatase 2A (PP2A)‐dependent lung tumour suppression
via the I2PP2A/SET oncoprotein are unknown. We show here that the tumour suppressor …

Background: Spindle positioning during an asymmetric cell division is of fundamental
importance to ensure correct size of daughter cells and segregation of determinants. In the C. …

Arrestins are cytosolic proteins that regulate G-protein-coupled receptor (GPCR) desensitization,
internalization, trafficking and signalling 1 , 2 . Arrestin recruitment uncouples GPCRs …

Chronic cocaine administration reduces G protein signaling efficacy. Here, we report that
the expression of AGS3, which binds to GiαGDP and inhibits GDP dissociation, was …

Understanding the processes of mitochondrial dynamics (fission, fusion, biogenesis, and
mitophagy) has been hampered by the lack of automated, deterministic methods to measure …

During DNA replication, the enzyme telomerase maintains the ends of chromosomes, called
telomeres. Shortened telomeres trigger cell senescence, and cancer cells often have …

Sphingosine kinases (SKs) are promising new therapeutic targets for cancer because they
regulate the balance between pro-apoptotic ceramides and mitogenic sphingosine-1-…

Mitochondrial dysfunction is a common mediator of disease and organ injury. Although
recent studies show that inducing mitochondrial biogenesis (MB) stimulates cell repair and …