Identification of innate IL-5–producing cells and their role in lung eosinophil regulation and antitumor immunity

…, K Tsuneyama, S Yamamoto, Y Hattori… - The Journal of …, 2012 - journals.aai.org
IL-5 is involved in a number of immune responses such as helminth infection and allergy. IL-5
also plays roles in innate immunity by maintaining B-1 B cells and mucosal IgA production. …

Systemic inflammatory response syndrome (SIRS): molecular pathophysiology and gene therapy

N Matsuda, Y Hattori - Journal of pharmacological sciences, 2006 - jstage.jst.go.jp
In recent years, extensive basic science research has led to a clear understanding of the
molecular mechanisms contributing to the pathophysiology of sepsis. Sepsis is now defined as …

Endothelial cellular senescence is inhibited by nitric oxide: implications in atherosclerosis associated with menopause and diabetes

…, QF Ding, S Kamalanathan, Y Hattori… - Proceedings of the …, 2006 - National Acad Sciences
Senescence may contribute to the pathogenesis of atherosclerosis. Although the bioavailability
of nitric oxide (NO) is limited in senescence, the effect of NO on senescence and its …

Diminished function and expression of the cardiac Na+‐Ca2+ exchanger in diabetic rats: implication in Ca2+ overload

Y Hattori, N Matsuda, J Kimura, T Ishitani… - The Journal of …, 2000 - Wiley Online Library
1 The present work was carried out in order to determine whether a decrease in cardiac Na
+ ‐Ca 2+ exchanger (NCX) activity observed in diabetes is caused by a reduction in NCX …

Superoxide dismutase recovers altered endothelium-dependent relaxation in diabetic rat aorta

Y Hattori, H Kawasaki, K Abe… - American Journal of …, 1991 - journals.physiology.org
Experiments were designed to characterize endothelium-dependent relaxation in thoracic
aortic rings obtained from streptozotocin-induced diabetic rats. When the degree of the peak …

Attenuation of endothelium-dependent relaxation in aorta from diabetic rats

Y Oyama, H Kawasaki, Y Hattori, M Kanno - European journal of …, 1986 - Elsevier
Endothelium-dependent relaxation was examined in aortic ring preparations obtained from
rats with streptozotocin-induced diabetes. The endothelium-dependent relaxation which was …

Vascular biology in sepsis: pathophysiological and therapeutic significance of vascular dysfunction

N Matsuda, Y Hattori - Journal of smooth muscle research, 2007 - jstage.jst.go.jp
Sepsis is the leading cause of mortality in critically ill patients. In this pathological syndrome,
septic shock and sequential multiple organ failure correlate with poor outcome. The …

Development of approximate formula for LDL-chol, LDL-apo B and LDL-chol/LDL-apo B as indices of hyperapobetalipoproteinemia and small dense LDL

Y Hattori, M Suzuki, M Tsushima, M Yoshida… - Atherosclerosis, 1998 - Elsevier
Estimation of LDL-chol and LDL-apo B is useful for the diagnosis of hyperapobetalipoproteinemia
(normal LDL-chol with increased LDL-apo B), which is one of the most commonly …

Preferential impairment of nitric oxide–mediated endothelium-dependent relaxation in human cervical arteries after irradiation

T Sugihara, Y Hattori, Y Yamamoto, F Qi, R Ichikawa… - Circulation, 1999 - Am Heart Assoc
Background—Vascular abnormalities are a major cause of postoperative complications in
irradiated tissues. Endothelial cell dysfunction characterized by diminished endothelium-…

Recent advances in the pathophysiology and molecular basis of sepsis-associated organ dysfunction: novel therapeutic implications and challenges

Y Hattori, K Hattori, T Suzuki, N Matsuda - Pharmacology & therapeutics, 2017 - Elsevier
Sepsis is one of the most common reasons for critically ill patients to be admitted to an
intensive care unit and, despite advances in overall medical care, it represents a major clinical …